Pam and Its Ortholog Highwire Interact with and May Negatively Regulate the TSC1·TSC2 Complex (Q28209980)

reason for preferred rank

23 March 2017

Pam and Its Ortholog Highwire Interact with and May Negatively Regulate the TSC1⋅TSC2 Complex (English)

most precise value

0 references

Pam and Its Ortholog Highwire Interact with and May Negatively Regulate the TSC1·TSC2 Complex (English)

1 reference

https://api.crossref.org/works/10.1074/JBC.M310208200

signal transducing adaptor protein

21 March 2024

main subject

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14559897

21 March 2024

Drosophila proteins

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14559897

21 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M310208200

21 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M310208200

21 March 2024

author name string

Vanishree Murthy

1

0 references

Sangyeul Han

2

0 references

Nicole Smith

4

0 references

Naoto Ito

6

0 references

Vijaya Ramesh

7

0 references

Roberta L. Beauchamp

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14559897

21 March 2024

Luciana A. Haddad

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14559897

21 March 2024

language of work or name

English

0 references

publication date

9 January 2004

0 references

14 October 2003

1 reference

full work available at URL

23 March 2017

http://www.jbc.org/article/S0021925818527496/pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14559897

https://api.elsevier.com/content/article/PII:S0021925818527496?httpAccept=text/xml

21 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M310208200

https://api.elsevier.com/content/article/PII:S0021925818527496?httpAccept=text/plain

21 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M310208200

https://syndication.highwire.org/content/doi/10.1074/jbc.M310208200

21 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M310208200

Journal of Biological Chemistry

21 March 2024

published in

1 reference

23 March 2017

volume

279

1 reference

23 March 2017

page(s)

1351-8

0 references

1351-1358

1 reference

23 March 2017

issue

2

1 reference

Identification and characterization of the tuberous sclerosis gene on chromosome 16

23 March 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Akt regulates growth by directly phosphorylating Tsc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Survey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Identification of a large Myc-binding protein that contains RCC1-like repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Regulation of presynaptic terminal organization by C. elegans RPM-1, a putative guanine nucleotide exchanger with a RING-H2 finger domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

rpm-1, a conserved neuronal gene that regulates targeting and synaptogenesis in C. elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Highwire regulates synaptic growth in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Understanding gene and allele function with two-hybrid methods.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Tuberous sclerosis gene 2 product modulates transcription mediated by steroid hormone receptor family members.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

A calmodulin binding site in the tuberous sclerosis 2 gene product is essential for regulation of transcription events and is altered by mutations linked to tuberous sclerosis and lymphangioleiomyomatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Developmental expression of PAM (protein associated with MYC) in the rodent brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Protein associated with Myc (PAM) is a potent inhibitor of adenylyl cyclases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

RING finger proteins: mediators of ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Ubiquitination-dependent mechanisms regulate synaptic growth and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Akt activation promotes degradation of tuberin and FOXO3a via the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

21 January 2018

5

59

1206

Kobayashi

1999

1 reference

https://api.crossref.org/works/10.1074/JBC.M310208200

21 March 2024

18

62

5645

Kenerson

2002

1 reference

https://api.crossref.org/works/10.1074/JBC.M310208200