The human beta-globin locus control region (Q28207378)

The "beta-like-globin" gene domain in human erythroid cells

Europe PubMed Central

title

The human beta-globin locus control region (English)

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author name string

Padraic P Levings

series ordinal

1

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Jörg Bungert

series ordinal

2

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language of work or name

English

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publication date

March 2002

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published in

FEBS Journal

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volume

269

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page(s)

1589-99

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issue

6

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cites work

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Position-independent, high-level expression of the human beta-globin gene in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Looping versus linking: toward a model for long-distance gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Intergenic transcription and developmental remodeling of chromatin subdomains in the human beta-globin locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Developmental regulation of eukaryotic gene loci: which cis-regulatory information is required?

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

The role of EKLF in human beta-globin gene competition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Krüppel-like factors: three fingers in many pies

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

FKLF, a novel Krüppel-like factor that activates human embryonic and fetal beta-like globin genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Role of NF-Y in in vivo regulation of the gamma-globin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

The effect of distance on long-range chromatin interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Role of gene order in developmental control of human gamma- and beta-globin gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Effects of altered gene order or orientation of the locus control region on human beta-globin gene expression in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Looping, linking, and chromatin activity: new insights into beta-globin locus regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Developmental regulation of beta-globin gene switching.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Locus control regions of mammalian beta-globin gene clusters: combining phylogenetic analyses and experimental results to gain functional insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

The locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Histone methylation versus histone acetylation: new insights into epigenetic regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Transcription complex stability and chromatin dynamics in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Sequences flanking hypersensitive sites of the beta-globin locus control region are required for synergistic enhancement

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

The world according to Maf

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Erythroid Kruppel-like factor is recruited to the CACCC box in the beta-globin promoter but not to the CACCC box in the gamma-globin promoter: the role of the neighboring promoter elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Multilineage gene expression precedes commitment in the hemopoietic system

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Activation of the beta-globin locus control region precedes commitment to the erythroid lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Conserved E boxes function as part of the enhancer in hypersensitive site 2 of the beta-globin locus control region. Role of basic helix-loop-helix proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Self-association of the erythroid transcription factor GATA-1 mediated by its zinc finger domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 and EKLF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Long-distance control of origin choice and replication timing in the human beta-globin locus are independent of the locus control region

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Steroid hormone receptors: many actors in search of a plot

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Transcription of the hypersensitive site HS2 enhancer in erythroid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Transcription of the HS2 enhancer toward a cis-linked gene is independent of the orientation, position, and distance of the enhancer relative to the gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Intergenic transcription and transinduction of the human beta-globin locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Intergenic transcription in the human beta-globin gene cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Insulators and boundaries: versatile regulatory elements in the eukaryotic genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

The protein CTCF is required for the enhancer blocking activity of vertebrate insulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Positions of potential: nuclear organization and gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

A functional enhancer suppresses silencing of a transgene and prevents its localization close to centrometric heterochromatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Turning telomeres off and on.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Activation of the beta globin locus by transcription factors and chromatin modifiers

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Reconstitution of human beta-globin locus control region hypersensitive sites in the absence of chromatin assembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

RNA polymerase II elongation through chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Developmentally dynamic histone acetylation pattern of a tissue-specific chromatin domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Visualization and analysis of unfolded nucleosomes associated with transcribing chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Histone acetylation is required to maintain the unfolded nucleosome structure associated with transcribing DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Activation of beta-major globin gene transcription is associated with recruitment of NF-E2 to the beta-globin LCR and gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X

Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2002.02797.X