New targets for inhibitors of HIV-1 replication (Q28202551)

Nature Reviews Molecular Cell Biology

Europe PubMed Central

title

New targets for inhibitors of HIV-1 replication (English)

0 references

author name string

J P Moore

series ordinal

1

0 references

M Stevenson

series ordinal

2

0 references

language of work or name

English

0 references

publication date

October 2000

0 references

published in

0 references

volume

1

0 references

issue

1

0 references

page(s)

40-9

0 references

cites work

Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators

1 reference

7 January 2021

Highly active antiretroviral therapy in a large urban clinic: risk factors for virologic failure and adverse drug reactions

1 reference

7 January 2021

Transmission of antiretroviral-drug-resistant HIV-1 variants

1 reference

7 January 2021

Persistence of HIV-1 Transcription in Peripheral-Blood Mononuclear Cells in Patients Receiving Potent Antiretroviral Therapy

1 reference

7 January 2021

Selective interactions of polyanions with basic surfaces on human immunodeficiency virus type 1 gp120

1 reference

7 January 2021

Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses

1 reference

7 January 2021

Increased infectivity of HIV type 1 particles bound to cell surface and solid-phase ICAM-1 and VCAM-1 through acquired adhesion molecules LFA-1 and VLA-4.

1 reference

7 January 2021

SPC3, a V3 loop-derived synthetic peptide inhibitor of HIV-1 infection, binds to cell surface glycosphingolipids

1 reference

7 January 2021

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

1 reference

7 January 2021

The bis-azo compound FP-21399 inhibits HIV-1 replication by preventing viral entry

1 reference

7 January 2021

Resistance of the human immunodeficiency virus to the inhibitory action of negatively charged albumins on virus binding to CD4

1 reference

7 January 2021

Single-dose safety, pharmacology, and antiviral activity of the human immunodeficiency virus (HIV) type 1 entry inhibitor PRO 542 in HIV-infected adults

1 reference

7 January 2021

Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic

1 reference

7 January 2021

Rational engineering of a miniprotein that reproduces the core of the CD4 site interacting with HIV-1 envelope glycoprotein

1 reference

7 January 2021

A humanized form of a CD4-specific monoclonal antibody exhibits decreased antigenicity and prolonged plasma half-life in rhesus monkeys while retaining its unique biological and antiviral properties

1 reference

7 January 2021

Will multiple coreceptors need to be targeted by inhibitors of human immunodeficiency virus type 1 entry?

1 reference

7 January 2021

Preferential coreceptor utilization and cytopathicity by dual-tropic HIV-1 in human lymphoid tissue ex vivo.

1 reference

7 January 2021

A new classification for HIV-1

1 reference

7 January 2021

Identifying the target cell in primary simian immunodeficiency virus (SIV) infection: highly activated memory CD4(+) T cells are rapidly eliminated in early SIV infection in vivo

1 reference

7 January 2021

In vivo HIV-1 infection of CD45RA(+)CD4(+) T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4(+) T cell decline

1 reference

7 January 2021

Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

1 reference

7 January 2021

CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro

1 reference

7 January 2021

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1 reference

7 January 2021

Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry

1 reference

7 January 2021

Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells

1 reference

7 January 2021

The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

1 reference

7 January 2021

The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1

1 reference

7 January 2021

Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist.

1 reference

7 January 2021

Dissociation of the signalling and antiviral properties of SDF-1-derived small peptides

1 reference

7 January 2021

HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication

1 reference

7 January 2021

Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity

1 reference

7 January 2021

Genetic subtype-independent inhibition of human immunodeficiency virus type 1 replication by CC and CXC chemokines.

1 reference

7 January 2021

CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4(+) T cells: role of signal transduction

1 reference

7 January 2021

The CC-chemokine RANTES increases the attachment of human immunodeficiency virus type 1 to target cells via glycosaminoglycans and also activates a signal transduction pathway that enhances viral infectivity

1 reference

7 January 2021

CD4-independent infection by HIV-2 is mediated by fusin/CXCR4.

1 reference

7 January 2021

Differential inhibition of human immunodeficiency virus type 1 fusion, gp120 binding, and CC-chemokine activity by monoclonal antibodies to CCR5

1 reference

7 January 2021

Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4

1 reference

7 January 2021

A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection

1 reference

7 January 2021

A small-molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor

1 reference

7 January 2021

AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.

1 reference

7 January 2021

T134, a small-molecule CXCR4 inhibitor, has no cross-drug resistance with AMD3100, a CXCR4 antagonist with a different structure.

1 reference

7 January 2021

A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

1 reference

7 January 2021

Inhibition of in vitro and in vivo HIV replication by a distamycin analogue that interferes with chemokine receptor function: a candidate for chemotherapeutic and microbicidal application

1 reference

7 January 2021

A synthetic peptide inhibitor of human immunodeficiency virus replication: correlation between solution structure and viral inhibition

1 reference

7 January 2021

HIV-1 inhibition by a peptide

1 reference

7 January 2021

Conformational changes in cell surface HIV-1 envelope glycoproteins are triggered by cooperation between cell surface CD4 and co-receptors

1 reference

7 January 2021

Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry

1 reference

7 January 2021

Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements

1 reference

7 January 2021

Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket

1 reference

7 January 2021

Sensitivity to a nonpeptidic compound (RPR103611) blocking human immunodeficiency virus type 1 Env-mediated fusion depends on sequence and accessibility of the gp41 loop region

1 reference

7 January 2021

The site of an immune-selected point mutation in the transmembrane protein of human immunodeficiency virus type 1 does not constitute the neutralization epitope

1 reference

7 January 2021

A synthetic all D-amino acid peptide corresponding to the N-terminal sequence of HIV-1 gp41 recognizes the wild-type fusion peptide in the membrane and inhibits HIV-1 envelope glycoprotein-mediated cell fusion

1 reference

7 January 2021

Determinants of human immunodeficiency virus type 1 resistance to gp41-derived inhibitory peptides.

1 reference

7 January 2021

The molecular target of bicyclams, potent inhibitors of human immunodeficiency virus replication

1 reference

7 January 2021

T-cell-line-tropic human immunodeficiency virus type 1 that is made resistant to stromal cell-derived factor 1alpha contains mutations in the envelope gp120 but does not show a switch in coreceptor use

1 reference

7 January 2021

Involvement of both the V2 and V3 regions of the CCR5-tropic human immunodeficiency virus type 1 envelope in reduced sensitivity to macrophage inflammatory protein 1alpha

1 reference

7 January 2021

Specific incorporation of cyclophilin A into HIV-1 virions

1 reference

7 January 2021

Functional association of cyclophilin A with HIV-1 virions

1 reference

7 January 2021

Antiretroviral therapy: 'the state of the art'.

1 reference

7 January 2021

First glimpses at structure-function relationships of the nucleocapsid protein of retroviruses

1 reference

7 January 2021

The in vitro ejection of zinc from human immunodeficiency virus (HIV) type 1 nucleocapsid protein by disulfide benzamides with cellular anti-HIV activity

1 reference

7 January 2021

Inhibitors of HIV nucleocapsid protein zinc fingers as candidates for the treatment of AIDS.

1 reference

7 January 2021

Synthesis and biological properties of novel pyridinioalkanoyl thiolesters (PATE) as anti-HIV-1 agents that target the viral nucleocapsid protein zinc fingers.

1 reference

7 January 2021

Role of the N-terminal zinc finger of human immunodeficiency virus type 1 nucleocapsid protein in virus structure and replication

1 reference

7 January 2021

Multiple effects of an anti-human immunodeficiency virus nucleocapsid inhibitor on virus morphology and replication.

1 reference

7 January 2021

HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure

1 reference

7 January 2021

Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells

1 reference

7 January 2021

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1 reference

7 January 2021

HIV-1 genome nuclear import is mediated by a central DNA flap

1 reference

7 January 2021

HIV-1 reverse transcription. A termination step at the center of the genome

1 reference

7 January 2021

Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection

1 reference

7 January 2021

Retroviral cDNA integration: mechanism, applications and inhibition

1 reference

7 January 2021

Human immunodeficiency virus type 1 integrase: effects of mutations on viral ability to integrate, direct viral gene expression from unintegrated viral DNA templates, and sustain viral propagation in primary cells

1 reference

7 January 2021

Salicylhydrazine-containing inhibitors of HIV-1 integrase: implication for a selective chelation in the integrase active site

1 reference

7 January 2021

Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells

1 reference

7 January 2021

HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway

1 reference

7 January 2021

Nuclear localization of human immunodeficiency virus type 1 integrase expressed as a fusion protein with green fluorescent protein.

1 reference

7 January 2021

HIV nuclear import: What's the flap?

1 reference

7 January 2021

Probing contacts between the ribonuclease H domain of HIV-1 reverse transcriptase and nucleic acid by site-specific photocross-linking.

1 reference

7 January 2021

Evidence for a newly discovered cellular anti-HIV-1 phenotype

1 reference

7 January 2021

Inhibitory mechanism of the CXCR4 antagonist T22 against human immunodeficiency virus type 1 infection.

1 reference

7 January 2021

A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

1 reference

7 January 2021

Inhibition of G-protein-coupled receptor function by disruption of transmembrane domain interactions.

1 reference

7 January 2021

Atomic structure of the ectodomain from HIV-1 gp41

1 reference

7 January 2021

Core structure of gp41 from the HIV envelope glycoprotein

1 reference

7 January 2021

Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41

1 reference

7 January 2021

Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry

1 reference

7 January 2021