Degradation of B-Myb by ubiquitin-mediated proteolysis: involvement of the Cdc34-SCF(p45Skp2) pathway (Q28139370)

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V Brondani

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K H Klempnauer

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S Ferrari

Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb

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publication date

15 June 2000

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language of work or name

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19

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issue

26

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page(s)

2986-95

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cites work

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Oncogenic activation of c-Myb by carboxyl-terminal truncation leads to decreased proteolysis by the ubiquitin-26S proteasome pathway

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Molecular cloning, expression and in vitro functional characterization of Myb-related proteins in Xenopus

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Regulation of E2F through ubiquitin-proteasome-dependent degradation: stabilization by the pRB tumor suppressor protein

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A common human skin tumour is caused by activating mutations in beta-catenin

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Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway

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Protein truncation is required for the activation of the c-myb proto-oncogene

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Myb: a transcriptional activator linking proliferation and differentiation in hematopoietic cells.

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Skipping into the E2F1-destruction pathway.

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Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability

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Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins

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Translational control of p27Kip1 accumulation during the cell cycle

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Roles of ubiquitin-mediated proteolysis in cell cycle control

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The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway

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Regulation of B-Myb activity by cyclin D1

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An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin

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How the cyclin became a cyclin: regulated proteolysis in the cell cycle

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B-Myb function can be markedly enhanced by cyclin A-dependent kinase and protein truncation

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Substrate targeting in the ubiquitin system

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Constitutive expression of B-myb can bypass p53-induced Waf1/Cip1-mediated G1 arrest

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Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway

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Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

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Cyclin-dependent kinases: engines, clocks, and microprocessors

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Isolation of human cDNA clones of myb-related genes, A-myb and B-myb

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Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

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PEST sequences and regulation by proteolysis

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Regulation of BALB/c 3T3 fibroblast proliferation by B-myb is accompanied by selective activation of cdc2 and cyclin D1 expression

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The retinoblastoma family member p107 binds to B-MYB and suppresses its autoregulatory activity

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Activation of human B-MYB by cyclins

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Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc.

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The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties

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B-myb is required for inner cell mass formation at an early stage of development

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Truncated c-Myb expression in the human leukemia cell line TK-6

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Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain

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Transcription regulation by murine B-myb is distinct from that by c-myb.

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p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

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Phosphorylation and activation of B-Myb by cyclin A-Cdk2.

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Linking Myb to the cell cycle: cyclin-dependent phosphorylation and regulation of A-Myb activity

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Cell cycle regulation of E2F site occupation in vivo.

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B-Myb, a repressed trans-activating protein

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