Identification of Grb10 as a direct substrate for members of the Src tyrosine kinase family (Q28139366)

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L Q Dong

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D Hu

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F Liu

The SH2-containing adapter protein GRB10 interacts with BCR-ABL

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language of work or name

English

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publication date

8 June 2000

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published in

Oncogene

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volume

19

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issue

25

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page(s)

2895-903

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cites work

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Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location

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p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells

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Inhibition of hGrb10 binding to the insulin receptor by functional domain-mediated oligomerization

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Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain

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Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains

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Requirement of phosphatidylinositol-3 kinase modification for its association with p60src

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Cooperation of Src homology domains in the regulated binding of phosphatidylinositol 3-kinase. A role for the Src homology 2 domain

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Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus

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Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology [...]

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The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease

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The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts

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Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function

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Binding of SH2 containing proteins to the insulin receptor: a new way for modulating insulin signalling.

21 January 2018

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The v-Src SH3 domain binds phosphatidylinositol 3'-kinase

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Grb10/GrbIR as an in vivo substrate of Tec tyrosine kinase

21 January 2018

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Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases

21 January 2018

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mGrb10 interacts with Nedd4

21 January 2018

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Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases

21 January 2018

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Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling

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The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10

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Src phosphorylates the insulin-like growth factor type I receptor on the autophosphorylation sites. Requirement for transformation by src.

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Sequence specificity of C-terminal Src kinase (CSK)--a comparison with Src-related kinases c-Fgr and Lyn.

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The function of GRB2 in linking the insulin receptor to Ras signaling pathways

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Recognition and specificity in protein tyrosine kinase-mediated signalling

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Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells

21 January 2018

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The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation

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The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells

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Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis

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Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains

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The IRS-signalling system: a network of docking proteins that mediate insulin action

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Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok

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Efficient transformation of mammalian cells with constructs containing a puromycin-resistance marker

21 January 2018

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Regulation, substrates and functions of src

21 January 2018

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7 January 2021

Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma

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7 January 2021

Site-directed mutagenesis and yeast two-hybrid studies of the insulin and insulin-like growth factor-1 receptors: the Src homology-2 domain-containing protein hGrb10 binds to the autophosphorylated tyrosine residues in the kinase domain of the insul

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7 January 2021

Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate

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7 January 2021