The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity (Q28139188)

Europe PubMed Central

title

The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity (English)

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author name string

R M Siegel

1

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F K Chan

2

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H J Chun

3

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M J Lenardo

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor

4

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language of work or name

English

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publication date

December 2000

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published in

Nature Immunology

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volume

1

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page(s)

469-74

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issue

6

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cites work

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

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The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

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Modularity in the TNF-receptor family

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A novel domain within the 55 kd TNF receptor signals cell death

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Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation

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Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family

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Expression of the functional soluble form of human fas ligand in activated lymphocytes.

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LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing

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Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95

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7 January 2021

A death-domain-containing receptor that mediates apoptosis

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7 January 2021

Characterization of two receptors for TRAIL

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7 January 2021

TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB

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7 January 2021

FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis

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7 January 2021

An antagonist decoy receptor and a death domain-containing receptor for TRAIL

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7 January 2021

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.

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7 January 2021

Identification and functional characterization of DR6, a novel death domain-containing TNF receptor

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7 January 2021

Identification of a ligand for the death-domain-containing receptor Apo3

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7 January 2021

Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer

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7 January 2021

Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors

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7 January 2021

Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family

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7 January 2021

A novel receptor for Apo2L/TRAIL contains a truncated death domain

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7 January 2021

Anti-TNF alpha therapy is useful in rheumatoid arthritis and Crohn's disease: analysis of the mechanism of action predicts utility in other diseases

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7 January 2021

A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

1 reference

7 January 2021

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

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7 January 2021

NMR structure and mutagenesis of the FADD (Mort1) death-effector domain

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7 January 2021

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

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7 January 2021

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

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7 January 2021

Caspases: killer proteases

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7 January 2021

Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia.

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7 January 2021

Autoproteolytic activation of pro-caspases by oligomerization.

1 reference

7 January 2021

An induced proximity model for caspase-8 activation.

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7 January 2021

Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal

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7 January 2021

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

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7 January 2021

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

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7 January 2021

Two CD95 (APO-1/Fas) signaling pathways

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7 January 2021

Autocrine feedback death and the regulation of mature T lymphocyte antigen responses.

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7 January 2021

Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment

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7 January 2021

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation.

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7 January 2021

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

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7 January 2021

Induction of apoptosis in mature T cells by tumour necrosis factor

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7 January 2021

Resistance of cultured peripheral T cells towards activation-induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death-inducing signaling complex

1 reference

7 January 2021

Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis.

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7 January 2021

The role of c-FLIP in modulation of CD95-induced apoptosis

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7 January 2021

Receptor-stimulated death pathway is opened by antigen in mature T cells

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7 January 2021

Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis

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7 January 2021

T cell receptor signals enhance susceptibility to Fas-mediated apoptosis

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7 January 2021

Qualitative and quantitative contributions of the T cell receptor zeta chain to mature T cell apoptosis

1 reference

7 January 2021

Selective induction of apoptosis in mature T lymphocytes by variant T cell receptor ligands.

1 reference

7 January 2021

Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis

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7 January 2021

Differential ability of T cell subsets to undergo activation-induced cell death

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7 January 2021

Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle.

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7 January 2021

Dichotomy between naïve and memory CD4(+) T cell responses to Fas engagement

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7 January 2021

The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens

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7 January 2021

Self-tolerance checkpoints in B lymphocyte development

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7 January 2021

Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor.

1 reference

7 January 2021

Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells.

1 reference

7 January 2021

TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease

1 reference

7 January 2021

Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS

1 reference

7 January 2021

Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI

1 reference

7 January 2021

TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation

1 reference

7 January 2021

BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population

1 reference

7 January 2021

Differential induction of apoptosis by Fas-Fas ligand interactions in human monocytes and macrophages

1 reference

7 January 2021

FLICE-inhibitory protein expression during macrophage differentiation confers resistance to fas-mediated apoptosis

1 reference

7 January 2021

CD40 ligand inhibits Fas/CD95-mediated apoptosis of human blood-derived dendritic cells.

1 reference

7 January 2021

In vivo detection of dendritic cell antigen presentation to CD4(+) T cells.

1 reference

7 January 2021

Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II

1 reference

7 January 2021

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

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7 January 2021

A role for CD95 ligand in preventing graft rejection

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7 January 2021

Not so Fas: Re-evaluating the mechanisms of immune privilege and tumor escape

1 reference

7 January 2021

Fas and Fas Ligand Expressed on Cells of the Immune System, not on the Target Tissue, Control Induction of Experimental Autoimmune Uveitis

1 reference

7 January 2021

Regulation of the proinflammatory effects of Fas ligand (CD95L).

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7 January 2021

Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction

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7 January 2021

Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts.

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7 January 2021

Fas transduces activation signals in normal human T lymphocytes

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7 January 2021

Caspase activation is required for T cell proliferation

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7 January 2021

Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells

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7 January 2021

The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

1 reference

7 January 2021

The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn

1 reference

7 January 2021

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1 reference

7 January 2021

The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster

1 reference

7 January 2021

Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1 reference

7 January 2021

Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity

1 reference

7 January 2021

An inherited disorder of lymphocyte apoptosis: the autoimmune lymphoproliferative syndrome

1 reference

7 January 2021

A novel lymphoproliferative/autoimmune syndrome resembling murine lpr/gld disease

1 reference

7 January 2021

Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease

1 reference

7 January 2021

Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Faslpr mice

1 reference

7 January 2021

Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice

1 reference

7 January 2021

Inhibition of autoimmune diabetes by Fas ligand: the paradox is solved

1 reference

7 January 2021

Significant role for Fas in the pathogenesis of autoimmune diabetes.

1 reference

7 January 2021

Fas has a crucial role in the progression of experimental autoimmune encephalomyelitis.

1 reference

7 January 2021

Dual role for Fas ligand in the initiation of and recovery from experimental allergic encephalomyelitis

1 reference

7 January 2021

Fas-mediated apoptosis in clinical remissions of relapsing experimental autoimmune encephalomyelitis

1 reference

7 January 2021

T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis

1 reference

7 January 2021

Autoimmune lymphoproliferative syndrome with defective Fas: genotype influences penetrance

1 reference

7 January 2021

The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo-1) mutations

1 reference

7 January 2021

Crystallographic analysis of CD40 recognition and signaling by human TRAF2

1 reference

7 January 2021

Death receptors: signaling and modulation

1 reference

7 January 2021

Tumor necrosis factor receptor and Fas signaling mechanisms.

1 reference

7 January 2021

A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling

1 reference

7 January 2021

Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations

1 reference

7 January 2021

Identification and characterization of a ligand-independent oligomerization domain in the extracellular region of the CD95 death receptor

1 reference

7 January 2021