Metabolism of some "second"- and "fourth"-generation antidepressants: iprindole, viloxazine, bupropion, mianserin, maprotiline, trazodone, nefazodone, and venlafaxine (Q28137902)

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scientific article (publication date: August 1999)

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English	Metabolism of some "second"- and "fourth"-generation antidepressants: iprindole, viloxazine, bupropion, mianserin, maprotiline, trazodone, nefazodone, and venlafaxine	scientific article (publication date: August 1999)

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Metabolism of some "second"- and "fourth"-generation antidepressants: iprindole, viloxazine, bupropion, mianserin, maprotiline, trazodone, nefazodone, and venlafaxine (English)

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author name string

S Rotzinger

1

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M Bourin

2

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Y Akimoto

3

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R T Coutts

4

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G B Baker

5

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language of work or name

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publication date

August 1999

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Cellular and Molecular Neurobiology

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19

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4

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427-42

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Pharmacology and neurochemistry of nefazodone, a novel antidepressant drug

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Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine

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Detection and quantitation of a ring-hydroxylated metabolite of the antidepressant drug tranylcypromine

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The disposition of [14C]iprindole in man, dog, miniature swine, rhesus monkey and rat

1 reference

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Maprotiline metabolism appears to co-segregate with the genetically-determined CYP2D6 polymorphic hydroxylation of debrisoquine

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Drug interactions with newer antidepressants: role of human cytochromes P450

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Effects of trazodone and fluoxetine in the treatment of major depression: therapeutic pharmacokinetic and pharmacodynamic interactions through formation of meta-chlorophenylpiperazine.

1 reference

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Antidepressant drug selection: criteria and options.

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Adverse interactions encountered when using trazodone to treat insomnia associated with fluoxetine

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The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyltransferases in man using sparteine, caffeine, and paracetamol as probes

1 reference

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Elevated antidepressant plasma levels after addition of fluoxetine

1 reference

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Bupropion in depression. II. The role of metabolites in clinical outcome

1 reference

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Antidepressant options: venlafaxine in perspective

1 reference

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Basic metabolites of trazodone in humans

1 reference

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The pharmacokinetics of venlafaxine when given in a twice-daily regimen.

1 reference

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Cytochrome P450 enzymes: interpretation of their interactions with selective serotonin reuptake inhibitors. Part I.

1 reference

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Possible trazodone potentiation of fluoxetine: a case series

1 reference

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Steady-state plasma concentrations of mianserin and its major active metabolite, desmethylmianserin.

1 reference

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Pharmacokinetics of bupropion and metabolites in plasma and brain of rats, mice, and guinea pigs

1 reference

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Serotonin syndrome produced by paroxetine and low-dose trazodone

1 reference

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Clinical pharmacokinetics of bupropion: a review

1 reference

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Venlafaxine: a heterocyclic antidepressant.

1 reference

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Pharmacokinetics, absolute bioavailability, and disposition of [14C]nefazodone in humans

1 reference

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Lack of interaction between nefazodone and cimetidine: a steady state pharmacokinetic study in humans

1 reference

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Trazodone. A review of its pharmacology, therapeutic use in depression and therapeutic potential in other disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

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Trazodone is metabolized to m-chlorophenylpiperazine by CYP3A4 from human sources

1 reference

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Quantitative high-performance liquid chromatographic assay for the determination of maprotiline and oxaprotiline in human plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

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Stereoselective disposition of mianserin is related to debrisoquin hydroxylation polymorphism

1 reference

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12 December 2020

based on heuristic

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Coadministration of nefazodone and benzodiazepines: IV. A pharmacokinetic interaction study with lorazepam

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

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Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers

1 reference

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Pharmacokinetic interaction between multiple-dose venlafaxine and single-dose lithium

1 reference

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Nefazodone: a new antidepressant

1 reference

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Assessment of pharmacokinetic and pharmacodynamic drug interactions between nefazodone and digoxin in healthy male volunteers

1 reference

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Nefazodone-induced carbamazepine toxicity

1 reference

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12 December 2020

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Bupropion plasma levels and CYP2D6 phenotype

1 reference

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based on heuristic

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A gas chromatographic procedure for separation and quantitation of the enantiomers of the antidepressant tranylcypromine

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

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Pharmacokinetic and pharmacodynamic evaluation of warfarin and nefazodone coadministration in healthy subjects

1 reference

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Estimation of maprotiline in serum by gas-chromatography, with use of a nitrogen-specific detector

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

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based on heuristic

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Recent studies on the MAO inhibitor phenelzine and its possible metabolites.

1 reference

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Determination of the antidepressants maprotiline and amoxapine, and their metabolites, in plasma by liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

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Pharmacokinetic drug interaction potential of selective serotonin reuptake inhibitors.

1 reference

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Iprindole-amphetamine interactions in the rat: the role of aromatic hydroxylation of amphetamine in its mode of action

1 reference

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Single dose pharmacokinetics of trazodone in healthy subjects

1 reference

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The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of m-chlorophenylpiperazine

1 reference

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The disposition and metabolism of I.C.I. 58,834 (viloxazine) in animals

1 reference

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based on heuristic

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The disposition of bupropion and its metabolites in healthy male volunteers after single and multiple doses

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

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based on heuristic

inferred from PubMed ID database lookup

Elevation of plasma phenytoin by viloxazine in epileptic patients: a clinically significant drug interaction

1 reference

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based on heuristic

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Introduction of a composite parameter to the pharmacokinetics of venlafaxine and its active O-desmethyl metabolite

1 reference

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based on heuristic

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Carbamazepine and cigarette smoking induce differentially the metabolism of codeine in man

1 reference

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12 December 2020

based on heuristic

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Safety, tolerance, and preliminary pharmacokinetics of nefazodone after administration of single and multiple oral doses to healthy adult male volunteers: a double-blind, phase I study

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of carbamazepine coadministration on plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of mianserin and its metabolites by human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxcarbazepine: pharmacokinetic interactions and their clinical relevance

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydroxylation of phenylethylamine by rat liver preparations. Inhibition studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma concentrations of trazodone and 1-(3-chlorophenyl)piperazine in man after a single oral dose of trazodone

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nefazodone pharmacokinetics: assessment of nonlinearity, intra-subject variability and time to attain steady-state plasma concentrations after dose escalation and de-escalation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carbamazepine but not valproate induces bupropion metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Disposition and Metabolism of I.C.I. 58,834 (Viloxazine) in Humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mianserin: a review of its pharmacological properties and therapeutic efficacy in depressive illness

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo and in vitro stereoselective metabolism of mianserin in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of bupropion and its metabolites in cigarette smokers versus nonsmokers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions of iprindole with fenfluramine metabolism in rat brain and liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single and multiple dose pharmacokinetics of nefazodone in subjects classified as extensive and poor metabolizers of dextromethorphan

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enantiomeric aspects of the metabolism of mianserin in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of trazodone during multiple dosing to psychiatric patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonlinear pharmacokinetics of nefazodone after escalating single and multiple oral doses

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of desipramine and iprindole on levels of enantiomers of fluoxetine in rat brain and urine

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic analysis of maprotiline and its demethylated metabolite in serum and brain of rats after acute and chronic oral administration of maprotiline

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human CYP2D6 and metabolism of m-chlorophenylpiperazine

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluoxetine drug-drug interactions: I. Antidepressants and antipsychotics

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of phenytoin, carbamazepine, and valproic acid on caffeine metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological significance of the species differences in bupropion metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

m-Chlorophenylpiperazine as a probe of serotonin function

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enantioselective determination of mianserin and its desmethyl metabolite in plasma during treatment of depressed Japanese patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of the enantiomers of mianserin, desmethylmianserin, and 8-hydroxymianserin in the plasma and urine of mianserin-treated patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coadministration of nefazodone and benzodiazepines: I. Pharmacodynamic assessment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liquid chromatographic separation of antidepressant drugs: II. Amoxapine and maprotiline

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of iprindole on the metabolism of trimipramine in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and identification of the major urinary metabolite of m-chlorophenylpiperazine in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of various factors on steady state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological aspects of mianserin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT-2 and 5-HT-1c) receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic optimisation of therapy with newer antidepressants

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carbamazepine-viloxazine interaction in patients with epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

l-(m-Chlorophenyl)piperazine: a metabolite of trazodone isolated from rat urine

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism and kinetics of bupropion

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluoxetine drug-drug interactions. II.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of trazodone metabolism by thioridazine in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible serotonin syndrome with trazodone addition to fluoxetine

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of hepatic P-450 isoenzymes by serotonin selective reuptake inhibitors: in vitro and in vivo findings and their implications for patient care

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic interactions between theophylline and other medication (Part I).

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacokinetics and pharmacological effects of carbamazepine and carbamazepine-10,11-epoxide. An update

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(—)-m-Chlorophenyl-piperazine, a central 5-hydroxytryptamine agonist, is a metabolite of trazodone

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Investigation of pharmacokinetic and pharmacodynamic interactions after coadministration of nefazodone and haloperidol

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coadministration of nefazodone and benzodiazepines: III. A pharmacokinetic interaction study with alprazolam

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of maprotiline and desmethylmaprotiline in plasma and urine by gas chromatography with nitrogen-phosphorus detection

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A study of the effect of age and gender on the pharmacokinetics of nefazodone after single and multiple doses

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coadministration of nefazodone and benzodiazepines: II. A pharmacokinetic interaction study with triazolam

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacologic profile and efficacy of venlafaxine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The safety profile of nefazodone

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delirium associated with bupropion

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Venlafaxine oxidation in vitro is catalysed by CYP2D6.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of hepatic impairment on the pharmacokinetics of nefazodone and two of its metabolites after single and multiple oral doses

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacogenetics of the selective serotonin reuptake inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the metabolites of the antidepressant drug nefazodone in human urine and plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug-drug interactions involving antidepressants: focus on venlafaxine

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antidepressants, metabolites, and apparent drug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The potential therapeutic role of the enantiomers and metabolites of mianserin

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural characterization of the urinary metabolites of iprindole in rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on metabolism of trazodone. I. Metabolic fate of (14C)trazodone hydrochloride in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluoxetine impairs clearance of alprazolam but not of clonazepam

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450 enzymes: interpretation of their interactions with selective serotonin reuptake inhibitors. Part II.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10379419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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