Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity (Q28116068)

GOA release 2020-03-11

author name string

Lawrence S. Argetsinger

1

1 reference

4 January 2017

Jean-Louis K. Kouadio

2

1 reference

4 January 2017

Hanno Steen

3

1 reference

4 January 2017

Allan Stensballe

4

1 reference

4 January 2017

Ole N. Jensen

5

1 reference

4 January 2017

Christin Carter-Su

Molecular and Cellular Biology

6

1 reference

4 January 2017

language of work or name

English

0 references

publication date

1 June 2004

1 reference

4 January 2017

1 reference

4 January 2017

24

1 reference

4 January 2017

4955–4967

1 reference

4 January 2017

11

1 reference

4 January 2017

APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl

1 reference

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TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B

20 March 2017

1 reference

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1 reference

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The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416404

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1 reference

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Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416404

Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416404

Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416404

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1 reference

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Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain

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1 reference

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1 reference

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Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

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1 reference

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1 reference

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The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor

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1 reference

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1 reference

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CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling

20 March 2017

1 reference

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Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416404

Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416404

Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416404

Induction of 15-lipoxygenase expression by IL-13 requires tyrosine phosphorylation of Jak2 and Tyk2 in human monocytes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416404

Jak2 is essential for signaling through a variety of cytokine receptors

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416404

Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416404

The conserved box 1 motif of cytokine receptors is required for association with JAK kinases

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416404

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416404

The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416404

Regions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptor

20 March 2017

1 reference

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Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta

20 March 2017

1 reference

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1 reference

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Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

20 March 2017

1 reference

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Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling

20 March 2017

1 reference

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Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors

29 September 2017

1 reference

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YXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling

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1 reference

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Regulation of erythropoietin-induced STAT serine phosphorylation by distinct mitogen-activated protein kinases

29 September 2017

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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