Novel contraceptive targets to inhibit ovulation: the prostaglandin E2 pathway (Q28083349)

main subject

reproductive medicine

0 references

1 reference

Diane M. Duffy

1

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language of work or name

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2015

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Human Reproduction Update

published in

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volume

21

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page(s)

652-70

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issue

5

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Multiple drug resistance-associated protein 4 (MRP4), prostaglandin transporter (PGT), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE2 levels in cancer

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Targeting inflammation: multiple innovative ways to reduce prostaglandin E₂

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Non-steroidal anti-inflammatory drugs for heavy menstrual bleeding

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COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression

20 March 2017

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Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP(2)

20 March 2017

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Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT)

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20 March 2017

Prostaglandin E synthase

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Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes

21 January 2018

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cDNA cloning, expression and characterization of human prostaglandin F synthase

20 March 2017

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Soluble epoxide hydrolase in atherosclerosis

20 March 2017

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Timing of sexual intercourse in relation to ovulation. Effects on the probability of conception, survival of the pregnancy, and sex of the baby

20 March 2017

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A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP

20 March 2017

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Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus

20 March 2017

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15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer

20 March 2017

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Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2

20 March 2017

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Involvement of cytosolic phospholipase A2 in the ovulatory process in gonadotropin-primed immature rats

20 March 2017

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The functions of five distinct mammalian phospholipase A2S in regulating arachidonic acid release. Type IIa and type V secretory phospholipase A2S are functionally redundant and act in concert with cytosolic phospholipase A2

20 March 2017

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20 March 2017

Cyclooxygenases 1 and 2

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Prostanoid receptors: structures, properties, and functions

7 April 2017

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Estrogen promotes luteolysis by redistributing prostaglandin F2α receptors within primate luteal cells

27 November 2018

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Emergency contraception. Widely available and effective but disappointing as a public health intervention: a review

29 September 2017

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Angiogenesis in the primate ovulatory follicle is stimulated by luteinizing hormone via prostaglandin E2.

29 September 2017

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Preferential Cyclooxygenase 2 Inhibitors as a Nonhormonal Method of Emergency Contraception: A Look at the Evidence

29 September 2017

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Localization of luteinizing hormone receptor protein in the human ovary

29 September 2017

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Inactivating mutation in the prostaglandin transporter gene, SLCO2A1, associated with familial digital clubbing, colon neoplasia, and NSAID resistance

29 September 2017

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A prostaglandin E2 receptor antagonist prevents pregnancies during a preclinical contraceptive trial with female macaques

29 September 2017

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Characterization of the human cumulus cell transcriptome during final follicular maturation and ovulation.

29 September 2017

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Genetic variability in key genes in prostaglandin E2 pathway (COX-2, HPGD, ABCC4 and SLCO2A1) and their involvement in colorectal cancer development

29 September 2017

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Identification of new ovulation-related genes in humans by comparing the transcriptome of granulosa cells before and after ovulation triggering in the same controlled ovarian stimulation cycle.

29 September 2017

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Prostaglandin E2 (EP) receptors mediate PGE2-specific events in ovulation and luteinization within primate ovarian follicles

29 September 2017

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Characterization of microsomal prostaglandin E synthase 1 inhibitors

29 September 2017

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Inflammation and diabetes-accelerated atherosclerosis: myeloid cell mediators.

29 September 2017

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Emergency contraception: clinical outcomes

29 September 2017

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Impact of the prostaglandin synthase-2 inhibitor celecoxib on ovulation and luteal events in women

29 September 2017

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Group IVA phospholipase A₂ optimizes ovulation and fertilization in rodents through induction of and metabolic coupling with prostaglandin endoperoxide synthase 2.

29 September 2017

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Identification and development of mPGES-1 inhibitors: where we are at?

29 September 2017

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Prostaglandin catabolic enzymes as tumor suppressors

29 September 2017

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15-Hydroxyprostaglandin dehydrogenase as a novel molecular target for cancer chemoprevention and therapy

29 September 2017

1 reference

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Expression and localization of the 20α-hydroxysteroid dehydrogenase (HSD) enzyme in the reproductive tissues of the cynomolgus monkey Macaca fascicularis

29 September 2017

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Prostaglandin E2 receptors are differentially expressed in subpopulations of granulosa cells from primate periovulatory follicles

29 September 2017

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Inhibitors of aldo-keto reductases AKR1C1-AKR1C4.

29 September 2017

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Maturation and fertilization of nonhuman primate oocytes are compromised by oral administration of a cyclooxygenase-2 inhibitor

29 September 2017

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Recent progress in phospholipase A₂ research: from cells to animals to humans

29 September 2017

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Prostaglandin dehydrogenase (PGDH) in granulosa cells of primate periovulatory follicles is regulated by the ovulatory gonadotropin surge via multiple G proteins

29 September 2017

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Mammalian oocytes are targets for prostaglandin E2 (PGE2) action

29 September 2017

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Prostaglandin E2: the master of endometriosis?

29 September 2017

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Prostaglandin E2 at new glance: novel insights in functional diversity offer therapeutic chances.

29 September 2017

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Expression of prostaglandin metabolising enzymes COX-2 and 15-PGDH and VDR in human granulosa cells.

29 September 2017

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Regulation of prostaglandin transporters in colorectal neoplasia

29 September 2017

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The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

29 September 2017

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Two pathways for prostaglandin F2 alpha synthesis by the primate periovulatory follicle

29 September 2017

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Expression of 15-PGDH is downregulated by COX-2 in gastric cancer

29 September 2017

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15-hydroxyprostaglandin dehydrogenase (15-PGDH) and lung cancer

29 September 2017

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Cyclooxygenase enzyme expression and E series prostaglandin receptor signalling are enhanced in heavy menstruation

29 September 2017

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Prostaglandin receptors are mediators of vascular function in endometrial pathologies.

29 September 2017

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NAD+-linked 15-hydroxyprostaglandin dehydrogenase: structure and biological functions

29 September 2017

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Advances in the management of endometriosis: an update for clinicians

29 September 2017

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Identification of a new class of prostaglandin transporter inhibitors and characterization of their biological effects on prostaglandin E2 transport

29 September 2017

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Association between the current use of low-dose oral contraceptives and cardiovascular arterial disease: a meta-analysis

29 September 2017

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Cyclooxygenase-2 and its role in ovulation: a 2004 account.

29 September 2017

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The two-step model of prostaglandin signal termination: in vitro reconstitution with the prostaglandin transporter and prostaglandin 15 dehydrogenase

29 September 2017

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Comparison of the incidence rates of thromboembolic events reported for patients prescribed celecoxib and meloxicam in general practice in England using Prescription-Event Monitoring (PEM) data

29 September 2017

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The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs

29 September 2017

1 reference

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Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2.

29 September 2017

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Comparison of the incidence rates of thromboembolic events reported for patients prescribed rofecoxib and meloxicam in general practice in England using prescription-event monitoring (PEM) data

29 September 2017

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The molecular basis of differential subcellular localization of C2 domains of protein kinase C-alpha and group IVa cytosolic phospholipase A2.

29 September 2017

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29 September 2017

Prostaglandin transport

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Phospholipase A(2) regulation of arachidonic acid mobilization

29 September 2017

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Characterization of a novel inhibitor of cytosolic phospholipase A2alpha, pyrrophenone

29 September 2017

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Oral contraceptives and the risk of myocardial infarction

29 September 2017

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The coxibs, selective inhibitors of cyclooxygenase-2.

29 September 2017

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Oral contraceptives and the risk of venous thrombosis

29 September 2017

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Growth differentiation factor-9 stimulates progesterone synthesis in granulosa cells via a prostaglandin E2/EP2 receptor pathway

29 September 2017

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The delayed activation of the prostaglandin G/H synthase-2 promoter in bovine granulosa cells is associated with down-regulation of truncated upstream stimulatory factor-2.

29 September 2017

1 reference

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Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor

29 September 2017

1 reference

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Failure of parturition in mice lacking the prostaglandin F receptor

29 September 2017

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Regulation of prostaglandin F2 alpha receptor expression in cultured human granulosa-luteal cells

29 September 2017

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Midcycle administration of a progesterone synthesis inhibitor prevents ovulation in primates

29 September 2017

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Cloning and expression of a cDNA for mouse prostaglandin F receptor.

29 September 2017

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Current status of the hypothesis that mammalian ovulation is comparable to an inflammatory reaction

29 September 2017

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Characteristics of the menstrual cycle in nonhuman primates. II. Ovulation and optimal mating times in macaques

29 September 2017

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Cloning of equine prostaglandin dehydrogenase and its gonadotropin-dependent regulation in theca and mural granulosa cells of equine preovulatory follicles during the ovulatory process

29 September 2017

1 reference

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Differential expression and regulation of prostaglandin E synthases in the mouse ovary during sexual maturation and luteal development.

2 June 2018

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Urogenital distribution of a mouse membrane-associated prostaglandin E(2) synthase

2 June 2018

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Molecular cloning and induction of bovine prostaglandin E synthase by gonadotropins in ovarian follicles prior to ovulation in vivo

2 June 2018

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Subcellular localization of prostaglandin endoperoxide H synthases-1 and -2 by immunoelectron microscopy

2 June 2018

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Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2.

2 June 2018

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Induction of cyclooxygenase-2 and prostaglandin F2alpha receptor expression by interleukin-1beta in cultured human granulosa-luteal cells

2 June 2018

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Ovarian expression, cellular localization, and hormonal regulation of rat secretory phospholipase A2: increased expression by interleukin-1 and by gonadotropins

2 June 2018

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Indomethacin inhibition of ovulation in the cow.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626744

Ovarian follicular fluid eicosanoid concentrations during the pre-ovulatory period in humans

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626744

Changes in rat ovarian carbonyl reductase activity and content during the estrous cycle, and localization

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626744

Localization of luteinizing hormone receptor messenger ribonucleic acid expression in ovarian cell types during follicle development and ovulation.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626744

The use of a urinary estrone conjugates assay for detection of optimal mating time in the cynomolgus macaque (Macaca fascicularis).

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626744

Evidence for two antigenically distinct molecular weight variants of prostaglandin H synthase in the rat ovary

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626744

Delay of ovulation by meloxicam in healthy cycling volunteers: A placebo-controlled, double-blind, crossover study.

2 June 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Development of nonsteroidal anti-inflammatory drug analogs and steroid carboxylates selective for human aldo-keto reductase isoforms: potential antineoplastic agents that work independently of cyclooxygenase isozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Human chorionic gonadotropin-dependent induction of an equine aldo-keto reductase (AKR1C23) with 20alpha-hydroxysteroid dehydrogenase activity during follicular luteinization in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Identification of lactate as a driving force for prostanoid transport by prostaglandin transporter PGT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Expression of phospholipase A2 group IVA (PLA2G4A) is upregulated by human chorionic gonadotropin in bovine granulosa cells of ovulatory follicles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

The ovulatory gonadotrophin surge stimulates cyclooxygenase expression and prostaglandin production by the monkey follicle

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Follicular administration of a cyclooxygenase inhibitor can prevent oocyte release without alteration of normal luteal function in rhesus monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Luteinizing hormone acts directly at granulosa cells to stimulate periovulatory processes: modulation of luteinizing hormone effects by prostaglandins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

An ovulatory gonadotropin stimulus increases cytosolic phospholipase A2 expression and activity in granulosa cells of primate periovulatory follicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Microsomal prostaglandin E synthase-1 (mPGES-1) is the primary form of PGES expressed by the primate periovulatory follicle

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Prostaglandin dehydrogenase and prostaglandin levels in periovulatory follicles: implications for control of primate ovulation by prostaglandin E2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

21 January 2018

Emergency Contraception

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Cross-talk between cytosolic phospholipase A2 alpha (cPLA2 alpha) and secretory phospholipase A2 (sPLA2) in hydrogen peroxide-induced arachidonic acid release in murine mesangial cells: sPLA2 regulates cPLA2 alpha activity that is responsible for ar

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Oral administration of the cyclooxygenase-2 (COX-2) inhibitor meloxicam blocks ovulation in non-human primates when administered to simulate emergency contraception

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Suppression of follicular rupture with meloxicam, a cyclooxygenase-2 inhibitor: potential for emergency contraception

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Effect of oral administration of a continuous 18 day regimen of meloxicam on ovulation: experience of a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Expression and cellular distribution of cytosolic phospholipase A2 in the rat ovary.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Inhibition of ovulation by a lipoxygenase inhibitor involves reduced cyclooxygenase-2 expression and prostaglandin E2 production in gonadotropin-primed immature rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Multiple female reproductive failures in cyclooxygenase 2-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Primate granulosa cell response via prostaglandin E2 receptors increases late in the periovulatory interval

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

The COX-2 inhibitor meloxicam prevents pregnancy when administered as an emergency contraceptive to nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Induction of delayed follicular rupture in the human by the selective COX-2 inhibitor rofecoxib: a randomized double-blind study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Inhibition of intrafollicular PGE2 synthesis and ovulation following ultrasound-mediated intrafollicular injection of the selective cyclooxygenase-2 inhibitor NS-398 in cattle

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Incidence of stroke and myocardial infarction in women of reproductive age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Reduction of cPLA2alpha overexpression: an efficient anti-inflammatory therapy for collagen-induced arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Molecular cloning and gonadotropin-dependent regulation of equine prostaglandin F2alpha receptor in ovarian follicles during the ovulatory process in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

Cyclooxygenase-2-derived prostaglandin E(2) directs oocyte maturation by differentially influencing multiple signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

The effect of nonsteroidal anti-inflammatory drugs on ovulation: a prospective, randomized clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMV026

The expression of brain cyclooxygenase-2 is down-regulated in the cytosolic phospholipase A2 knockout mouse

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626744

Cytosolic phospholipase A2alpha is crucial [correction of A2alpha deficiency is crucial] for 'on-time' embryo implantation that directs subsequent development

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626744

Non-steroidal anti-inflammatory drugs as a possible cause for reversible infertility

27 November 2018

1 reference

12 December 2020

Prostaglandin F2alpha-induced expression of 20alpha-hydroxysteroid dehydrogenase involves the transcription factor NUR77

1 reference

12 December 2020

NSAID use and the risk of hospitalization for first myocardial infarction in the general population: a nationwide case-control study from Finland

1 reference

12 December 2020

Effects of indomethacin on follicular structure, vascularity, and function over the periovulatory period in women

1 reference

12 December 2020

Effect of time and dose of indomethacin on follicular prostaglandins and ovulation in the rabbit

1 reference

12 December 2020

Interactive roles of progesterone, prostaglandins, and collagenase in the ovulatory mechanism of the ewe

1 reference

12 December 2020

Pharmacologic production of luteinized unruptured follicles by prostaglandin synthetase inhibitors

1 reference

12 December 2020

Inhibition of follicle-stimulating hormone-induced ovulation by indomethacin in the perfused rat ovary

1 reference

12 December 2020

Prostaglandin endoperoxide synthase in rat ovarian follicles: content, cellular distribution, and evidence for hormonal induction preceding ovulation

1 reference

12 December 2020

Partial purification of prostaglandin E2-9-ketoreductase and prostaglandin-15-hydroxydehydrogenase from ovarian tissues of rabbits

1 reference

12 December 2020

Studies on the mechanism of ovulation using the model of the isolated ovary

1 reference

12 December 2020

Prostaglandin E2-9-ketoreductase activity of preovulatory ovine follicles

1 reference

12 December 2020

Ovarian prostaglandin endoperoxide synthase: cellular localization during the rat estrous cycle

1 reference

12 December 2020

The effect of prostaglandin synthetase inhibitors on human preovulatory follicular fluid prostaglandin, thromboxane, and leukotriene concentrations

1 reference

12 December 2020

Hormonal control of ovarian phospholipase A2 activity in rats

1 reference

12 December 2020

Induction of prostaglandin endoperoxide synthase-2 by human chorionic gonadotropin in bovine preovulatory follicles in vivo

1 reference

12 December 2020

Calcium-mediated translocation of cytosolic phospholipase A2 to the nuclear envelope and endoplasmic reticulum

1 reference

12 December 2020

Infertility may sometimes be associated with NSAID consumption

1 reference

12 December 2020

Reversible ovulatory failure associated with the development of luteinized unruptured follicles in women with inflammatory arthritis taking non-steroidal anti-inflammatory drugs

1 reference

12 December 2020

Regulation, action and transport of prostaglandins during the periovulatory period in cattle

1 reference

12 December 2020

Does meloxicam increase the incidence of anovulation induced by single administration of levonorgestrel in emergency contraception? A pilot study

1 reference

12 December 2020

Physiological role of prostaglandins in the induction of ovulation

1 reference

12 December 2020

Effectiveness of prostaglandin F2α in restoration of HMG-HCG induced ovulation in indomethacin-treated rhesus monkeys

1 reference

12 December 2020

The effect of indomethacin on HMG-HCG induced ovulation in the rhesus monkey

1 reference

12 December 2020

Periovulatory changes in ovarian prostaglandin formation and their hormonal control in the rat

1 reference

12 December 2020

Effects of indomethacin on preovulatory follicles in immature, superovulated mice

1 reference

12 December 2020

Prostaglandins and preovulatory follicular maturation in mice

1 reference

12 December 2020

Blockade of spontaneous and LH-induced ovulation in rats by indomethacin, an inhibitor of prostaglandin biosynthesis

1 reference

12 December 2020

Prostaglandin G/H synthase-2 is expressed in bovine preovulatory follicles after the endogenous surge of luteinizing hormone

1 reference

12 December 2020

The lipoxygenase inhibitor, nordihydroguaiaretic acid, inhibits ovulation and reduces leukotriene and prostaglandin levels in the rat ovary

1 reference

12 December 2020

The selective prostaglandin endoperoxide synthase-2 inhibitor, NS-398, reduces prostaglandin production and ovulation in vivo and in vitro in the rat

1 reference

12 December 2020

Sounding the alarm--does induction of prostaglandin endoperoxide synthase-2 control the mammalian ovulatory clock?

1 reference

12 December 2020

The late induction of prostaglandin G/H synthase-2 in equine preovulatory follicles supports its role as a determinant of the ovulatory process

1 reference

12 December 2020