Molecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cells (Q28081405)

main subject

neoplastic stem cells

1 reference

V. Justilien

1

1 reference

Crossref

A. P. Fields

series ordinal

2

1 reference

Crossref

language of work or name

1 reference

1 February 2015

1 reference

published in

Clinical Cancer Research

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volume

21

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issue

3

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page(s)

505-13

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The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma

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Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

20 March 2017

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Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein

20 March 2017

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Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma

20 March 2017

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Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells

20 March 2017

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Identification of an amplified, highly expressed gene in a human glioma

20 March 2017

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Chemoresistance in prostate cancer cells is regulated by miRNAs and Hedgehog pathway

20 March 2017

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The primary cilium: a signalling centre during vertebrate development

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Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

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Patched1 regulates hedgehog signaling at the primary cilium

7 April 2017

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A restricted cell population propagates glioblastoma growth after chemotherapy

7 April 2017

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CD44 expression denotes a subpopulation of gastric cancer cells in which Hedgehog signaling promotes chemotherapy resistance

7 April 2017

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Crosstalk between hedgehog and other signaling pathways as a basis for combination therapies in cancer

29 September 2017

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Atypical protein kinase Cι as a human oncogene and therapeutic target

29 September 2017

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Emerging landscape of oncogenic signatures across human cancers

29 September 2017

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Smoothened inhibition leads to decreased proliferation and induces apoptosis in esophageal adenocarcinoma cells

29 September 2017

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Hedgehog targeting by cyclopamine suppresses head and neck squamous cell carcinoma and enhances chemotherapeutic effects

29 September 2017

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The mechanisms of Hedgehog signalling and its roles in development and disease

29 September 2017

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Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation

29 September 2017

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GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas.

29 September 2017

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Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling

29 September 2017

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Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO

29 September 2017

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A randomized phase II trial of vismodegib versus placebo with FOLFOX or FOLFIRI and bevacizumab in patients with previously untreated metastatic colorectal cancer

29 September 2017

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A phase II, randomized, placebo-controlled study of vismodegib as maintenance therapy in patients with ovarian cancer in second or third complete remission.

29 September 2017

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Suppression of acquired docetaxel resistance in prostate cancer through depletion of notch- and hedgehog-dependent tumor-initiating cells.

29 September 2017

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Inhibition of hedgehog signaling depresses self-renewal of pancreatic cancer stem cells and reverses chemoresistance

29 September 2017

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Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas

29 September 2017

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Embryonic signaling pathways and rhabdomyosarcoma: contributions to cancer development and opportunities for therapeutic targeting

29 September 2017

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Smoothened antagonists reverse taxane resistance in ovarian cancer

29 September 2017

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Sonic Hedgehog pathway is essential for neuroblastoma cell proliferation and tumor growth

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

In vitro and in vivo characterization of a novel Hedgehog signaling antagonist in human glioblastoma cell lines.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

A crucial requirement for Hedgehog signaling in small cell lung cancer

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer

29 September 2017

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Polymeric nanoparticle-encapsulated hedgehog pathway inhibitor HPI-1 (NanoHHI) inhibits systemic metastases in an orthotopic model of human hepatocellular carcinoma

29 September 2017

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Gli proteins in development and disease

29 September 2017

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Hedgehog signaling and pancreatic tumor development

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer.

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Hedgehog signaling drives cellular survival in human colon carcinoma cells

29 September 2017

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Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance

29 September 2017

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Hedgehog signaling maintains chemoresistance in myeloid leukemic cells.

29 September 2017

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Targeting Hedgehog--a cancer stem cell pathway

29 September 2017

1 reference

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The role of the hedgehog signaling pathway in the development of basal cell carcinoma and opportunities for treatment

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Smoothened as a new therapeutic target for human osteosarcoma

29 September 2017

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Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

29 September 2017

1 reference

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The sonic hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growth

29 September 2017

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Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

29 September 2017

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Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

29 September 2017

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Paracrine Hedgehog signaling in cancer

29 September 2017

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A critical role of Sonic Hedgehog signaling in maintaining the tumorigenicity of neuroblastoma cells

29 September 2017

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Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.

29 September 2017

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Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

29 September 2017

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Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer

29 September 2017

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Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process

29 September 2017

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Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Role of hedgehog signaling in ovarian cancer

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer.

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

A paracrine requirement for hedgehog signalling in cancer

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Snail and Sonic Hedgehog activation in neuroendocrine tumors of the ileum

29 September 2017

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Essential role of stromally induced hedgehog signaling in B-cell malignancies

29 September 2017

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Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

29 September 2017

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Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Sonic Hedgehog promotes multiple drug resistance by regulation of drug transport

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Overexpression of hedgehog signaling molecules and its involvement in the proliferation of endometrial carcinoma cells

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: it's inhibition leads to growth suppression and apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Integrative genomic analysis of protein kinase C (PKC) family identifies PKCiota as a biomarker and potential oncogene in ovarian carcinoma.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Hedgehog signalling in prostate regeneration, neoplasia and metastasis

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

29 September 2017

1 reference

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Novel genes regulated by Sonic Hedgehog in pluripotent mesenchymal cells

29 September 2017

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Defining the mode of tumour growth by clonal analysis

29 September 2017

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Reduction of human embryonal rhabdomyosarcoma tumor growth by inhibition of the hedgehog signaling pathway

2 June 2018

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Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.

2 June 2018

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Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

2 June 2018

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Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers

2 June 2018

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Amplification of the gli gene in childhood sarcomas.

2 June 2018

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Hedgehog signaling is active in human prostate cancer stroma and regulates proliferation and differentiation of adjacent epithelium.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Hedgehog pathway regulators influence cervical cancer cell proliferation, survival and migration

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Hedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: a potential new therapeutic target

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Hedgehog signaling is activated in subsets of esophageal cancers

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

GLI3 frameshift mutations cause autosomal dominant Pallister-Hall syndrome

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382

Congenital Deformities in Lambs, Calves, and Goats Resulting from Maternal Ingestion ofVeratrum californicum; Hare Lip, Cleft Palate, Ataxia, and Hypoplasia of Metacarpal and Metatarsal Bones

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/25646180

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25646180