3D culture models of Alzheimer's disease: a road map to a "cure-in-a-dish" (Q28078900)

Young Hye Kim

series ordinal

2

1 reference

Luisa Quinti

series ordinal

3

1 reference

Molecular Neurodegeneration

language of work or name

1 reference

9 December 2016

5 references

25 April 2019

29 June 2019

19 September 2019

12 October 2019

5 references

25 April 2019

29 June 2019

19 September 2019

12 October 2019

11

1 reference

issue

1

1 reference

page(s)

75

1 reference

Creative Commons Attribution 4.0 International

copyright license

4 references

25 April 2019

29 June 2019

19 September 2019

on focus list of Wikimedia project

12 October 2019

copyright status

copyrighted

0 references

ScienceSource

0 references

exact match

https://scigraph.springernature.com/pub.10.1186/s13024-016-0139-7

0 references

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The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

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Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

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29 September 2017

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Establishment of induced pluripotent stem cell (iPSC) line from an 84-year old patient with late onset Alzheimer's disease (LOAD).

29 September 2017

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Establishment of induced pluripotent stem cell (iPSC) line from a 57-year old patient with sporadic Alzheimer's disease

29 September 2017

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29 September 2017

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29 September 2017

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The amyloid cascade hypothesis: are we poised for success or failure?

29 September 2017

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29 September 2017

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Complement and microglia mediate early synapse loss in Alzheimer mouse models.

29 September 2017

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Recapitulating amyloid β and tau pathology in human neural cell culture models: clinical implications

29 September 2017

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The role of calsyntenin-3 in dystrophic neurite formation in Alzheimer's disease brain

29 September 2017

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Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease

29 September 2017

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Single-Cell Detection of Secreted Aβ and sAPPα from Human IPSC-Derived Neurons and Astrocytes.

29 September 2017

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Human Induced Pluripotent Stem Cell Derived Neuronal Cells Cultured on Chemically-Defined Hydrogels for Sensitive In Vitro Detection of Botulinum Neurotoxin.

29 September 2017

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Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells

29 September 2017

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Direct Conversion of Normal and Alzheimer's Disease Human Fibroblasts into Neuronal Cells by Small Molecules

29 September 2017

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Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations.

29 September 2017

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Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT

29 September 2017

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A 3D human neural cell culture system for modeling Alzheimer's disease

29 September 2017

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Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

29 September 2017

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2015 Alzheimer's disease facts and figures

29 September 2017

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APP metabolism regulates tau proteostasis in human cerebral cortex neurons

29 September 2017

1 reference

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Differentiation of neuroepithelial stem cells into functional dopaminergic neurons in 3D microfluidic cell culture

29 September 2017

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On human pluripotent stem cell control: The rise of 3D bioengineering and mechanobiology.

29 September 2017

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Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks

29 September 2017

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BACE1 inhibitor drugs in clinical trials for Alzheimer's disease

29 September 2017

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Blood-brain barrier breakdown in the aging human hippocampus

29 September 2017

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A critical analysis of the 'amyloid cascade hypothesis'.

29 September 2017

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Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers

29 September 2017

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Bioengineered functional brain-like cortical tissue

29 September 2017

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29 September 2017

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Familial Alzheimer's disease modelling using induced pluripotent stem cell technology

29 September 2017

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29 September 2017

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The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

29 September 2017

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Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors

29 September 2017

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Stem cell derived basal forebrain cholinergic neurons from Alzheimer's disease patients are more susceptible to cell death

29 September 2017

1 reference

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A review of microfabrication and hydrogel engineering for micro-organs on chips

29 September 2017

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The presenilin-1 ΔE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells

29 September 2017

1 reference

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3D differentiation of neural stem cells in macroporous photopolymerizable hydrogel scaffolds

29 September 2017

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A brief history of Alzheimer's disease gene discovery

29 September 2017

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A human stem cell model of early Alzheimer's disease pathology in Down syndrome

29 September 2017

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The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

29 September 2017

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Self-formation of functional adenohypophysis in three-dimensional culture.

29 September 2017

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Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus.

29 September 2017

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Effect of 3D-scaffold formation on differentiation and survival in human neural progenitor cells.

29 September 2017

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Selecting a mouse model of Alzheimer's disease

29 September 2017

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Tau in Alzheimer disease and related tauopathies

29 September 2017

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Matrigel: a complex protein mixture required for optimal growth of cell culture.

29 September 2017

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Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses

29 September 2017

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Animal models of Alzheimer's disease and frontotemporal dementia

29 September 2017

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29 September 2017

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Frontotemporal dementia with tau pathology.

29 September 2017

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Differential development of neuronal physiological responsiveness in two human neural stem cell lines

29 September 2017

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Transgenic mice overexpressing reticulon 3 develop neuritic abnormalities

29 September 2017

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The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism

29 September 2017

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Regulation of tau isoform expression and dementia

29 September 2017

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The role of tau in Alzheimer's disease

29 September 2017

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Progress in the modeling of neurodegenerative diseases in transgenic mice

29 September 2017

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Review of the next generation of Alzheimer's disease therapeutics: challenges for drug development

29 September 2017

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Isolation and characterization of type IV procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma.

29 September 2017

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Alteration of neuritic cytoarchitecture in Alzheimer disease

29 September 2017

1 reference

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Establishment of PSEN1 mutant induced pluripotent stem cell (iPSC) line from an Alzheimer's disease (AD) female patient.

29 September 2017

1 reference

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Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying an A79V mutation in PSEN1.

2 June 2018

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Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease

2 June 2018

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Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein

2 June 2018

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A three-dimensional human neural cell culture model of Alzheimer's disease

2 June 2018

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Differentiation of human neural progenitor cells in functionalized hydrogel matrices

2 June 2018

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Modeling familial Alzheimer's disease with induced pluripotent stem cells

2 June 2018

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Accelerated human mutant tau aggregation by knocking out murine tau in a transgenic mouse model

2 June 2018

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Lessons from a failed γ-secretase Alzheimer trial.

2 June 2018

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Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation.

21 January 2018

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Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness

21 January 2018

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Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9.

21 January 2018

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The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS13024-016-0139-7

Dystrophic neurites in TgCRND8 and Tg2576 mice mimic human pathological brain aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS13024-016-0139-7

Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS13024-016-0139-7

Single App knock-in mouse models of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS13024-016-0139-7

Modeling the Blood-Brain Barrier in a 3D triple co-culture microfluidic system.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148918

Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/27938410