Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis (Q27933360)

GOA release 2020-03-11

author name string

Eric J Solís

1

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Jai P Pandey

2

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Xu Zheng

3

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Dexter X Jin

4

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Piyush B Gupta

5

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Edoardo M Airoldi

6

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David Pincus

7

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Vladimir Denic

A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress

8

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language of work or name

English

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publication date

7 July 2016

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1 reference

1 December 2016

63

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issue

1

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page(s)

60-71

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cites work

1 reference

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Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress

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MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1.

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HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers

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