Caspase-8 expression is predictive of tumour response to death receptor 5 agonist antibody in Ewing's sarcoma (Q27853200)

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Caspase-8 expression is predictive of tumour response to death receptor 5 agonist antibody in Ewing’s sarcoma

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English	Caspase-8 expression is predictive of tumour response to death receptor 5 agonist antibody in Ewing's sarcoma	scientific article	Caspase-8 expression is predictive of tumour response to death receptor 5 agonist antibody in Ewing’s sarcoma

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scholarly article

2 references

13 November 2016

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26291055%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Caspase-8 expression is predictive of tumour response to death receptor 5 agonist antibody in Ewing's sarcoma (English)

2 references

13 November 2016

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26291055%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1

1 reference

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22 February 2020

author name string

Seth D Goldstein

2

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22 February 2020

Yunkai Yu

3

1 reference

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22 February 2020

Paul S Meltzer

4

1 reference

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22 February 2020

David M Loeb

5

1 reference

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22 February 2020

Liang Cao

6

1 reference

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22 February 2020

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20 August 2015

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22 February 2020

British Journal of Cancer

1 reference

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22 February 2020

113

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22 February 2020

6

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22 February 2020

894-901

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22 February 2020

copyright license

Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International

20 August 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Apo2L/TRAIL and the death receptor 5 agonist antibody AMG 655 cooperate to promote receptor clustering and antitumor activity

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20 March 2017

Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling

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20 March 2017

Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5

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20 March 2017

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

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20 March 2017

Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8

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20 March 2017

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20 March 2017

TRAIL-R2-specific antibodies and recombinant TRAIL can synergise to kill cancer cells

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29 September 2017

A randomized phase 2 study of paclitaxel and carboplatin with or without conatumumab for first-line treatment of advanced non-small-cell lung cancer

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29 September 2017

A functional, new short isoform of death receptor 4 in Ewing's sarcoma cell lines may be involved in TRAIL sensitivity/resistance mechanisms

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29 September 2017

Drozitumab, a human antibody to death receptor 5, has potent antitumor activity against rhabdomyosarcoma with the expression of caspase-8 predictive of response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4578089

29 September 2017

An Fcγ receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells

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29 September 2017

Phase I dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer

1 reference

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29 September 2017

Conatumumab, a fully human agonist antibody to death receptor 5, induces apoptosis via caspase activation in multiple tumor types

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4578089

29 September 2017

Mapatumumab and lexatumumab induce apoptosis in TRAIL-R1 and TRAIL-R2 antibody-resistant NSCLC cell lines when treated in combination with bortezomib

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29 September 2017

TRAIL resistance of breast cancer cells is associated with constitutive endocytosis of death receptors 4 and 5.

1 reference

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29 September 2017

Cooperation of the agonistic DR5 antibody apomab with chemotherapy to inhibit orthotopic lung tumor growth and improve survival

1 reference

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29 September 2017

Directing cancer cells to self-destruct with pro-apoptotic receptor agonists

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29 September 2017

Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody

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29 September 2017

To kill a tumor cell: the potential of proapoptotic receptor agonists

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29 September 2017

Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy

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29 September 2017

Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL.

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29 September 2017

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29 September 2017

Apoptotic responsiveness of the Ewing's sarcoma family of tumours to tumour necrosis factor-related apoptosis-inducing ligand (TRAIL).

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29 September 2017

Death-effector filaments: novel cytoplasmic structures that recruit caspases and trigger apoptosis

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29 September 2017

A randomized, placebo-controlled phase 2 study of ganitumab or conatumumab in combination with FOLFIRI for second-line treatment of mutant KRAS metastatic colorectal cancer

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2 June 2018

Prognostic factors in Ewing's tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group

1 reference

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2 June 2018

Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

1 reference

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2 June 2018

First-line treatment of metastatic or locally advanced unresectable soft tissue sarcomas with conatumumab in combination with doxorubicin or doxorubicin alone: a phase I/II open-label and double-blind study.

1 reference

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21 January 2018

Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer

1 reference

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21 January 2018

Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival.

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21 January 2018

Preclinical evidence that use of TRAIL in Ewing's sarcoma and osteosarcoma therapy inhibits tumor growth, prevents osteolysis, and increases animal survival

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21 January 2018

Ewing's sarcoma family tumors are sensitive to tumor necrosis factor-related apoptosis-inducing ligand and express death receptor 4 and death receptor 5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4578089

27 November 2018

Ewing's sarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/26291055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A first-in-human study of conatumumab in adult patients with advanced solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26291055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/BJC.2015.298

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26291055%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

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2 references

13 November 2016

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26291055%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

2 references

13 November 2016

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26291055%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

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