Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells (Q27824846)

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English	Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells	scientific article

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scholarly article

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13 November 2016

Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells (English)

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13 November 2016

apoptotic process

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based on heuristic

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based on heuristic

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author name string

Wenle Xia

1

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Catherine M Gerard

2

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Leihua Liu

3

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Nathalie M Baudson

4

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Thierry L Ory

5

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Neil L Spector

6

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language of work or name

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publication date

15 September 2005

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24

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6213-21

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41

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Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth

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ErbB-targeted therapeutic approaches in human cancer

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Cytokine-regulated expression of survivin in myeloid leukemia

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Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets

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Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease

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Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2.

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

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Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members

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Mechanism of action of erbB tyrosine kinase inhibitors

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c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes

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Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity

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The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation

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21 January 2018

Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): combining anti-EGFR antibody with tyrosine kinase inhibitor.

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Pleiotropic cell-division defects and apoptosis induced by interference with survivin function

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HBXIP functions as a cofactor of survivin in apoptosis suppression

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Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): superiority over single-agent receptor targeting.

1 reference

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21 January 2018

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

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21 January 2018

Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers

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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

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Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

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21 January 2018

Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis

1 reference

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Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer

1 reference

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Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

1 reference

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Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer

1 reference

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21 January 2018

A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells

1 reference

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21 January 2018

Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways

1 reference

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21 January 2018

Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016.

1 reference

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21 January 2018

Untangling the ErbB signalling network

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21 January 2018

Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway

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7 January 2021

based on heuristic

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The effect of antibodies and immunotoxins reactive with HER-2/neu on growth of ovarian and breast cancer cell lines

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7 January 2021

based on heuristic

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Identifiers

10.1038/SJ.ONC.1208774

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

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Springer Nature article ID

10.1038/sj.onc.1208774

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