NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine (Q27727699)

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21 March 2020

title

NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine (English)

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21 March 2020

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21 March 2020

Ann-Sofie Jemth

12

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21 March 2020

Nicholas Valerie

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21 March 2020

Geoffrey Masuyer

4

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21 March 2020

Patrick Herr

8

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21 March 2020

9

Evert Homan

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21 March 2020

2

Anna Hagenkort

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21 March 2020

7

Luka Bevc

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21 March 2020

author name string

Brent D G Page

3

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21 March 2020

Daniel Rehling

5

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21 March 2020

Megan Carter

6

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21 March 2020

Nina G Sheppard

10

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21 March 2020

Thomas Helleday

13

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21 March 2020

language of work or name

English

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publication date

16 August 2016

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21 March 2020

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21 March 2020

volume

76

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21 March 2020

issue

18

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21 March 2020

page(s)

5501-5511

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Inhibition of phosphoribosyl pyrophosphate amidotransferase from Ehrlich ascites-tumour cells by thiopurine nucleotides

21 March 2020

cites work

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12 December 2020

The CCP4 suite: programs for protein crystallography

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12 December 2020

Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia

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12 December 2020

Molecular chaperones in protein folding and proteostasis

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12 December 2020

Peripheral blood mononuclear cell DNA 6-thioguanine metabolite levels correlate with decreased interferon-gamma production in patients with Crohn's disease on AZA therapy

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12 December 2020

Effects of 6-thioguanine and S6-methylthioguanine on transcription in vitro and in human cells

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12 December 2020

A novel fluorescence-based assay for the rapid detection and quantification of cellular deoxyribonucleoside triphosphates.

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12 December 2020

Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase

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12 December 2020

MolProbity: all-atom structure validation for macromolecular crystallography

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12 December 2020

Utilization of 2'-deoxy-6-thioguanosine 5'-triphosphate in DNA synthesis in vitro by DNA polymerase alpha from calf thymus

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12 December 2020

Refinement of macromolecular structures by the maximum-likelihood method

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12 December 2020

Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint

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12 December 2020

Ethnic variation of thiopurine S-methyltransferase activity: a large, prospective population study.

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12 December 2020

Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine.

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12 December 2020

Optimizing 6-mercaptopurine and azathioprine therapy in the management of inflammatory bowel disease

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12 December 2020

Mercaptopurine/Methotrexate maintenance therapy of childhood acute lymphoblastic leukemia: clinical facts and fiction

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12 December 2020

A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia

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12 December 2020

Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia

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12 December 2020

Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia

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12 December 2020

DNA mismatch repair (MMR) mediates 6-thioguanine genotoxicity by introducing single-strand breaks to signal a G2-M arrest in MMR-proficient RKO cells

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12 December 2020

Studies on analogs of purines and pyrimidines

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12 December 2020

Quantitation of 6-thioguanine residues in peripheral blood leukocyte DNA obtained from patients receiving 6-mercaptopurine-based maintenance therapy

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12 December 2020

Mismatch repair-dependent iterative excision at irreparable O6-methylguanine lesions in human nuclear extracts

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12 December 2020

The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

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12 December 2020

In vivo ubiquitination and proteasome-mediated degradation of p53(1)

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12 December 2020

FastCloning: a highly simplified, purification-free, sequence- and ligation-independent PCR cloning method

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12 December 2020

Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides

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12 December 2020

NUDT15 R139C causes thiopurine-induced early severe hair loss and leukopenia in Japanese patients with IBD.

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12 December 2020

CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses.

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12 December 2020

Update on thiopurine pharmacogenetics in inflammatory bowel disease

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12 December 2020

Thiopurines, DNA damage, DNA repair and therapy-related cancer

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12 December 2020

Features and development of Coot

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12 December 2020

DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.

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12 December 2020

Mechanisms of action of 6-thioguanine, 6-mercaptopurine, and 8-azaguanine

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12 December 2020

Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation

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12 December 2020

NUDT15 c.415C>T increases risk of 6-mercaptopurine induced myelosuppression during maintenance therapy in children with acute lymphoblastic leukemia.

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12 December 2020

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity

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12 December 2020

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

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12 December 2020

Assessment of thiopurine methyltransferase activity in patients prescribed azathioprine or other thiopurine-based drugs

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12 December 2020

Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy

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12 December 2020

2'-Deoxy-6-thioguanosine 5'-triphosphate as a substrate for purified human DNA polymerases and calf thymus terminal deoxynucleotidyltransferase in vitro

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12 December 2020

How good are my data and what is the resolution?

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12 December 2020

Polymorphism of ITPA 94C>A and risk of adverse effects among patients with acute lymphoblastic leukaemia treated with 6-mercaptopurine

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12 December 2020

Physiological concentrations of purines and pyrimidines

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12 December 2020

Tolerance to O6-methylguanine and 6-thioguanine cytotoxic effects: a cross-resistant phenotype in N-methylnitrosourea-resistant Chinese hamster ovary cells

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12 December 2020

Phasercrystallographic software

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12 December 2020

Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer

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12 December 2020

Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia.

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12 December 2020

Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2

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12 December 2020

The activity of the inosine triphosphate pyrophosphatase affects toxicity of 6-mercaptopurine during maintenance therapy for acute lymphoblastic leukemia in Japanese children

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12 December 2020

Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL.

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12 December 2020

Automated protein model building combined with iterative structure refinement

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12 December 2020

10.1158/0008-5472.CAN-16-0584

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27530327%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

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21 March 2020

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