Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5 (Q27714159)

ChEBI release 2020-05-28

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9 June 2020

Matthew L. Hillwig

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9 June 2020

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Amie K Boal

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9 June 2020

author name string

Qin Zhu

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9 June 2020

Ailiena O Maggiolo

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9 June 2020

Nikhil R Ananth

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9 June 2020

Xinyu Liu

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9 June 2020

language of work or name

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August 2016

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published in

Nature Chemical Biology

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9 June 2020

volume

12

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9 June 2020

issue

8

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9 June 2020

page(s)

636-640

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FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes

9 June 2020

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Conformational switch triggered by -ketoglutarate in a halogenase of curacin A biosynthesis

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Structural Analysis of an Open Active Site Conformation of Nonheme Iron Halogenase CytC3

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Mechanism of the C5 Stereoinversion Reaction in the Biosynthesis of Carbapenem Antibiotics

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Discovery of a Promiscuous Non-Heme Iron Halogenase in Ambiguine Alkaloid Biogenesis: Implication for an Evolvable Enzyme Family for Late-Stage Halogenation of Aliphatic Carbons in Small Molecules

25 May 2017

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Aliphatic Halogenase Enables Late-Stage C-H Functionalization: Selective Synthesis of a Brominated Fischerindole Alkaloid with Enhanced Antibacterial Activity

29 September 2017

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Experimental Correlation of Substrate Position with Reaction Outcome in the Aliphatic Halogenase, SyrB2.

29 September 2017

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A new family of iron-dependent halogenases acts on freestanding substrates.

29 September 2017

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Elucidation of the Fe(IV)=O intermediate in the catalytic cycle of the halogenase SyrB2.

29 September 2017

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Substrate placement influences reactivity in non-heme Fe(II) halogenases and hydroxylases

29 September 2017

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Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases

29 September 2017

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Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2.

29 September 2017

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Metamorphic enzyme assembly in polyketide diversification

29 September 2017

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Substrate-triggered formation and remarkable stability of the C-H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2

29 September 2017

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Non-heme Fe(IV)-oxo intermediates

29 September 2017

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29 September 2017

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SyrB2 in syringomycin E biosynthesis is a nonheme FeII alpha-ketoglutarate- and O2-dependent halogenase

29 September 2017

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29 September 2017

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Identification and characterization of a welwitindolinone alkaloid biosynthetic gene cluster in the stigonematalean Cyanobacterium Hapalosiphon welwitschii.

29 September 2017

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Biosynthetic chlorination of the piperazate residue in kutzneride biosynthesis by KthP.

2 June 2018

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Biosynthesis of (-)-(1S,2R)-allocoronamic acyl thioester by an Fe(II)-dependent halogenase and a cyclopropane-forming flavoprotein

2 June 2018

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Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis

2 June 2018

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Oxidative halogenation with "green" oxidants: oxygen and hydrogen peroxide

21 January 2018

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Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3

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12 December 2020

Biosynthesis of ambiguine indole alkaloids in cyanobacterium Fischerella ambigua

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12 December 2020

One motif--many different reactions

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12 December 2020

More than just a Halogenase: Modification of Fatty Acyl Moieties by a Trifunctional Metal Enzyme

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12 December 2020

Halogenation of unactivated carbon centers in natural product biosynthesis: trichlorination of leucine during barbamide biosynthesis

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Why does the enzyme SyrB2 chlorinate, but does not hydroxylate, saturated hydrocarbons? A density functional theory (DFT) study

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Identifiers

DOI

10.1038/NCHEMBIO.2112

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348090%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

9 June 2020

0 references

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9 June 2020

1 reference