Switching demethylation activities between AlkB family RNA/DNA demethylases through exchange of active-site residues (Q27689434)

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9 March 2020

title

Switching demethylation activities between AlkB family RNA/DNA demethylases through exchange of active-site residues (English)

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9 March 2020

1

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9 March 2020

Chengqi Yi

series ordinal

2

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9 March 2020

author name string

Chenxu Zhu

series ordinal

1

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Chengqi Yi

series ordinal

2

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language of work or name

English

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publication date

5 March 2014

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Angewandte Chemie International Edition

9 March 2020

published in

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9 March 2020

volume

53

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9 March 2020

issue

14

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9 March 2020

page(s)

3659-3662

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TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

9 March 2020

cites work

1 reference

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Nucleic acid modifications with epigenetic significance

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AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli

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Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage

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Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA

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AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation

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Substrate specificities of bacterial and human AlkB proteins

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Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA

21 January 2018

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Reversal of DNA alkylation damage by two human dioxygenases

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DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation

21 January 2018

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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

21 January 2018

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Variation in FTO contributes to childhood obesity and severe adult obesity

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Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits

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Inactivation of the Fto gene protects from obesity

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Overexpression of Fto leads to increased food intake and results in obesity

21 January 2018

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The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

21 January 2018

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Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO

21 January 2018

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N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

21 January 2018

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ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility

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Repairing DNA-methylation damage

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Alkylation damage in DNA and RNA--repair mechanisms and medical significance

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Direct reversal of DNA alkylation damage

21 January 2018

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Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons

21 January 2018

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Reversible RNA adenosine methylation in biological regulation

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Sprouts of RNA epigenetics: the discovery of mammalian RNA demethylases.

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Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

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Crystal structure of the FTO protein reveals basis for its substrate specificity

21 January 2018

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Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage

21 January 2018

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Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB

21 January 2018

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Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA

21 January 2018

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Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase

21 January 2018

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Duplex interrogation by a direct DNA repair protein in search of base damage

21 January 2018

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Structural and Mutational Analysis of Escherichia coli AlkB Provides Insight into Substrate Specificity and DNA Damage Searching

21 January 2018

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Enzymological and structural studies of the mechanism of promiscuous substrate recognition by the oxidative DNA repair enzyme AlkB

21 January 2018

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AlkB dioxygenase preferentially repairs protonated substrates: specificity against exocyclic adducts and molecular mechanism of action

21 January 2018

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Exocyclic carbons adjacent to the N6 of adenine are targets for oxidation by the Escherichia coli adaptive response protein AlkB.

21 January 2018

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Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor

21 January 2018

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Structural basis for inhibition of the fat mass and obesity associated protein (FTO)

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ANIE.201310050

2 references

Consolidated OpenCitations Corpus – April 2017

1786668

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24596302%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1786668

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

1786668