Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights (Q27687877)

1

0 references

Anna Erdei

object named as

Anna Erdei

9

0 references

author name string

Mary Marfori

2

0 references

Máté Borsos

3

0 references

Ildikó Scheer

4

0 references

Enikő Takács

5

0 references

Judit Tóth

6

0 references

Fruzsina Babos

7

0 references

Anna Magyar

8

0 references

Zoltán Bozóky

10

0 references

László Buday

11

0 references

Beáta G Vértessy

Acta Crystallographica Section D: Biological Crystallography

13

0 references

language of work or name

English

0 references

publication date

December 2013

0 references

published in

0 references

volume

69

0 references

issue

Pt 12

0 references

page(s)

2495-505

0 references

cites work

PHENIX: a comprehensive Python-based system for macromolecular structure solution

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Developmental regulation of dUTPase in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Calpain-catalyzed proteolysis of human dUTPase specifically removes the nuclear localization signal peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

MolProbity: all-atom structure validation for macromolecular crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

From crystal to structure with CCP4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Coot: model-building tools for molecular graphics

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-α

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

CRM1 is an export receptor for leucine-rich nuclear export signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

House cleaning, a part of good housekeeping

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Clb6/Cdc28 and Cdc14 regulate phosphorylation status and cellular localization of Swi6

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Distinct functions for the two importin subunits in nuclear protein import

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Regulation of nuclear import by phosphorylation adjacent to nuclear localization signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Phosphorylation on protein kinase C sites inhibits nuclear import of lamin B2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Regulation of Cdh1-APC function in axon growth by Cdh1 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Phosphorylation of nuclear localization signal inhibits the ligand-dependent nuclear import of aryl hydrocarbon receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

p34cdc2-mediated phosphorylation at T124 inhibits nuclear import of SV-40 T antigen proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Cyclin-dependent kinase site-regulated signal-dependent nuclear localization of the SW15 yeast transcription factor in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Cell cycle-dependent nuclear export of Cdh1p may contribute to the inactivation of APC/C(Cdh1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Pse1/Kap121.

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

The human dUTPase gene encodes both nuclear and mitochondrial isoforms. Differential expression of the isoforms and characterization of a cDNA encoding the mitochondrial species

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Identification of a consensus cyclin-dependent kinase phosphorylation site unique to the nuclear form of human deoxyuridine triphosphate nucleotidohydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Characterization of distinct nuclear and mitochondrial forms of human deoxyuridine triphosphate nucleotidohydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Classical nuclear localization signals: definition, function, and interaction with importin alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Serine 312 phosphorylation is dispensable for wild-type p53 functions in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

CDK phosphorylation of a novel NLS-NES module distributed between two subunits of the Mcm2-7 complex prevents chromosomal rereplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Structural basis of high-affinity nuclear localization signal interactions with importin-α

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Molecular basis for specificity of nuclear import and prediction of nuclear localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Phasercrystallographic software

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Blu-Ice and the Distributed Control System: software for data acquisition and instrument control at macromolecular crystallography beamlines

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Cellular response to efficient dUTPase RNAi silencing in stable HeLa cell lines perturbs expression levels of genes involved in thymidylate metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Uracil-containing DNA in Drosophila: stability, stage-specific accumulation, and developmental involvement

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Nuclear localization signal-dependent and -independent movements of Drosophila melanogaster dUTPase isoforms during nuclear cleavage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Evolutionary and mechanistic insights into substrate and product accommodation of CTP:phosphocholine cytidylyltransferase from Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Phosphorylation meets nuclear import: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

The dUTPase enzyme is essential in Mycobacterium smegmatis

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Nucleotide pyrophosphatase employs a P-loop-like motif to enhance catalytic power and NDP/NTP discrimination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Regulation of nuclear transport: central role in development and transformation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Cell cycle-regulated phosphorylation of Swi6 controls its nuclear localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Identification of a region within the ubiquitin-activating enzyme required for nuclear targeting and phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

The cell cycle-dependent nuclear import of v-Jun is regulated by phosphorylation of a serine adjacent to the nuclear localization signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Molecular shape and prominent role of beta-strand swapping in organization of dUTPase oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

A tradeoff between protein stability and conformational mobility in homotrimeric dUTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

The chemical biology of protein phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Identification of sequence determinants of human nuclear dUTPase isoform localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Overview of the CCP4 suite and current developments

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Nuclear localization of the cell cycle regulator CDH1 and its regulation by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354

Recognition of Nucleoplasmin by Its Nuclear Transport Receptor Importin α/β: Insights into a Complete Import Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS0907444913023354