Precision is essential for efficient catalysis in an evolved Kemp eliminase (Q27687243)

2

0 references

author name string

Rebecca Blomberg

1

0 references

Peer R E Mittl

4

0 references

Markus G Grütter

5

0 references

Heidi K Privett

6

0 references

Stephen L Mayo

7

0 references

Donald Hilvert

Molecular Architecture and Biological Reactions

8

0 references

language of work or name

English

0 references

publication date

21 November 2013

0 references

published in

Nature

0 references

volume

503

0 references

page(s)

418-21

0 references

issue

7476

0 references

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Critical analysis of antibody catalysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Iterative approach to computational enzyme design

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Free-energy profile of the reaction catalyzed by triosephosphate isomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Triosephosphate isomerase catalysis is diffusion controlled. Appendix: Analysis of triose phosphate equilibria in aqueous solution by 31P NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Enzyme catalysis: not different, just better

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Triosephosphate isomerase: a highly evolved biocatalyst

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

A paradigm for enzyme-catalyzed proton transfer at carbon: triosephosphate isomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Large rate accelerations in antibody catalysis by strategic use of haptenic charge

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Kemp elimination catalysts by computational enzyme design

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Design of a switchable eliminase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Specificity and kinetics of triose phosphate isomerase from chicken muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Nonspecific medium effects versus specific group positioning in the antibody and albumin catalysis of the base-promoted ring-opening reactions of benzisoxazoles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Structural origins of efficient proton abstraction from carbon by a catalytic antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Site-directed mutagenesis and the role of the oxyanion hole in subtilisin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Exploring challenges in rational enzyme design by simulating the catalysis in artificial kemp eliminase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Evolution of enzyme function and the development of catalytic efficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Trading accuracy for speed: A quantitative comparison of search algorithms in protein sequence design

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Electrostatic basis for enzyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Experimental library screening demonstrates the successful application of computational protein design to large structural ensembles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Evaluation and ranking of enzyme designs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Computational enzyme design

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

De novo enzymes by computational design

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Combinatorial methods for small-molecule placement in computational enzyme design

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Addressing the numbers problem in directed evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Iterative saturation mutagenesis (ISM) for rapid directed evolution of functional enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

OligoCalc: an online oligonucleotide properties calculator.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Reducing codon redundancy and screening effort of combinatorial protein libraries created by saturation mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Probing the role of the C-terminus of Bacillus subtilis chorismate mutase by a novel random protein-termination strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Phasercrystallographic software

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

PHENIX: a comprehensive Python-based system for macromolecular structure solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Coot: model-building tools for molecular graphics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

CAVER 3.0: a tool for the analysis of transport pathways in dynamic protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Close agreement between the orientation dependence of hydrogen bonds observed in protein structures and quantum mechanical calculations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12623

Enzyme catalysis: conflicting requirements of substrate access and transition state affinity.

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24132235

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Toward bifunctional antibody catalysis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24132235