Virtual screening and structure-based discovery of indole acylguanidines as potent β-secretase (BACE1) inhibitors (Q27684634)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23681056%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

Virtual screening and structure-based discovery of indole acylguanidines as potent β-secretase (BACE1) inhibitors (English)

1 reference

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1 March 2020

1 reference

Yiquan Zou

1

1 reference

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1 March 2020

Li Li

2

1 reference

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1 March 2020

Wuyan Chen

3

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1 March 2020

Tiantian Chen

4

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1 March 2020

Lanping Ma

5

1 reference

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1 March 2020

Xin Wang

6

1 reference

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1 March 2020

Bing Xiong

7

1 reference

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1 March 2020

Yechun Xu

8

1 reference

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1 March 2020

Jingkang Shen

9

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1 March 2020

language of work or name

English

0 references

publication date

16 May 2013

1 reference

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1 March 2020

1 reference

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1 March 2020

volume

18

1 reference

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1 March 2020

issue

5

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1 March 2020

page(s)

5706-5722

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Creative Commons Attribution 4.0 International

1 March 2020

copyright license

start time

16 May 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

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BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time

21 January 2018

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Control of peripheral nerve myelination by the beta-secretase BACE1

21 January 2018

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BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus

21 January 2018

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Design and Synthesis of Statine-Based Cell-Permeable Peptidomimetic Inhibitors of Human β-Secretase

21 January 2018

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Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

21 January 2018

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Design and synthesis of 2,3,5-substituted imidazolidin-4-one inhibitors of BACE-1

21 January 2018

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Second generation of hydroxyethylamine BACE-1 inhibitors: optimizing potency and oral bioavailability

21 January 2018

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Design and synthesis of hydroxyethylene-based peptidomimetic inhibitors of human beta-secretase

21 January 2018

1 reference

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Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics

21 January 2018

1 reference

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Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: exploration of P1 phenoxy and benzyloxy residues

21 January 2018

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Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood-brain barrier penetration

21 January 2018

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Blood-brain barrier delivery

21 January 2018

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Fragment-based discovery of BACE1 inhibitors using functional assays

21 January 2018

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Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase

21 January 2018

1 reference

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Discovery of a novel warhead against beta-secretase through fragment-based lead generation

21 January 2018

1 reference

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Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors

21 January 2018

1 reference

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Fragment-based lead discovery grows up.

21 January 2018

1 reference

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Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

21 January 2018

1 reference

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Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18055706

Acyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis

21 January 2018

1 reference

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Optimization of 1,3,4-benzotriazepine-based CCK(2) antagonists to obtain potent, orally active inhibitors of gastrin-mediated gastric acid secretion

21 January 2018

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Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981.

21 January 2018

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Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1.

21 January 2018

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Synthesis of (+/-)-bistellettadine A.

21 January 2018

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NG-Acyl-argininamides as NPY Y1 receptor antagonists: Influence of structurally diverse acyl substituents on stability and affinity

21 January 2018

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Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations

21 January 2018

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21 January 2018

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The CCP4 suite: programs for protein crystallography

21 January 2018

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PHENIX: building new software for automated crystallographic structure determination

21 January 2018

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Coot: model-building tools for molecular graphics

21 January 2018

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Design and synthesis of statine-containing BACE inhibitors

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23681056

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Progress toward the discovery and development of efficacious BACE inhibitors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23681056

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Acylguanidines as small-molecule beta-secretase inhibitors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23681056

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3390/MOLECULES18055706

2 references

Consolidated OpenCitations Corpus – April 2017

2394511

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23681056%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

2394511

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23681056%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

PubMed publication ID

23681056

2 references

Consolidated OpenCitations Corpus – April 2017

2394511