R -Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi (Q27684247)

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Claudia M Calvet

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Debora F Vieira

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Shamila S Gunatilleke

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Michael D Cameron

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Larissa M Podust

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William R Roush

ACS Medicinal Chemistry Letters

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publication date

10 April 2014

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published in

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Rational Development of 4-Aminopyridyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51 as Anti-Chagas Agents

Crossref

volume

5

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page(s)

434-9

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issue

4

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cites work

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VNI cures acute and chronic experimental Chagas disease

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Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole

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Trypanosoma cruzi CYP51 Inhibitor Derived from a Mycobacterium tuberculosis Screen Hit

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Induction of resistance to azole drugs in Trypanosoma cruzi

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Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens

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Fast, easy, clean chemistry by using water as a solvent and microwave heating: the Suzuki coupling as an illustration

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Scope and limitations of the Pd/BINAP-catalyzed amination of aryl bromides

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Identifiers

DOI

10.1021/ML500010M

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5106243

5106243

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