Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysis (Q27681754)

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7 February 2020

title

Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysis (English)

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7 February 2020

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0 references

1

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7 February 2020

3

Lawrence J Marnett

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7 February 2020

author name string

Timothy C Mueser

series ordinal

2

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7 February 2020

Max O Funk

series ordinal

4

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language of work or name

English

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publication date

12 July 2012

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7 February 2020

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7 February 2020

volume

20

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7 February 2020

page(s)

1490-1497

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7 February 2020

issue

9

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iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM

7 February 2020

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20 March 2017

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Functional and pathological roles of the 12- and 15-lipoxygenases

20 March 2017

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20 March 2017

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The 1.85 Å Structure of an 8 R -Lipoxygenase Suggests a General Model for Lipoxygenase Product Specificity

20 March 2017

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20 March 2017

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Conformational flexibility in mammalian 15S-lipoxygenase: Reinterpretation of the crystallographic data

20 March 2017

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20 March 2017

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20 March 2017

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Interaction between non-heme iron of lipoxygenases and cumene hydroperoxide: basis for enzyme activation, inactivation, and inhibition

20 March 2017

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20 March 2017

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Prostaglandins and leukotrienes: advances in eicosanoid biology

20 March 2017

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The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity

20 March 2017

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Structure of soybean lipoxygenase L3 and a comparison with its L1 isoenzyme

20 March 2017

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Crystal structure of soybean lipoxygenase L-1 at 1.4 A resolution

20 March 2017

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Cloning of the cDNA for human 5-lipoxygenase

20 March 2017

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Molecular cloning and primary structure of human 15-lipoxygenase

20 March 2017

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Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase

20 March 2017

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Identification of new, well-populated amino-acid sidechain rotamers involving hydroxyl-hydrogen atoms and sulfhydryl-hydrogen atoms

20 March 2017

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Molecular enzymology of lipoxygenases

7 April 2017

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EPR spectroscopy and electrospray ionization mass spectrometry reveal distinctive features of the iron site in leukocyte 12-lipoxygenase.

29 September 2017

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Molecular dioxygen enters the active site of 12/15-lipoxygenase via dynamic oxygen access channels

29 September 2017

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Tunneling and dynamics in enzymatic hydride transfer

29 September 2017

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A single active site residue directs oxygenation stereospecificity in lipoxygenases: stereocontrol is linked to the position of oxygenation

29 September 2017

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The N-terminal domain of the reticulocyte-type 15-lipoxygenase is not essential for enzymatic activity but contains determinants for membrane binding

29 September 2017

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Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate

29 September 2017

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Lipoxygenases: structural principles and spectroscopy

29 September 2017

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Expression of porcine leukocyte 12-lipoxygenase in a baculovirus/insect cell system and its characterization

29 September 2017

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Probing Dimerization and Structural Flexibility of Mammalian Lipoxygenases by Small-Angle X-ray Scattering

2 June 2018

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Insights into the mechanism of binding of arachidonic acid to mammalian 15-lipoxygenases.

27 November 2018

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Direct incorporation of experimental phase information in model refinement.

27 November 2018

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Kinetics of inhibition of leukocyte 12-lipoxygenase by the isoform-specific inhibitor 4-(2-oxapentadeca-4-yne)phenylpropanoic acid

27 November 2018

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Leukocyte 12-lipoxygenase: expression, purification, and investigation of the role of methionine residues in turnover-dependent inactivation and 5,8,11,14-eicosatetraynoic acid inhibition.

27 November 2018

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Expression, purification, and characterization of porcine leukocyte 12-lipoxygenase produced in the methylotrophic yeast, Pichia pastoris.

27 November 2018

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(Carboxyalkyl)benzyl propargyl ethers as selective inhibitors of leukocyte-type 12-lipoxygenases

27 November 2018

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12 December 2020

C-H...pi-interactions in proteins

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12 December 2020

Arachidonate 12-lipoxygenase purified from porcine leukocytes by immunoaffinity chromatography and its reactivity with hydroperoxyeicosatetraenoic acids

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12 December 2020

HOLLOW: generating accurate representations of channel and interior surfaces in molecular structures

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12 December 2020

The promoter structure and complete sequence of the gene encoding the rabbit erythroid cell-specific 15-lipoxygenase

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12 December 2020

Mechanism of inhibition of porcine leukocyte 12-lipoxygenase by the isoform-specific inhibitor 4-(2-oxapentadeca-4-yne)phenylpropanoic acid

1 reference

12 December 2020

10.1016/J.STR.2012.06.003

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7 February 2020

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7 February 2020

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