Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli (Q27681431)

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6 March 2020

title

Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli (English)

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6 March 2020

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0 references

10

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6 March 2020

Christoph Klenk

3

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6 March 2020

Alexander Batyuk

4

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6 March 2020

Philipp Heine

5

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6 March 2020

Daniel J. Scott

8

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6 March 2020

author name string

Pascal Egloff

1

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6 March 2020

Matthias Hillenbrand

2

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6 March 2020

Stefanie Balada

6

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6 March 2020

Karola M Schlinkmann

7

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6 March 2020

Marco Schütz

9

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6 March 2020

language of work or name

English

0 references

publication date

22 January 2014

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

6 March 2020

published in

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6 March 2020

volume

111

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6 March 2020

page(s)

E655-62

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6 March 2020

issue

6

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High-resolution crystal structure of human protease-activated receptor 1

6 March 2020

cites work

1 reference

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Structure of the agonist-bound neurotensin receptor

20 March 2017

1 reference

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Membrane-sensitive conformational states of helix 8 in the metabotropic Glu2 receptor, a class C GPCR

20 March 2017

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Crystal structure of the β2 adrenergic receptor-Gs protein complex

20 March 2017

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Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains

20 March 2017

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Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

20 March 2017

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Crystal structure of metarhodopsin II

20 March 2017

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The structural basis of agonist-induced activation in constitutively active rhodopsin

20 March 2017

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Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists

20 March 2017

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Crystal structure of opsin in its G-protein-interacting conformation

20 March 2017

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Structure of a beta1-adrenergic G-protein-coupled receptor

20 March 2017

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Crystal structure of the ligand-free G-protein-coupled receptor opsin

20 March 2017

1 reference

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Mitosis and inhibition of intracellular transport stimulate palmitoylation of a 62-kD protein

20 March 2017

1 reference

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Shape complementarity at protein/protein interfaces

20 March 2017

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Selective interactions between helix VIII of the human mu-opioid receptors and the C terminus of periplakin disrupt G protein activation

20 March 2017

1 reference

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Directed evolution of a G protein-coupled receptor for expression, stability, and binding selectivity

20 March 2017

1 reference

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Increased plasma neurotensin concentrations in patients with Parkinson's disease

20 March 2017

1 reference

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Molecular cloning of a levocabastine-sensitive neurotensin binding site

20 March 2017

1 reference

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Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling

20 March 2017

1 reference

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Direct molecular evolution of detergent-stable G protein-coupled receptors using polymer encapsulated cells

9 May 2017

1 reference

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Maximizing detergent stability and functional expression of a GPCR by exhaustive recombination and evolution

29 September 2017

1 reference

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Critical features for biosynthesis, stability, and functionality of a G protein-coupled receptor uncovered by all-versus-all mutations

29 September 2017

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Neuropeptide receptor ligands as drugs for psychiatric diseases: the end of the beginning?

29 September 2017

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Conformational dynamics of helix 8 in the GPCR rhodopsin controls arrestin activation in the desensitization process.

29 September 2017

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Activation and molecular recognition of the GPCR rhodopsin--insights from time-resolved fluorescence depolarisation and single molecule experiments

29 September 2017

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Structural insights into agonist-induced activation of G-protein-coupled receptors

29 September 2017

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Neurotensin receptor 1 determines the outcome of non-small cell lung cancer

29 September 2017

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Role of helix 8 in G protein-coupled receptors based on structure-function studies on the type 1 angiotensin receptor

29 September 2017

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G-protein-coupled receptors, cholesterol and palmitoylation: facts about fats

29 September 2017

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Crystal packing analysis of Rhodopsin crystals

29 September 2017

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Functional domains of the subtype 1 neurotensin receptor (NTS1).

29 September 2017

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Characterization of the residues in helix 8 of the human beta1-adrenergic receptor that are involved in coupling the receptor to G proteins

29 September 2017

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Cell-type-specific pathways of neurotensin endocytosis

29 September 2017

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The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B(1) and B(2) bradykinin receptors.

29 September 2017

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Receptor trafficking via the perinuclear recycling compartment accompanied by cell division is necessary for permanent neurotensin cell sensitization and leads to chronic mitogen-activated protein kinase activation

29 September 2017

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Role of palmitoylation/depalmitoylation reactions in G-protein-coupled receptor function

29 September 2017

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X-Ray diffraction analysis of three-dimensional crystals of bovine rhodopsin obtained from mixed micelles.

29 September 2017

1 reference

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Analysis and refinement of criteria for predicting the structure and relative orientations of transmembranal helical domains

29 September 2017

1 reference

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Hypothermia and intolerance to cold induced by intracisternal administration of the hypothalamic peptide neurotensin

29 September 2017

1 reference

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Neurotensin agonist induces differential regulation of neurotensin receptor mRNA. Identification of distinct transcriptional and post-transcriptional mechanisms.

29 September 2017

1 reference

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Purification of a rat neurotensin receptor expressed in Escherichia coli

2 June 2018

1 reference

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Structure and functional expression of the cloned rat neurotensin receptor

2 June 2018

1 reference

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Differential involvement of intracellular domains of the rat NTS1 neurotensin receptor in coupling to G proteins: a molecular basis for agonist-directed trafficking of receptor stimulus.

2 June 2018

1 reference

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Evolution of three human GPCRs for higher expression and stability.

21 January 2018

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Identification in the rat neurotensin receptor of amino-acid residues critical for the binding of neurotensin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1317903111

Residues in the hydrophilic face of putative helix 8 of oxytocin receptor are important for receptor function

21 January 2018

1 reference

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Automated large-scale purification of a G protein-coupled receptor for neurotensin

21 January 2018

1 reference

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Large-scale expression and purification of a G-protein-coupled receptor for structure determination -- an overview

21 January 2018

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Identification of residues involved in neurotensin binding and modeling of the agonist binding site in neurotensin receptor 1

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24453215

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1317903111

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24453215%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

ADS bibcode

2014PNAS..111E.655E

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24453215%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24453215%20AND%20SRC:MED&resulttype=core&format=json