The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol (Q27679405)

2

Yuanli

Song

1 reference

20 October 2023

Wade D Van Horn

3

Wade D

Van Horn

1 reference

20 October 2023

Eric J Hustedt

4

Eric J

Hustedt

1 reference

20 October 2023

Johanna M Schafer

5

Johanna M

Schafer

1 reference

20 October 2023

Arina Hadziselimovic

6

Arina

Hadziselimovic

1 reference

20 October 2023

Andrew J Beel

7

Andrew J

Beel

1 reference

20 October 2023

Charles R Sanders

8

Charles R

Structural and dynamic study of the transmembrane domain of the amyloid precursor protein

Sanders

1 reference

20 October 2023

language of work or name

English

0 references

publication date

1 June 2012

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published in

Science

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volume

336

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issue

6085

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page(s)

1168-71

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cites work

1 reference

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Membrane lipids: where they are and how they behave

20 March 2017

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Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

20 March 2017

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A transmembrane helix dimer: structure and implications

20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

20 March 2017

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Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices

20 March 2017

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Utilization of site-directed spin labeling and high-resolution heteronuclear nuclear magnetic resonance for global fold determination of large proteins with limited nuclear overhauser effect data

20 March 2017

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Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein

7 April 2017

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Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane re

29 September 2017

1 reference

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Amyloid precursor protein processing and Alzheimer's disease

29 September 2017

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Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy

29 September 2017

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Evidence from solid-state NMR for nonhelical conformations in the transmembrane domain of the amyloid precursor protein

29 September 2017

1 reference

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Taking the plunge: integrating structural, enzymatic and computational insights into a unified model for membrane-immersed rhomboid proteolysis

29 September 2017

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Structures of beta-amyloid peptide 1-40, 1-42, and 1-55-the 672-726 fragment of APP-in a membrane environment with implications for interactions with gamma-secretase

29 September 2017

1 reference

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Cholesterol and statins in Alzheimer's disease: current controversies

29 September 2017

1 reference

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Intramembrane proteolysis

29 September 2017

1 reference

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A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis

29 September 2017

1 reference

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Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution

29 September 2017

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Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor?

29 September 2017

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Substrate-targeting gamma-secretase modulators

29 September 2017

1 reference

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Proteins and cholesterol-rich domains

29 September 2017

1 reference

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Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin

29 September 2017

1 reference

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Top-down approach in protein RDC data analysis: de novo estimation of the alignment tensor.

29 September 2017

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GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.

29 September 2017

1 reference

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Transmembrane glycine zippers: physiological and pathological roles in membrane proteins

29 September 2017

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Cholesterol and amyloid beta fibrillogenesis

29 September 2017

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Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

29 September 2017

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Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

29 September 2017

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Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

29 September 2017

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A collision gradient method to determine the immersion depth of nitroxides in lipid bilayers: application to spin-labeled mutants of bacteriorhodopsin

29 September 2017

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Chemical shifts as a tool for structure determination

29 September 2017

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Direct and potent regulation of gamma-secretase by its lipid microenvironment

29 September 2017

1 reference

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Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528355

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528355

DEER distance measurements on proteins

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528355

The amyloid precursor protein C-terminal fragment C100 occurs in monomeric and dimeric stable conformations and binds γ-secretase modulators

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528355

gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528355

A detergent-insoluble membrane compartment contains A beta in vivo.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528355

27 November 2018

Identifiers

DOI

10.1126/SCIENCE.1219988

1 reference

2143650

ADS bibcode

2012Sci...336.1168B

0 references

2143650

1 reference

1 reference

1 reference