Discovery of Protein–Protein Interaction Inhibitors of Replication Protein A (Q27679367)

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6 March 2020

title

Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A (English)

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6 March 2020

0 references

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protein-protein interaction

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3

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6 March 2020

10

Stephen W Fesik

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6 March 2020

author name string

James D Patrone

1

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6 March 2020

J Phillip Kennedy

2

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6 March 2020

Michael D Feldkamp

4

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6 March 2020

Bhavatarini Vangamudi

5

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6 March 2020

Nicholas F Pelz

6

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6 March 2020

Olivia W Rossanese

7

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6 March 2020

Alex G Waterson

8

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6 March 2020

Walter J Chazin

9

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6 March 2020

publication date

1 July 2013

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ACS Medicinal Chemistry Letters

6 March 2020

published in

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Crossref

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6 March 2020

volume

4

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6 March 2020

page(s)

601-605

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issue

7

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ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation

6 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728914

Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728914

Functional and physical interaction between WRN helicase and human replication protein A

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728914

Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism

20 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728914

20 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728914

A small molecule directly inhibits the p53 transactivation domain from binding to replication protein A.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728914

A high-throughput fluorescence polarization anisotropy assay for the 70N domain of replication protein A.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728914

Small molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728914

Targeted inhibition of Replication Protein A reveals cytotoxic activity, synergy with chemotherapeutic DNA-damaging agents, and insight into cellular function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728914

The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728914

Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728914

Development of a high-throughput screen for inhibitors of replication protein A and its role in nucleotide excision repair.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728914

Role of protein-protein interactions in the function of replication protein A (RPA): RPA modulates the activity of DNA polymerase alpha by multiple mechanisms

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728914

Interactions of human replication protein A with oligonucleotides

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728914

Purification and characterization of replication protein A, a cellular protein required for in vitro replication of simian virus 40 DNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728914

Synthesis, characterization and biological activities of some new benzo[b]thiophene derivatives

29 September 2017

1 reference

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Discovery of a new series of potent and selective linear tachykinin NK2 receptor antagonists

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728914

5' --> 3' molecular polarity of human replication protein A (hRPA) binding to pseudo-origin DNA substrates

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23914285

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ML400032Y

1 reference

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6 March 2020

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6 March 2020

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