Divergence of multimodular polyketide synthases revealed by a didomain structure (Q27679312)

1

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Darren C Gay

2

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Mark A White

4

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Adrian T Keatinge-Clay

Structural and functional analysis of C2-type ketoreductases from modular polyketide synthases

5

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language of work or name

1 reference

July 2012

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published in

Nature Chemical Biology

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volume

8

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issue

7

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page(s)

615-21

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cites work

1 reference

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20 March 2017

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Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase

20 March 2017

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Crystal Structures of Dehydratase Domains from the Curacin Polyketide Biosynthetic Pathway

20 March 2017

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20 March 2017

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Medium- and short-chain dehydrogenase/reductase gene and protein families : the MDR superfamily

20 March 2017

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Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase

20 March 2017

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The crystal structure of a mammalian fatty acid synthase

20 March 2017

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Structural enzymological studies of 2-enoyl thioester reductase of the human mitochondrial FAS II pathway: new insights into its substrate recognition properties

20 March 2017

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Solution structure and proposed domain-domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase

20 March 2017

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A tylosin ketoreductase reveals how chirality is determined in polyketides

20 March 2017

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Candida tropicalis expresses two mitochondrial 2-enoyl thioester reductases that are able to form both homodimers and heterodimers

20 March 2017

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Structure-function analysis of enoyl thioester reductase involved in mitochondrial maintenance

20 March 2017

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3D domain swapping: as domains continue to swap

20 March 2017

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Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel

20 March 2017

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The SH3 domain of Eps8 exists as a novel intertwined dimer

20 March 2017

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Crystal structure of Escherichia coli QOR quinone oxidoreductase complexed with NADPH

20 March 2017

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Dali server: conservation mapping in 3D

20 March 2017

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Coot: model-building tools for molecular graphics

20 March 2017

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A graphical user interface to the CCP4 program suite

20 March 2017

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Mechanism and inhibition of the FabV enoyl-ACP reductase from Burkholderia mallei

20 March 2017

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X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution

20 March 2017

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CRYSOL– a Program to Evaluate X-ray Solution Scattering of Biological Macromolecules from Atomic Coordinates

7 April 2017

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Experimental mapping of soluble protein domains using a hierarchical approach

22 April 2017

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Mutagenesis of a modular polyketide synthase enoylreductase domain reveals insights into catalysis and stereospecificity

29 September 2017

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The spinosyn family of insecticides: realizing the potential of natural products research

29 September 2017

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The biochemical basis for stereochemical control in polyketide biosynthesis

29 September 2017

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The type I fatty acid and polyketide synthases: a tale of two megasynthases

29 September 2017

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Structure and mechanism of the 6-deoxyerythronolide B synthase

29 September 2017

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The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.

29 September 2017

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Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain

29 September 2017

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Short-chain dehydrogenases/reductases (SDR): the 2002 update

29 September 2017

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Evidence for a double-helical structure for modular polyketide synthases.

29 September 2017

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The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases.

29 September 2017

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Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases

21 January 2018

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DAMMIF, a program for rapid ab-initio shape determination in small-angle scattering

21 January 2018

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Sedimentation velocity analysis of highly heterogeneous systems.

21 January 2018

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Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.964

Characterization of the beta-carbon processing reactions of the mammalian cytosolic fatty acid synthase: role of the central core

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.964

Automated matching of high- and low-resolution structural models

21 January 2018

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Molecular Basis of Celmer's Rules: Stereochemistry of Catalysis by Isolated Ketoreductase Domains from Modular Polyketide Synthases

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22634636

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Employing modular polyketide synthase ketoreductases as biocatalysts in the preparative chemoenzymatic syntheses of diketide chiral building blocks

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22634636

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Processing of X-ray diffraction data collected in oscillation mode

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22634636

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.964

1 reference

Dimensions Publication ID

4773293

1053513340

0 references

4773293

1 reference

1 reference

1 reference