Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids (Q27679226)

12

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Marianne de Villiers

object named as

Marianne de Villiers

7

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Frank J Dekker

object named as

Frank J Dekker

8

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author name string

Hans Raj

1

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Wiktor Szymański

2

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Jandré de Villiers

3

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Henriëtte J Rozeboom

4

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Vinod Puthan Veetil

5

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Carlos R Reis

6

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Stefaan de Wildeman

9

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Wim J Quax

10

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Andy-Mark W H Thunnissen

11

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Dick B Janssen

13

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Gerrit J Poelarends

Biocatalysis--key to sustainable industrial chemistry

14

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publication date

29 April 2012

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published in

Nature Chemistry

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volume

4

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issue

6

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page(s)

478-84

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cites work

1 reference

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Advances in biocatalytic synthesis of pharmaceutical intermediates

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Trends and innovations in industrial biocatalysis for the production of fine chemicals.

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Ammonia lyases and aminomutases as biocatalysts for the synthesis of α-amino and β-amino acids

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Cloning, sequencing, and expression in Escherichia coli of the Clostridium tetanomorphum gene encoding beta-methylaspartase and characterization of the recombinant protein

21 January 2018

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Alteration of the diastereoselectivity of 3-methylaspartate ammonia lyase by using structure-based mutagenesis

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The structure of 3-methylaspartase from Clostridium tetanomorphum functions via the common enolase chemical step

21 January 2018

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Insights into enzyme evolution revealed by the structure of methylaspartate ammonia lyase

21 January 2018

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The enolase superfamily: a general strategy for enzyme-catalyzed abstraction of the alpha-protons of carboxylic acids

21 January 2018

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Improving enzyme properties: when are closer mutations better?

21 January 2018

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Directed evolution drives the next generation of biocatalysts

21 January 2018

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Characterization of novel L-threo-beta-benzyloxyaspartate derivatives, potent blockers of the glutamate transporters

21 January 2018

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Glutamate transporter blockers for elucidation of the function of excitatory neurotransmission systems

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The substituted aspartate analogue L-beta-threo-benzyl-aspartate preferentially inhibits the neuronal excitatory amino acid transporter EAAT3.

21 January 2018

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The excitatory amino acid transporters: pharmacological insights on substrate and inhibitor specificity of the EAAT subtypes

21 January 2018

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Synthesis and preliminary pharmacological evaluation of novel derivatives of L-beta-threo-benzylaspartate as inhibitors of the neuronal glutamate transporter EAAT3

21 January 2018

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Syntheses of optically pure beta-hydroxyaspartate derivatives as glutamate transporter blockers

21 January 2018

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Synthesis of orthogonally protected L-threo-beta-ethoxyasparagine

21 January 2018

1 reference

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Design of synthetic gene libraries encoding random sequence proteins with desired ensemble characteristics

21 January 2018

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Site-directed mutagenesis by overlap extension using the polymerase chain reaction

21 January 2018

1 reference

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THE MECHANISM OF THE METHYLASPARTATE AMMONIA-LYASE REACTION: DEUTERIUM EXCHANGE

21 January 2018

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12 December 2020

The purification and properties of beta-methylaspartase

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12 December 2020

Expanding the range of substrate acceptance of enzymes: combinatorial active-site saturation test

1 reference

12 December 2020

THE MECHANISM OF THE BETA-METHYLASPARTASE REACTION

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12 December 2020

Substrate specificity of the 3-methylaspartate ammonia-lyase reaction: observation of differential relative reaction rates for substrate-product pairs

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12 December 2020

3-Methylaspartate ammonia-lyase as a marker enzyme of the mesaconate pathway for (S)-glutamate fermentation in Enterobacteriaceae

1 reference

12 December 2020

ON THE MECHANISM OF DIVALENT METAL ACTIVATION OF BETA-METHYLASPARTASE

1 reference

12 December 2020

Divalent Metal Activation of β-Methylaspartase. The Importance of Ionic Radius*

1 reference

12 December 2020

Dimensions Publication ID

Identifiers

DOI

10.1038/NCHEM.1338

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1014834623

0 references

Fatcat ID

release_lziairul2nfh3od7eggmq2y4ae

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/lziairul2nfh3od7eggmq2y4ae

24 November 2022