3′-Processing and strand transfer catalysed by retroviral integrasein crystallo (Q27679066)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22580823%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

3'-processing and strand transfer catalysed by retroviral integrase in crystallo (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22580823%20AND%20SRC:MED&resulttype=core&format=json

catalytic activity, acting on DNA

1 February 2020

main subject

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0044825

retroviral 3' processing activity

1 reference

Gene Ontology release 2020-05-02

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22580823%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Goedele Maertens

series ordinal

2

1 reference

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1 February 2020

3

Peter Cherepanov

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22580823%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

language of work or name

English

0 references

publication date

11 May 2012

1 reference

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1 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22580823%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

volume

31

1 reference

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1 February 2020

page(s)

3020-3028

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22580823%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

issue

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22580823%20AND%20SRC:MED&resulttype=core&format=json

Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)

1 February 2020

cites work

1 reference

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The mechanism of retroviral integration from X-ray structures of its key intermediates

20 March 2017

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Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.

20 March 2017

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Retroviral intasome assembly and inhibition of DNA strand transfer

20 March 2017

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Functional and structural characterization of the integrase from the prototype foamy virus

20 March 2017

1 reference

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MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

20 March 2017

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Structure and mechanism of T4 polynucleotide kinase: an RNA repair enzyme

20 March 2017

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Three-dimensional structure of the Tn5 synaptic complex transposition intermediate

20 March 2017

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Structural principles for the inhibition of the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates

20 March 2017

1 reference

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Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases

20 March 2017

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20 March 2017

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Automated structure solution with the PHENIX suite

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395085

Scaling and assessment of data quality

20 March 2017

1 reference

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Coot: model-building tools for molecular graphics

20 March 2017

1 reference

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395085

Small revisions to predicted distances around metal sites in proteins

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395085

Making and breaking nucleic acids: two-Mg2+-ion catalysis and substrate specificity

7 April 2017

1 reference

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Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395085

Dolutegravir (S/GSK1349572) exhibits significantly slower dissociation than raltegravir and elvitegravir from wild-type and integrase inhibitor-resistant HIV-1 integrase-DNA complexes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395085

Retroviral integrases promote fraying of viral DNA ends

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395085

Catalytic mechanism of RNA backbone cleavage by ribonuclease H from quantum mechanics/molecular mechanics simulations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395085

Structural insights into the retroviral DNA integration apparatus.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395085

Biochemical and pharmacological analyses of HIV-1 integrase flexible loop mutants resistant to raltegravir

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395085

Strand transfer inhibitors of HIV-1 integrase: bringing IN a new era of antiretroviral therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395085

HIV-1 IN inhibitors: 2010 update and perspectives

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395085

Comparison of metal-dependent catalysis by HIV-1 and ASV integrase proteins using a new and rapid, moderate throughput assay for joining activity in solution

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395085

Characterization of a thermostable archaeal polynucleotide kinase homologous to human Clp1.

29 September 2017

1 reference

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Nucleoprotein complex intermediates in HIV-1 integration

29 September 2017

1 reference

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Phosphodiester cleavage in ribonuclease H occurs via an associative two-metal-aided catalytic mechanism.

29 September 2017

1 reference

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Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release

29 September 2017

1 reference

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Retroviral DNA integration: reaction pathway and critical intermediates

29 September 2017

1 reference

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Retroviral DNA integration--mechanism and consequences

29 September 2017

1 reference

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29 September 2017

Foamy virus integration

1 reference

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HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase

29 September 2017

1 reference

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Characterization of recombinant murine leukemia virus integrase.

29 September 2017

1 reference

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Efficient magnesium-dependent human immunodeficiency virus type 1 integrase activity

29 September 2017

1 reference

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Activities of human immunodeficiency virus (HIV) integration protein in vitro: specific cleavage and integration of HIV DNA

29 September 2017

1 reference

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Site-specific hydrolysis and alcoholysis of human immunodeficiency virus DNa termini mediated by the viral integrase protein

29 September 2017

1 reference

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Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro

29 September 2017

1 reference

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Residues critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395085

Stereospecificity of reactions catalyzed by HIV-1 integrase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395085

Inversion of the phosphate chirality at the target site of Mu DNA strand transfer: Evidence for a one-step transesterification mechanism

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395085

Disruption of the terminal base pairs of retroviral DNA during integration

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.118

Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.118

Single active site catalysis of the successive phosphoryl transfer steps by DNA transposases: insights from phosphorothioate stereoselectivity

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22580823

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22580823

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/EMBOJ.2012.118

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22580823%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22580823%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22580823%20AND%20SRC:MED&resulttype=core&format=json