Crystal structure of the high-affinity Na+,K+-ATPase-ouabain complex with Mg2+ bound in the cation binding site (Q27678678)

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3 March 2020

title

Crystal structure of the high-affinity Na+K+-ATPase-ouabain complex with Mg2+ bound in the cation binding site (English)

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3 March 2020

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3

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3 March 2020

Mette Laursen

1

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3 March 2020

Laure Yatime

2

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3 March 2020

Natalya Fedosova

4

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3 March 2020

author name string

Mette Laursen

1

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language of work or name

English

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publication date

17 June 2013

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Proceedings of the National Academy of Sciences of the United States of America

3 March 2020

published in

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3 March 2020

volume

110

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3 March 2020

page(s)

10958-10963

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3 March 2020

issue

27

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Structural insights into the high affinity binding of cardiotonic steroids to the Na+,K+-ATPase

3 March 2020

cites work

1 reference

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Crystal structure of the sodium-potassium pump (Na+,K+-ATPase) with bound potassium and ouabain

20 March 2017

1 reference

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Crystal structure of the sodium-potassium pump at 2.4 A resolution

20 March 2017

1 reference

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Crystal structure of the sodium–potassium pump

20 March 2017

1 reference

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The structural basis of calcium transport by the calcium pump

20 March 2017

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MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

20 March 2017

1 reference

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20 March 2017

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Toward the structural genomics of complexes: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis

20 March 2017

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Likelihood-enhanced fast translation functions

20 March 2017

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Coot: model-building tools for molecular graphics

20 March 2017

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The CCP4 suite: programs for protein crystallography

20 March 2017

1 reference

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PHENIX: building new software for automated crystallographic structure determination

20 March 2017

2 references

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20 March 2017

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The influence of some cations on an adenosine triphosphatase from peripheral nerves

22 April 2017

1 reference

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Biology, structure and mechanism of P-type ATPases

20 March 2017

1 reference

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Structural organization, ion transport, and energy transduction of P-type ATPases

20 March 2017

1 reference

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Stabilization of the α2 isoform of Na,K-ATPase by mutations in a phospholipid binding pocket

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704003

Ouabain binding site in a functioning Na+/K+ ATPase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704003

Selectivity of digitalis glycosides for isoforms of human Na,K-ATPase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704003

Signaling mechanisms that link salt retention to hypertension: endogenous ouabain, the Na(+) pump, the Na(+)/Ca(2+) exchanger and TRPC proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704003

Endogenous and exogenous cardiac glycosides and their mechanisms of action

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704003

Extensive random mutagenesis analysis of the Na+/K+-ATPase alpha subunit identifies known and previously unidentified amino acid residues that alter ouabain sensitivity--implications for ouabain binding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704003

Phosphorylation by inorganic phosphate of sodium plus potassium ion transport adenosine triphosphatase. Four reactive states

29 September 2017

1 reference

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Allosteric regulation of the access channels to the Rb+ occlusion sites of (Na+ + K+)-ATPase.

29 September 2017

1 reference

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Structure-function relationships in the Na,K-ATPase alpha subunit: site-directed mutagenesis of glutamine-111 to arginine and asparagine-122 to aspartic acid generates a ouabain-resistant enzyme

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704003

A hundred years of sodium pumping

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1222308110

Phe783, Thr797, and Asp804 in transmembrane hairpin M5-M6 of Na+,K+-ATPase play a key role in ouabain binding.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1222308110

Large-scale preparation of sodium-potassium ATPase from kidney outer medulla

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1222308110

Activation by adenosine triphosphate in the phosphorylation kinetics of sodium and potassium ion transport adenosine triphosphatase

21 January 2018

1 reference

12 December 2020

Reconstruction of the complete ouabain-binding pocket of Na,K-ATPase in gastric H,K-ATPase by substitution of only seven amino acids

1 reference

12 December 2020

Analysis of amino acid residues in the H5-H6 transmembrane and extracellular domains of Na,K-ATPase alpha subunit identifies threonine 797 as a determinant of ouabain sensitivity

1 reference

12 December 2020

E2P Phosphoforms of Na,K-ATPase. I. Comparison of Phosphointermediates Formed from ATP and Piby Their Reactivity toward Hydroxylamine and Vanadate†

1 reference

12 December 2020

Binding of sodium ions and cardiotonic steroids to native and selectively trypsinized Na,K pump, detected by charge movements

1 reference

12 December 2020

Na-K pump site density and ouabain binding affinity in cultured chick heart cells

1 reference

12 December 2020

Rapid release of 42K or 86Rb from two distinct transport sites on the Na,K-pump in the presence of Pi or vanadate

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1222308110

2 references

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3 March 2020

ADS bibcode

2013PNAS..11010958L

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1 reference

2 references

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3 March 2020

2 references

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