Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC) (Q27676846)

2

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Boguslaw Stec

3

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Laurie A Bankston

4

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Robert C Liddington

5

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Richard G DiScipio

Journal of Biological Chemistry

6

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language of work or name

English

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publication date

23 March 2012

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published in

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volume

287

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issue

13

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page(s)

10210-22

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cites work

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Features and development of Coot

20 March 2017

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Toward the structural genomics of complexes: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis

20 March 2017

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The integration of macromolecular diffraction data

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Generation, representation and flow of phase information in structure determination: recent developments in and around SHARP 2.0

20 March 2017

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A graphical user interface to the CCP4 program suite

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Structure and flexibility of the multiple domain proteins that regulate complement activation

20 March 2017

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Formation and structure of the C5b-7 complex of the lytic pathway of complement

29 September 2017

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Structural basis of pore formation by the bacterial toxin pneumolysin

20 March 2017

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Binding of human complement C8 to C9: role of the N-terminal modules in the C8 alpha subunit

20 March 2017

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Molecular organization of C9 within the membrane attack complex of complement. Induction of circular C9 polymerization by the C5b-8 assembly

20 March 2017

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20 March 2017

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The MACPF/CDC family of pore-forming toxins

7 April 2017

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Perforin-mediated target-cell death and immune homeostasis

29 September 2017

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Incorporation of human complement C8 into the membrane attack complex is mediated by a binding site located within the C8beta MACPF domain

29 September 2017

1 reference

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Complement C7 deficiency presenting as recurrent aseptic meningitis

29 September 2017

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Vertical collapse of a cytolysin prepore moves its transmembrane beta-hairpins to the membrane

29 September 2017

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The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues

29 September 2017

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Molecular basis of subtotal complement C6 deficiency. A carboxy-terminally truncated but functionally active C6.

29 September 2017

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29 September 2017

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The membrane attack complex of complement

29 September 2017

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Structure and function of human perforin

29 September 2017

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Homology of perforin to the ninth component of complement (C9).

29 September 2017

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29 September 2017

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Molecular nature of the complement lesion

29 September 2017

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Neoantigens of the membrane attack complex of human complement

29 September 2017

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Function of the factor I modules (FIMS) of human complement component C6.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323040

Mutation of recombinant complement component C9 reveals the significance of the N-terminal region for polymerization.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323040

Membrane attack complex of complement: a structural analysis of its assembly

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323040

Evidence of direct insertion of terminal complement proteins into cell membrane bilayers during cytolysis. Labeling by a photosensitive membrane probe reveals a major role for the eighth and ninth components

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323040

The membrane attack complex of complement: C5b-8 complex as accelerator of C9 polymerization.

2 June 2018

1 reference

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Comparison of channels formed by poly C9, C5b-8 and the membrane attack complex of complement

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323040

The structural events associated with the attachment of complement components to cell membranes in reactive lysis

2 June 2018

1 reference

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The C5b-6 complex: formation, isolation, and inhibition of its activity by lipoprotein and the S-protein of human serum

2 June 2018

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Evolutionary origin of the vertebrate blood complement and coagulation systems inferred from liver EST analysis of lamprey

2 June 2018

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The fractionation of human plasma proteins. II. The purification of human complement proteins C3, C3u, and C5 by application of affinity chromatography

21 January 2018

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Modified Phased Translation Functions and their Application to Molecular-Fragment Location

21 January 2018

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21 January 2018

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21 January 2018

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Recombinant C345C and factor I modules of complement components C5 and C7 inhibit C7 incorporation into the complement membrane attack complex

21 January 2018

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Molecular cloning of the terminal complement components C6 and C8beta of cartilaginous fish.

21 January 2018

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C6-like and C3-like molecules from the cephalochordate, amphioxus, suggest a cytolytic complement system in invertebrates.

21 January 2018

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Thermodynamics of protein-cation interaction: Ca+2 and Mg+2 binding to the fifth binding module of the LDL receptor

21 January 2018

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Complement component C6 deficiency and susceptibility to Neisseria meningitidis infections

21 January 2018

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The membrane attack mechanism of complement: photolabeling reveals insertion of terminal proteins into target membrane

27 November 2018

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Molecular composition of the tubular structure of the membrane attack complex of complement.

27 November 2018

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Detection of refolding conformers of complement protein C9 during insertion into membranes

27 November 2018

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Interaction of complement proteins C5b-6 and C5b-7 with phospholipid vesicles: effects of phospholipid structural features

21 January 2018

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12 December 2020

Improvements in the analysis of domain motions in proteins from conformational change: DynDom version 1.50

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12 December 2020

The terminal membrane C5b-9 complex of human complement. Evidence for the existence of multiple protease-resistant polypeptides that form the trans-membrane complement channel

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12 December 2020

Ultrastructure of the membrane attack complex of complement. Heterogeneity of the complex caused by different degree of C9 polymerization

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12 December 2020

[Hereditary C5 deficiency and recurrent Neisseria meningitidis meningitis]

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12 December 2020

Importance of the third thrombospondin repeat of C6 for terminal complement complex assembly

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Chimeric and truncated forms of human complement protein C8 alpha reveal binding sites for C8 beta and C8 gamma within the membrane attack complex/perforin region

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12 December 2020