Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons (Q27674359)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23047679%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

title

Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons (English)

1 reference

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amyotrophic lateral sclerosis

10 March 2020

main subject

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4

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10 March 2020

author name string

Nethaji Thiyagarajan

series ordinal

1

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10 March 2020

Ross Ferguson

series ordinal

2

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10 March 2020

Vasanta Subramanian

series ordinal

3

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10 March 2020

language of work or name

English

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publication date

1 January 2012

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10 March 2020

published in

Nature Communications

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10 March 2020

volume

3

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10 March 2020

page(s)

1121

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Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported

10 March 2020

copyright license

start time

1 January 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Angiogenin is translocated to the nucleus of HeLa cells and is involved in ribosomal RNA transcription and cell proliferation

20 March 2017

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Crystallographic studies on structural features that determine the enzymatic specificity and potency of human angiogenin: Thr44, Thr80, and residues 38-41

20 March 2017

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Crystallographic studies on the role of the C-terminal segment of human angiogenin in defining enzymatic potency

20 March 2017

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Crystal structure of human angiogenin reveals the structural basis for its functional divergence from ribonuclease

20 March 2017

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20 March 2017

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Site-directed mutagenesis of histidine-13 and histidine-114 of human angiogenin. Alanine derivatives inhibit angiogenin-induced angiogenesis

20 March 2017

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Characteristic ribonucleolytic activity of human angiogenin

20 March 2017

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20 March 2017

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20 March 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

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How to measure and predict the molar absorption coefficient of a protein

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Disruption of microtubules inhibits cytoplasmic ribonucleoprotein stress granule formation

20 March 2017

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Amino acid sequence of human tumor derived angiogenin

20 March 2017

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Interaction of human placental ribonuclease with placental ribonuclease inhibitor

20 March 2017

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Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue

20 March 2017

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A new role for angiogenin in neurite growth and pathfinding: implications for amyotrophic lateral sclerosis

20 March 2017

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Novel properties of the nucleolar targeting signal of human angiogenin

20 March 2017

1 reference

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Angiogenin variation and Parkinson disease

20 March 2017

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Altered RNA metabolism and amyotrophic lateral sclerosis

29 September 2017

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Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis

29 September 2017

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Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

29 September 2017

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Emerging role of angiogenin in stress response and cell survival under adverse conditions

29 September 2017

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Clinical diagnosis and management of amyotrophic lateral sclerosis

29 September 2017

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Clinical genetics of amyotrophic lateral sclerosis: what do we really know?

29 September 2017

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Angiogenin-induced tRNA fragments inhibit translation initiation

29 September 2017

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RNA-binding proteins and RNA metabolism: a new scenario in the pathogenesis of Amyotrophic lateral sclerosis

29 September 2017

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A neuroprotective role for angiogenin in models of Parkinson's disease

29 September 2017

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Human angiogenin presents neuroprotective and migration effects in neuroblastoma cells

29 September 2017

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Angiogenin-induced tRNA-derived stress-induced RNAs promote stress-induced stress granule assembly

29 September 2017

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29 September 2017

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Identification of novel Angiogenin (ANG) gene missense variants in German patients with amyotrophic lateral sclerosis

29 September 2017

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Angiogenin cleaves tRNA and promotes stress-induced translational repression

29 September 2017

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Human angiogenin is a neuroprotective factor and amyotrophic lateral sclerosis associated angiogenin variants affect neurite extension/pathfinding and survival of motor neurons.

29 September 2017

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Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis.

29 September 2017

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Angiogenin loss-of-function mutations in amyotrophic lateral sclerosis

29 September 2017

1 reference

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Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity.

29 September 2017

1 reference

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Role of glutamine-117 in the ribonucleolytic activity of human angiogenin.

29 September 2017

1 reference

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Isolation of male embryonal carcinoma cells and their chromosome replication patterns

29 September 2017

1 reference

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Mutagenesis of aspartic acid-116 enhances the ribonucleolytic activity and angiogenic potency of angiogenin

29 September 2017

1 reference

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A covalent angiogenin/ribonuclease hybrid with a fourth disulfide bond generated by regional mutagenesis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493651

Replacement of residues 8-22 of angiogenin with 7-21 of RNase A selectively affects protein synthesis inhibition and angiogenesis

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493651

Motoneurons secrete angiogenin to induce RNA cleavage in astroglia.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493651

Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates.

27 November 2018

1 reference

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Nuclear transport impairment of amyotrophic lateral sclerosis-linked mutations in FUS/TLS.

27 November 2018

1 reference

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Accumulation of TDP-43 and alpha-actin in an amyotrophic lateral sclerosis patient with the K17I ANG mutation.

27 November 2018

1 reference

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Angiogenin protects motoneurons against hypoxic injury.

27 November 2018

1 reference

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A case of ALS-FTD in a large FALS pedigree with a K17I ANG mutation.

27 November 2018

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Control of motoneuron survival by angiogenin.

27 November 2018

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Variations in the coding and regulatory sequences of the angiogenin (ANG) gene are not associated to ALS (amyotrophic lateral sclerosis) in the Italian population

27 November 2018

1 reference

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ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis.

27 November 2018

1 reference

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A novel candidate region for ALS on chromosome 14q11.2.

27 November 2018

1 reference

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High-Level Expression of Three Members of the Murine Angiogenin Family in Escherichia coli and Purification of the Recombinant Proteins

27 November 2018

1 reference

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The angiogenins: an emerging family of ribonuclease related proteins with diverse cellular functions

27 November 2018

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12 December 2020

Endogenous angiogenin in endothelial cells is a general requirement for cell proliferation and angiogenesis

1 reference

12 December 2020

A novel Angiogenin gene mutation in a sporadic patient with amyotrophic lateral sclerosis from southern Italy

1 reference

12 December 2020

Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis

1 reference

12 December 2020

Targeting angiogenin in therapy of amyotropic lateral sclerosis

1 reference

12 December 2020

Mutations of the ANG gene in French patients with sporadic amyotrophic lateral sclerosis

1 reference

12 December 2020

Amyotrophic lateral sclerosis

1 reference

12 December 2020

SOD1 G93D sporadic amyotrophic lateral sclerosis (SALS) patient with rapid progression and concomitant novel ANG variant

1 reference

12 December 2020

Identification of a novel missense mutation in angiogenin in a Chinese amyotrophic lateral sclerosis cohort

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

12 December 2020

Angiogenin abolishes cell-free protein synthesis by specific ribonucleolytic inactivation of 40S ribosomes

1 reference

12 December 2020

Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells

1 reference

12 December 2020

Structural features that determine the enzymatic potency and specificity of human angiogenin: threonine-80 and residues 58-70 and 116-123

1 reference

12 December 2020

Local RNA translation at the synapse and in disease

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS2126

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCOMMS2126

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23047679%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

10 March 2020

ADS bibcode

2012NatCo...3.1121T

0 references

1011174692

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23047679%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23047679%20AND%20SRC:MED&resulttype=core&format=json