Structural and Biochemical Characterization of ZhuI Aromatase/Cyclase from the R1128 Polyketide Pathway (Q27672158)

2

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Colleen Moody

3

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Wenjun Zhang

4

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Yi Tang

5

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Shiou-Chuan Tsai

Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization

6

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language of work or name

English

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publication date

4 October 2011

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published in

Biochemistry

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volume

50

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issue

39

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page(s)

8392-406

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cites work

1 reference

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Probing the Interactions of early polyketide intermediates with the Actinorhodin ACP from S. coelicolor A3(2)

20 March 2017

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Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase

20 March 2017

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The crystal structure of a mammalian fatty acid synthase

20 March 2017

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Crystal structure and functional analysis of tetracenomycin ARO/CYC: Implications for cyclization specificity of aromatic polyketides

20 March 2017

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Inhibition Kinetics and Emodin Cocrystal Structure of a Type II Polyketide Ketoreductase † , ‡

20 March 2017

1 reference

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Structural basis for substrate delivery by acyl carrier protein in the yeast fatty acid synthase

20 March 2017

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THE STRUCTURAL BIOLOGY OF TYPE II FATTY ACID BIOSYNTHESIS

20 March 2017

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Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthases

20 March 2017

1 reference

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Solution Structure and Backbone Dynamics of the Holo Form of the Frenolicin Acyl Carrier Protein,

20 March 2017

1 reference

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Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance

20 March 2017

1 reference

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Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2)

20 March 2017

1 reference

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Structural comparison of anticancer drug-DNA complexes: adriamycin and daunomycin

20 March 2017

1 reference

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Coot: model-building tools for molecular graphics

20 March 2017

1 reference

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

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The CCP4 suite: programs for protein crystallography

20 March 2017

1 reference

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Likelihood-enhanced fast rotation functions

20 March 2017

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SOLVE and RESOLVE: automated structure solution, density modification and model building

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189504

Substructure solution with SHELXD

20 March 2017

2 references

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20 March 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

29 September 2017

1 reference

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Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin

20 March 2017

1 reference

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Tamoxifen for the prevention of breast cancer: current status of the National Surgical Adjuvant Breast and Bowel Project P-1 study

20 March 2017

1 reference

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An antibiotic factory caught in action

20 March 2017

1 reference

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Development and validation of a genetic algorithm for flexible docking

20 March 2017

1 reference

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Improved protein-ligand docking using GOLD

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189504

Matthews coefficient probabilities: Improved estimates for unit cell contents of proteins, DNA, and protein-nucleic acid complex crystals

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189504

Cyclization of aromatic polyketides from bacteria and fungi

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189504

Structural enzymology of polyketide synthases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189504

Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189504

The type I fatty acid and polyketide synthases: a tale of two megasynthases

29 September 2017

1 reference

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Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189504

The anthracycline antibiotics: antitumor drugs that alter chromatin structure

29 September 2017

1 reference

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A gene cluster encoding resistomycin biosynthesis in Streptomyces resistomycificus; exploring polyketide cyclization beyond linear and angucyclic patterns

29 September 2017

1 reference

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Structural basis of perturbed pKa values of catalytic groups in enzyme active sites

29 September 2017

1 reference

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Genetic Contributions to Understanding Polyketide Synthases

29 September 2017

1 reference

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Adaptations of the helix-grip fold for ligand binding and catalysis in the START domain superfamily.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189504

Biosynthesis of polyketides (other than actinomycete macrolides).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189504

Deciphering the mechanism for the assembly of aromatic polyketides by a bacterial polyketide synthase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189504

Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189504

Cloning, sequencing, and analysis of the griseusin polyketide synthase gene cluster from Streptomyces griseus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189504

Binding and "pKa" modulation of a polycyclic substrate analogue in a type II polyketide acyl carrier protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189504

Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189504

Heterologous expression, purification, reconstitution and kinetic analysis of an extended type II polyketide synthase

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189504

Orchestration of discoid polyketide cyclization in the resistomycin pathway

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189504

Structural studies of fatty acyl-(acyl carrier protein) thioesters reveal a hydrophobic binding cavity that can expand to fit longer substrates.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189504

The structure of (3R)-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Pseudomonas aeruginosa.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189504

The acyltransferase homologue from the initiation module of the R1128 polyketide synthase is an acyl-ACP thioesterase that edits acetyl primer units.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189504

In vitro reconstitution and analysis of the chain initiating enzymes of the R1128 polyketide synthase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189504

Engineered biosynthesis of novel polyketides: properties of the whiE aromatase/cyclase.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189504

Domain analysis of the molecular recognition features of aromatic polyketide synthase subunits

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189504

Processing of X-ray diffraction data collected in oscillation mode

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21870821

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/BI200593M

1 reference

3098361

3098361

1 reference

1 reference

1 reference