Trimeric structure and flexibility of the L1ORF1 protein in human L1 retrotransposition (Q27671601)

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Oliver Weichenrieder

6

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Regina Büttner

3

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Vincent Truffault

2

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author name string

Elena Khazina

1

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Steffen Schmidt

4

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Murray Coles

Nature Structural & Molecular Biology

5

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publication date

7 August 2011

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published in

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volume

18

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page(s)

1006-14

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issue

9

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cites work

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LINE-1 retrotransposition activity in human genomes

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High-throughput sequencing reveals extensive variation in human-specific L1 content in individual human genomes

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Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: a mechanism for non-LTR retrotransposition

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Non-LTR retrotransposons encode noncanonical RRM domains in their first open reading frame

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Ribonucleoprotein particle formation is necessary but not sufficient for LINE-1 retrotransposition

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LINE-1 ORF1 protein localizes in stress granules with other RNA-binding proteins, including components of RNA interference RNA-induced silencing complex

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Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis

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Identification and solution structure of a highly conserved C-terminal domain within ORF1p required for retrotransposition of long interspersed nuclear element-1

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A coiled-coil motif that sequesters ions to the hydrophobic core

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Structure of the Rift Valley fever virus nucleocapsid protein reveals another architecture for RNA encapsidation

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The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA

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Determinants for DNA target structure selectivity of the human LINE-1 retrotransposon endonuclease

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Crystal structure of human T cell leukemia virus type 1 gp21 ectodomain crystallized as a maltose-binding protein chimera reveals structural evolution of retroviral transmembrane proteins

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Atomic structure of the ectodomain from HIV-1 gp41

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N- and C-terminal residues combine in the fusion-pH influenza hemagglutinin HA(2) subunit to form an N cap that terminates the triple-stranded coiled coil

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Natural mutagenesis of human genomes by endogenous retrotransposons

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L1 retrotransposition in human neural progenitor cells

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Human L1 retrotransposition: cis preference versus trans complementation

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LINE-1 retrotransposons: modulators of quantity and quality of mammalian gene expression?

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Mobile interspersed repeats are major structural variants in the human genome

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Human L1 element target-primed reverse transcription in vitro

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High frequency retrotransposition in cultured mammalian cells

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Ribonucleoprotein particles with LINE-1 RNA in mouse embryonal carcinoma cells

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Sequence-specific single-strand RNA binding protein encoded by the human LINE-1 retrotransposon

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In vitro properties of the first ORF protein from mouse LINE-1 support its role in ribonucleoprotein particle formation during retrotransposition

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Nucleic acid chaperone activity of the ORF1 protein from the mouse LINE-1 retrotransposon

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Trimeric structure for an essential protein in L1 retrotransposition

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Prediction of tight turns and their types in proteins.

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LINE-1 retrotransposition requires the nucleic acid chaperone activity of the ORF1 protein

21 January 2018

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A single amino acid substitution in ORF1 dramatically decreases L1 retrotransposition and provides insight into nucleic acid chaperone activity.

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Structural aspects of rabies virus replication

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Targeting of human retrotransposon integration is directed by the specificity of the L1 endonuclease for regions of unusual DNA structure.

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The esterase and PHD domains in CR1-like non-LTR retrotransposons

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A conserved trimerization motif controls the topology of short coiled coils

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Thermodynamic characterization of an engineered tetracycline-binding riboswitch

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Origins and Evolution of Retrotransposons

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Cytoplasmic ribonucleoprotein complexes containing human LINE-1 protein and RNA

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Spatial assembly and RNA binding stoichiometry of a LINE-1 protein essential for retrotransposition

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