Synthesis, Activity, and Structural Analysis of Novel α-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H (Q27667836)

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English	Synthesis, Activity, and Structural Analysis of Novel α-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H	scientific article

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Synthesis, Activity, and Structural Analysis of Novel α-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H (English)

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10

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Craig J. Thomas

object named as

Craig J Thomas

9

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ORCID Public Data File 2021

author name string

Suhman Chung

1

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Daniel M Himmel

2

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Jian-Kang Jiang

3

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Krzysztof Wojtak

4

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Joseph D Bauman

5

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Jason W Rausch

6

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Jennifer A Wilson

7

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John A Beutler

8

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Stuart F J Le Grice

11

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language of work or name

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publication date

14 July 2011

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Journal of Medicinal Chemistry

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54

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13

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4462-73

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Structural Basis for the Inhibition of RNase H Activity of HIV-1 Reverse Transcriptase by RNase H Active Site-Directed Inhibitors

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20 March 2017

Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site

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20 March 2017

RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information

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Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design

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High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations

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HIV-1 Reverse Transcriptase Structure with RNase H Inhibitor Dihydroxy Benzoyl Naphthyl Hydrazone Bound at a Novel Site

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20 March 2017

Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones

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A general two-metal-ion mechanism for catalytic RNA

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Structure of ribonuclease H phased at 2 A resolution by MAD analysis of the selenomethionyl protein

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20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

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20 March 2017

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20 March 2017

Automated refinement of protein models

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20 March 2017

ARP/wARP and molecular replacement

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20 March 2017

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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Crystal structure of Argonaute and its implications for RISC slicer activity

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7 April 2017

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7 April 2017

Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H.

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29 September 2017

Small molecule inhibitors of HIV RT Ribonuclease H.

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Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity

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Madurahydroxylactone derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and RNase H.

1 reference

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Geometry of nonbonded interactions involving planar groups in proteins

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29 September 2017

Recent progress in the design of small molecule inhibitors of HIV RNase H.

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29 September 2017

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1 reference

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Inhibition of human immunodeficiency virus type 1 reverse transcriptase, RNase H, and integrase activities by hydroxytropolones.

1 reference

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29 September 2017

Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: balance between RNase H activity and nucleotide excision

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29 September 2017

A fluorescence-based high-throughput screening assay for inhibitors of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H activity

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29 September 2017

Processing protease and reverse transcriptase from human immunodeficiency virus type I polyprotein in Escherichia coli

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29 September 2017

Human immunodeficiency virus type 1 reverse transcriptase: spatial and temporal relationship between the polymerase and RNase H activities

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Inhibition of HIV-1 ribonuclease H by a novel diketo acid, 4-[5-(benzoylamino)thien-2-yl]-2,4-dioxobutanoic acid

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2 June 2018

Complete nucleotide sequences of functional clones of the AIDS virus

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2 June 2018

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2 June 2018

Point mutations in conserved amino acid residues within the C-terminal domain of HIV-1 reverse transcriptase specifically repress RNase H function

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2 June 2018

Mutations within the RNase H Domain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Abolish Virus Infectivity

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2 June 2018

Relevant Anion-π Interactions in Biological Systems: The Case of Urate Oxidase

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27 November 2018

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27 November 2018

Geometry of interaction of the histidine ring with other planar and basic residues.

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27 November 2018

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27 November 2018

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https://pubmed.ncbi.nlm.nih.gov/21568335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of mitochondrial dysfunction and cytotoxicity induced by tropolones in isolated rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21568335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate-dependent inhibition or stimulation of HIV RNase H activity by non-nucleoside reverse transcriptase inhibitors (NNRTIs)

1 reference

https://pubmed.ncbi.nlm.nih.gov/21568335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM2000757

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Consolidated OpenCitations Corpus – April 2017

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OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

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