Structure-guided development of selective RabGGTase inhibitors (Q27667562)

9

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Herbert Waldmann

11

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Zhong Guo

Zhong Guo

2

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Robin S. Bon

Robin S Bon

1

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Kirill Alexandrov

Kirill Alexandrov

8

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Roger S. Goody

Roger S Goody

10

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author name string

E Anouk Stigter

3

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Stefan Wetzel

4

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Sascha Menninger

5

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Alexander Wolf

6

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Axel Choidas

Angewandte Chemie International Edition

7

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language of work or name

English

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publication date

16 May 2011

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published in

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volume

50

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issue

21

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page(s)

4957-61

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cites work

Rab proteins as membrane organizers

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Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases.

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Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I

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The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers

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The endocytic catalysts, Rab5a and Rab7, are tandem regulators of thyroid hormone production

21 January 2018

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Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors

21 January 2018

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Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies

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Non-peptidic prenyltransferase inhibitors: diverse structural classes and surprising anti-cancer mechanisms

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Inhibitors of protein: geranylgeranyl transferases

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Lipid posttranslational modifications. Farnesyl transferase inhibitors

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Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets

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Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.

21 January 2018

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Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds

21 January 2018

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Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors

21 January 2018

1 reference

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Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase.

21 January 2018

1 reference

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Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid.

21 January 2018

1 reference

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Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex

21 January 2018

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Analysis of the eukaryotic prenylome by isoprenoid affinity tagging

21 January 2018

1 reference

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Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity

21 January 2018

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Steady-state kinetic mechanism of Ras farnesyl:protein transferase

21 January 2018

1 reference

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Synthesis of a fluorescent analogue of geranylgeranyl pyrophosphate and its use in a high-throughput fluorometric assay for Rab geranylgeranyltransferase

21 January 2018

1 reference

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A Protein Fluorescence Amplifier: Continuous Fluorometric Assay for Rab Geranylgeranyltransferase

21 January 2018

1 reference

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release_ytbpd3cxtrb4pldq55ypjn4gmi

21 January 2018

Identifiers

DOI

10.1002/ANIE.201101210

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Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ytbpd3cxtrb4pldq55ypjn4gmi