Combined X-ray, NMR, and Kinetic Analyses Reveal Uncommon Binding Characteristics of the Hepatitis C Virus NS3-NS4A Protease Inhibitor BI 201335 (Q27666747)

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English	Combined X-ray, NMR, and Kinetic Analyses Reveal Uncommon Binding Characteristics of the Hepatitis C Virus NS3-NS4A Protease Inhibitor BI 201335	scientific article

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scholarly article

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Combined X-ray, NMR, and Kinetic Analyses Reveal Uncommon Binding Characteristics of the Hepatitis C Virus NS3-NS4A Protease Inhibitor BI 201335 (English)

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Hepatitis C virus

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based on heuristic

inferred from title

author name string

Christopher T Lemke

1

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Nathalie Goudreau

2

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Songping Zhao

3

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Oliver Hucke

4

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Diane Thibeault

5

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Montse Llinàs-Brunet

6

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Peter W White

7

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language of work or name

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publication date

1 April 2011

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Journal of Biological Chemistry

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286

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13

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11434-43

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Induced-fit binding of the macrocyclic noncovalent inhibitor TMC435 to its HCV NS3/NS4A protease target

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Binding of a noncovalent inhibitor exploiting the S' region stabilizes the hepatitis C virus NS3 protease conformation in the absence of cofactor

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20 March 2017

Halogen bonds in biological molecules

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Virus-specific cofactor requirement and chimeric hepatitis C virus/GB virus B nonstructural protein 3

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20 March 2017

Inhibitor binding induces active site stabilization of the HCV NS3 protein serine protease domain

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20 March 2017

Inhibition of the hepatitis C virus NS3/4A protease. The crystal structures of two protease-inhibitor complexes

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20 March 2017

Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase

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20 March 2017

The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism

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20 March 2017

Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus

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20 March 2017

Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide

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20 March 2017

Complex formation between the NS3 serine-type proteinase of the hepatitis C virus and NS4A and its importance for polyprotein maturation

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20 March 2017

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20 March 2017

Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome

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20 March 2017

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7 April 2017

An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus

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7 April 2017

Preclinical characterization of BI 201335, a C-terminal carboxylic acid inhibitor of the hepatitis C virus NS3-NS4A protease

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29 September 2017

Hepatitis C virus NS3 protease is activated by low concentrations of protease inhibitors.

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29 September 2017

Current and future treatment options for HCV.

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29 September 2017

Telaprevir: a promising protease inhibitor for the treatment of hepatitis C virus infection.

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Boceprevir, an NS3 serine protease inhibitor of hepatitis C virus, for the treatment of HCV infection

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29 September 2017

The role of halogen bonding in inhibitor recognition and binding by protein kinases.

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29 September 2017

The therapeutic potential of NS3 protease inhibitors in HCV infection

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29 September 2017

Short-term antiviral efficacy of BILN 2061, a hepatitis C virus serine protease inhibitor, in hepatitis C genotype 1 patients.

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29 September 2017

Structural basis of perturbed pKa values of catalytic groups in enzyme active sites

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29 September 2017

Solution structure and dynamics of the single-chain hepatitis C virus NS3 protease NS4A cofactor complex

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29 September 2017

The metal binding site of the hepatitis C virus NS3 protease. A spectroscopic investigation.

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29 September 2017

Tautomeric states of the active-site histidines of phosphorylated and unphosphorylated IIIGlc, a signal-transducing protein from Escherichia coli, using two-dimensional heteronuclear NMR techniques

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2 June 2018

Discovery of a potent and selective noncovalent linear inhibitor of the hepatitis C virus NS3 protease (BI 201335).

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21 January 2018

Use of the fused NS4A peptide-NS3 protease domain to study the importance of the helicase domain for protease inhibitor binding to hepatitis C virus NS3-NS4A.

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21 January 2018

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Inhibition and binding kinetics of the hepatitis C virus NS3 protease inhibitor ITMN-191 reveals tight binding and slow dissociative behavior

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Potency, safety, and pharmacokinetics of the NS3/4A protease inhibitor BI201335 in patients with chronic HCV genotype-1 infection

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van der Waals Volumes and Radii

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21 January 2018

Observation of a short, strong hydrogen bond in the active site of hydroxynitrile lyase from Hevea brasiliensis explains a large pKa shift of the catalytic base induced by the reaction intermediate

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21 January 2018

The X-ray crystal structure analysis of the refined complex formed by bovine trypsin and p-amidinophenylpyruvate at 1.4 A resolution

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Protonation-state dependence of hydrogen bond strengths and exchange rates in a serine protease catalytic triad: bovine chymotrypsinogen A

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10.1074/JBC.M110.211417

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