A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo (Q27665195)

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Stefania Di Marco

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Jon H Condra

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Laurence B Peterson

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Weirong Wang

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Fubao Wang

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Shilpa Pandit

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Holly A Hammond

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Ray Rosa

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Richard T Cummings

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Dana D Wood

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Xiaomei Liu

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Matthew J Bottomley

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Xun Shen

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Sheng-ping Wang

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Douglas G Johns

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Cinzia Volpari

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Lora Hamuro

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Jayne Chin

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Lingyi Huang

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Jing Zhang Zhao

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Salvatore Vitelli

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Peter Haytko

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Douglas Wisniewski

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Lyndon J Mitnaul

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Carl P Sparrow

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Brian Hubbard

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Andrea Carfí

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Ayesha Sitlani

Journal of Lipid Research

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publication date

January 2011

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published in

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volume

52

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issue

1

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page(s)

78-86

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cites work

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Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells

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Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants

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Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants

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NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

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Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

20 March 2017

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Molecular biology of PCSK9: its role in LDL metabolism

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Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

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The CCP4 suite: programs for protein crystallography

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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

20 March 2017

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Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor

20 March 2017

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Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

20 March 2017

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Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

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High-dose atorvastatin causes a rapid sustained increase in human serum PCSK9 and disrupts its correlation with LDL cholesterol

7 April 2017

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A proprotein convertase subtilisin-like/kexin type 9 (PCSK9) C-terminal domain antibody antigen-binding fragment inhibits PCSK9 internalization and restores low density lipoprotein uptake

29 September 2017

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Affinity maturation and characterization of a human monoclonal antibody against HIV-1 gp41

29 September 2017

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A new method for measurement of total plasma PCSK9: clinical applications

29 September 2017

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Genetic and metabolic determinants of plasma PCSK9 levels

29 September 2017

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Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor

29 September 2017

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PCSK9 binds to multiple receptors and can be functionally inhibited by an EGF-A peptide.

29 September 2017

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Plasma PCSK9 preferentially reduces liver LDL receptors in mice

29 September 2017

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Functional analysis of sites within PCSK9 responsible for hypercholesterolemia

29 September 2017

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The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies.

29 September 2017

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Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation

29 September 2017

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A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol.

29 September 2017

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Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

29 September 2017

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A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree

29 September 2017

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Secreted proprotein convertase subtilisin/kexin type 9 reduces both hepatic and extrahepatic low-density lipoprotein receptors in vivo

29 September 2017

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IgG2m4, an engineered antibody isotype with reduced Fc function

21 January 2018

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PROCHECK: a program to check the stereochemical quality of protein structures

21 January 2018

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Molecular basis for LDL receptor recognition by PCSK9

21 January 2018

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Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy

21 January 2018

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Regulation of hepatic cholesterol metabolism in CETP/LDLr mice by cholesterol feeding and by drugs (cholestyramine and lovastatin) that lower plasma cholesterol.

21 January 2018

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Elevation of plasma phospholipid transfer protein increases the risk of atherosclerosis despite lower apolipoprotein B-containing lipoproteins

21 January 2018

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