Disrupted Zinc-Binding Sites in Structures of Pathogenic SOD1 Variants D124V and H80R (Q27662078)

9

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author name string

Sai V Seetharaman

1

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Duane D Winkler

2

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Alexander B Taylor

3

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Xiaohang Cao

4

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Lisa J Whitson

5

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Peter A Doucette

6

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Joan S Valentine

7

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Virgil Schirf

8

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Mark C Carroll

10

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Valeria C Culotta

11

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P John Hart

Characterization of a Covalent Polysulfane Bridge in Copper−Zinc Superoxide Dismutase,

12

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language of work or name

English

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publication date

13 July 2010

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published in

Biochemistry

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volume

49

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issue

27

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page(s)

5714-25

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cites work

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Structural and Biophysical Properties of the Pathogenic SOD1 Variant H46R/H48Q †

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An alternative mechanism of bicarbonate-mediated peroxidation by copper-zinc superoxide dismutase: rates enhanced via proposed enzyme-associated peroxycarbonate intermediate

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Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

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Modifications of superoxide dismutase (SOD1) in human erythrocytes: a possible role in amyotrophic lateral sclerosis

29 September 2017

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The effects of glutaredoxin and copper activation pathways on the disulfide and stability of Cu,Zn superoxide dismutase

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Pathogenic superoxide dismutase structure, folding, aggregation and turnover

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Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis

29 September 2017

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29 September 2017

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Oxygen and the copper chaperone CCS regulate posttranslational activation of Cu,Zn superoxide dismutase

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Modification of cysteine 111 in human Cu,Zn-superoxide dismutase

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Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg.

2 June 2018

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2 June 2018

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2 June 2018

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Loss of in vitro metal ion binding specificity in mutant copper-zinc superoxide dismutases associated with familial amyotrophic lateral sclerosis

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ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

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Labile Sulfur in Human Superoxide Dismutase

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A two-dimensional spectrum analysis for sedimentation velocity experiments of mixtures with heterogeneity in molecular weight and shape

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Oxidative modification to cysteine sulfonic acid of Cys111 in human copper-zinc superoxide dismutase

27 November 2018

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Variable Metallation of Human Superoxide Dismutase: Atomic Resolution Crystal Structures of Cu–Zn, Zn–Zn and As-isolated Wild-type Enzymes

27 November 2018

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Dissociation of human copper-zinc superoxide dismutase dimers using chaotrope and reductant. Insights into the molecular basis for dimer stability

27 November 2018

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Heterodimer formation between superoxide dismutase and its copper chaperone

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12 December 2020

The unusually stable quaternary structure of human Cu,Zn-superoxide dismutase 1 is controlled by both metal occupancy and disulfide status

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12 December 2020

Somatodendritic accumulation of misfolded SOD1-L126Z in motor neurons mediates degeneration: alphaB-crystallin modulates aggregation

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12 December 2020

A characterization of copper/zinc superoxide dismutase mutants at position 124. Zinc-deficient proteins

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

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12 December 2020

Reactions of hydrogen peroxide with familial amyotrophic lateral sclerosis mutant human copper-zinc superoxide dismutases studied by pulse radiolysis

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12 December 2020