X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct (Q27661393)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20448203%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct (English)

1 reference

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DNA-directed RNA polymerase core subunit RPB5 YBR154C

1 February 2020

main subject

1 reference

DNA-directed RNA polymerase II core subunit RPB2 YOR151C

GOA release 2020-03-11

1 reference

DNA-directed RNA polymerase core subunit RPB8 YOR224C

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20448203%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Xuhui Huang

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20448203%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

author name string

Dong Wang

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20448203%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Stephen J Lippard

series ordinal

4

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1 February 2020

language of work or name

English

0 references

publication date

6 May 2010

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

1 February 2020

published in

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1 February 2020

volume

107

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1 February 2020

page(s)

9584-9589

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1 February 2020

issue

21

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Structural Basis of Transcription: Backtracked RNA Polymerase II at 3.4 Angstrom Resolution

1 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

cis -Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

Mechanism of transcriptional stalling at cisplatin-damaged DNA

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

CPD damage recognition by transcribing RNA polymerase II

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

Structural basis of transcription: separation of RNA from DNA by RNA polymerase II

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

The primary mode of binding of cisplatin to a B-DNA dodecamer: C-G-C-G-A-A-T-T-C-G-C-G

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

Coot: model-building tools for molecular graphics

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

Development and testing of a general amber force field

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

Automatic atom type and bond type perception in molecular mechanical calculations

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

Cellular processing of platinum anticancer drugs

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

Phenanthroline derivatives with improved selectivity as DNA-targeting anticancer or antimicrobial drugs

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

Direct cellular responses to platinum-induced DNA damage

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

Inversion of the cis geometry requirement for cytotoxicity in structurally novel platinum(II) complexes containing the bidentate N,O-donor pyridin-2-yl-acetate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

DNA interstrand cross-links of trans-diamminedichloroplatinum(II) are preferentially formed between guanine and complementary cytosine residues

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

Intrinsic transcript cleavage activity of RNA polymerase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

Interstrand cross-links are preferentially formed at the d(GC) sites in the reaction between cis-diamminedichloroplatinum (II) and DNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

Spontaneous cleavage of RNA in ternary complexes of Escherichia coli RNA polymerase and its significance for the mechanism of transcription

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

Binding of cis - and trans -Dichlorodiammineplatinum(II) to DNA: Evidence for Unwinding and Shortening of the Double Helix

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

Correlation between the toxicity of platinum drugs to L1210 leukaemia cells and their mutagenic properties

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906855

Structure, Recognition, and Processing of Cisplatin-DNA Adducts.

29 September 2017

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1002565107

Spectrum of DNA--platinum adduct recognition by prokaryotic and eukaryotic DNA-dependent RNA polymerases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1002565107

Behavior of T7 RNA polymerase and mammalian RNA polymerase II at site-specific cisplatin adducts in the template DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1002565107

Fate of RNA polymerase II stalled at a cisplatin lesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1002565107

RNA polymerase II blockage by cisplatin-damaged DNA. Stability and polyubiquitylation of stalled polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1002565107

Monofunctional and Interstrand DNA Adducts of Platinum(II) Complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1002565107

Energetics, conformation, and recognition of DNA duplexes modified by methylated analogues of [PtCl(dien)]+.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1002565107

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1002565107

GROMACS 3.0: a package for molecular simulation and trajectory analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1002565107

Rapid fluorescence-based reporter-gene assays to evaluate the cytotoxicity and antitumor drug potential of platinum complexes

21 January 2018

1 reference

12 December 2020

Mechanistic studies of a novel class of trisubstituted platinum(II) antitumor agents

1 reference

12 December 2020

Chemical and biological properties of a new series of cis-diammineplatinum(II) antitumor agents containing three nitrogen donors: cis-[Pt(NH3)2(N-donor)Cl]+

1 reference

12 December 2020

Platinum-amine compounds: importance of the labile and inert ligands for their pharmacological activities toward L1210 leukemia cells

1 reference

12 December 2020

DNA adducts of cis-diamminedichloroplatinum(II) and its trans isomer inhibit RNA polymerase II differentially in vivo

1 reference

12 December 2020

Monofunctional adducts of platinum(II) produce in DNA a sequence-dependent local denaturation

1 reference

12 December 2020

DNA interactions of a novel platinum drug, cis-[PtCl(NH3)2(N7-acyclovir)]+

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1002565107

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20448203%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

0 references

1 reference

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1 February 2020

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