Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins (Q27658223)

3

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Vern L. Schramm

4

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author name string

Meng-Chiao Ho

1

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Matthew B Sturm

Proceedings of the National Academy of Sciences of the United States of America

2

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language of work or name

English

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publication date

1 December 2009

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published in

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volume

106

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issue

48

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page(s)

20276-81

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cites work

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Ribosome-inactivating proteins from the seeds of Saponaria officinalis L. (soapwort), of Agrostemma githago L. (corn cockle) and of Asparagus officinalis L. (asparagus), and from the latex of Hura crepitans L. (sandbox tree)

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A phase I study of combination therapy with immunotoxins IgG-HD37-deglycosylated ricin A chain (dgA) and IgG-RFB4-dgA (Combotox) in patients with refractory CD19(+), CD22(+) B cell lymphoma

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29 September 2017

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29 September 2017

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Ricin A-chain and ricin A-chain immunotoxins rapidly damage human endothelial cells: implications for vascular leak syndrome

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Distribution and properties of major ribosome-inactivating proteins (28 S rRNA N-glycosidases) of the plant Saponaria officinalis L. (Caryophyllaceae).

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The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins.

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Structure of a ricin mutant showing rescue of activity by a noncatalytic residue

2 June 2018

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Linkage-specific α-D-galactosidases fromTrichomonas foetus: Characterisation of the blood-group B-destroying enzyme as A 1,3-α-galactosidase and the blood-group P1-destroying enzyme as A 1,4-α-galactosidase

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Leaving group activation by aromatic stacking: an alternative to general acid catalysis

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Polynucleotide:adenosine glycosidase activity of saporin-L1: effect on various forms of mammalian DNA

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A phase I study of an anti-CD22-deglycosylated ricin A chain immunotoxin in the treatment of B-cell lymphomas resistant to conventional therapy.

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The effect of a monoclonal antibody coupled to ricin A chain-derived peptides on endothelial cells in vitro: insights into toxin-mediated vascular damage

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Ribosome inactivation by the toxic lectins abrin and ricin. Kinetics of the enzymic activity of the toxin A-chains

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Analysis of several key active site residues of ricin A chain by mutagenesis and X-ray crystallography

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Continuous infusion of the anti-CD22 immunotoxin IgG-RFB4-SMPT-dgA in patients with B-cell lymphoma: a phase I study

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Complete sustained response of a refractory, post-transplantation, large B-cell lymphoma to an anti-CD22 immunotoxin

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Synthesis and biochemical evaluation of RNA containing an intrahelical disulfide crosslink

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