Structural and Metabolic Specificity of Methylthiocoformycin for Malarial Adenosine Deaminases (Q27657289)

8

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Kami Kim

object named as

Kami Kim

6

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Dennis C Madrid

3

object named as

Dennis C Madrid

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author name string

Meng-Chiao Ho

1

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María B Cassera

2

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Li-Min Ting

4

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Peter C Tyler

Structures of Substrate- and Inhibitor-Bound Adenosine Deaminase from a Human Malaria Parasite Show a Dramatic Conformational Change and Shed Light on Drug Selectivity

5

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language of work or name

English

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publication date

13 October 2009

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published in

Biochemistry

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volume

48

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issue

40

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page(s)

9618-26

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cites work

1 reference

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The global distribution of clinical episodes of Plasmodium falciparum malaria

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Genome sequence of the human malaria parasite Plasmodium falciparum

20 March 2017

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Complexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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Targeting a novel Plasmodium falciparum purine recycling pathway with specific immucillins

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Targeting purine and pyrimidine metabolism in human apicomplexan parasites

20 March 2017

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Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique

7 April 2017

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Drug-resistant malaria - an insight

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Synthesis of 5'-methylthio coformycins: specific inhibitors for malarial adenosine deaminase

29 September 2017

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An improved and highly sensitive microfluorimetric method for assessing susceptibility of Plasmodium falciparum to antimalarial drugs in vitro

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Drug-resistant malaria

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Methionine synthesis from 5'-S-Methylthioadenosine. Resolution of enzyme activities and identification of 1-phospho-5-S methylthioribulose.

29 September 2017

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Host-parasite interactions revealed by Plasmodium falciparum metabolomics

29 September 2017

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Erythrocytic adenosine monophosphate as an alternative purine source in Plasmodium falciparum.

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Transition-state structure of human 5'-methylthioadenosine phosphorylase

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The deamination of adenosine and adenosine monophosphate in Plasmodium falciparum-infected human erythrocytes: in vitro use of 2'deoxycoformycin and AMP deaminase-deficient red cells

2 June 2018

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Adenosine deaminase in malaria infection: effect of 2'-deoxycoformycin in vivo.

27 November 2018

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Processing of X-ray diffraction data collected in oscillation mode

27 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/19728741