Reaction mechanism of glutamate carboxypeptidase II revealed by mutagenesis, X-ray crystallography, and computational methods (Q27654221)

2

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Jan Konvalinka

5

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Anna Plechanovová

3

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Jacek Lubkowski

7

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Petra Mlcochova

4

object named as

Petra Mlcochová

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Vojtech Klusák

1

object named as

Vojtech Klusák

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author name string

Lubomír Rulísek

The coordination of the catalytic zinc in alcohol dehydrogenase studied by combined quantum-chemical and molecular mechanics calculations

6

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language of work or name

English

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publication date

19 May 2009

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published in

Biochemistry

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volume

48

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issue

19

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page(s)

4126-38

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cites work

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Expression of glutamate carboxypeptidase II in human brain

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Substrate specificity, inhibition and enzymological analysis of recombinant human glutamate carboxypeptidase II.

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Structure of membrane glutamate carboxypeptidase.

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Structural Basis of Interactions between Human Glutamate Carboxypeptidase II and Its Substrate Analogs

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Co-catalytic metallopeptidases as pharmaceutical targets

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Site-directed mutagenesis of predicted active site residues in glutamate carboxypeptidase II.

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Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury

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Crystal structure of Aeromonas proteolytica aminopeptidase: a prototypical member of the co-catalytic zinc enzyme family

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Processing of X-ray diffraction data collected in oscillation mode

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Streptomyces griseus aminopeptidase: X-ray crystallographic structure at 1.75 A resolution

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Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II

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Mapping of the active site of glutamate carboxypeptidase II by site-directed mutagenesis

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Changes in zinc ligation promote remodeling of the active site in the zinc hydrolase superfamily

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Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer

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A high-resolution structure of ligand-free human glutamate carboxypeptidase II

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The Reaction Mechanism of Bovine Lens Leucine Aminopeptidase

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Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy.

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Peptide hydrolysis by the binuclear zinc enzyme aminopeptidase from Aeromonas proteolytica: a density functional theory study

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Two-metal ion mechanism of bovine lens leucine aminopeptidase: active site solvent structure and binding mode of L-leucinal, a gem-diolate transition state analogue, by X-ray crystallography

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