Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis (Q27653610)

9

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Rajan Sankaranarayanan

object named as

Rajan Sankaranarayanan

11

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author name string

Aneesh Goyal

2

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Vivek T Natarajan

3

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Eerappa Rajakumara

4

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Priyanka Verma

5

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Radhika Gupta

6

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Malikmohamed Yousuf

7

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Omita A Trivedi

8

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Anil Tyagi

10

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Rajesh S Gokhale

Identification of a type III thioesterase reveals the function of an operon crucial for Mtb virulence

12

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publication date

March 2009

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published in

Nature Chemical Biology

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volume

5

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page(s)

166-73

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issue

3

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cites work

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20 March 2017

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Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases

20 March 2017

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Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase

20 March 2017

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Antimycobacterial activities of isoxyl and new derivatives through the inhibition of mycolic acid synthesis

20 March 2017

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Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

20 March 2017

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Structural basis for the activation of phenylalanine in the non-ribosomal biosynthesis of gramicidin S

20 March 2017

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Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes

20 March 2017

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20 March 2017

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20 March 2017

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Improved methods for building protein models in electron density maps and the location of errors in these models

20 March 2017

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Exploring complex networks

20 March 2017

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Structural basis of the substrate-specific two-step catalysis of long chain fatty acyl-CoA synthetase dimer

20 March 2017

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A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages

20 March 2017

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A genetic locus required for iron acquisition in Mycobacterium tuberculosis

20 March 2017

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Dissecting the mechanism and assembly of a complex virulence mycobacterial lipid

20 March 2017

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The acyl-AMP ligase FadD32 and AccD4-containing acyl-CoA carboxylase are required for the synthesis of mycolic acids and essential for mycobacterial growth: identification of the carboxylation product and determination of the acyl-CoA carboxylase co

20 March 2017

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Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria

20 March 2017

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Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier

20 March 2017

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Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice

20 March 2017

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Global transcriptional profile of Mycobacterium tuberculosis during THP-1 human macrophage infection

20 March 2017

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Targeting the formation of the cell wall core of M. tuberculosis

29 September 2017

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Versatility of polyketide synthases in generating metabolic diversity.

29 September 2017

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Versatile polyketide enzymatic machinery for the biosynthesis of complex mycobacterial lipids.

29 September 2017

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Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling.

29 September 2017

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The cell-wall core of Mycobacterium tuberculosis in the context of drug discovery

29 September 2017

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Long-chain multiple methyl-branched fatty acid-containing lipids of Mycobacterium tuberculosis: biosynthesis, transport, regulation and biological activities

29 September 2017

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Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.

29 September 2017

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Yeast acyl-CoA synthetases at the crossroads of fatty acid metabolism and regulation

29 September 2017

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Crystallization and preliminary X-ray crystallographic studies of the N-terminal domain of FadD28, a fatty-acyl AMP ligase from Mycobacterium tuberculosis

29 September 2017

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Cell-signalling dynamics in time and space

29 September 2017

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Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis

29 September 2017

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Designed multiple ligands. An emerging drug discovery paradigm

29 September 2017

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M. tuberculosis persistence, latency, and drug tolerance

29 September 2017

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Exploring the domain structure of modular nonribosomal peptide synthetases

29 September 2017

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The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases

29 September 2017

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The behavior and significance of slow-binding enzyme inhibitors

29 September 2017

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Biochemistry and molecular genetics of cell-wall lipid biosynthesis in mycobacteria

29 September 2017

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Synthesis and antiviral activity of 5'-O-(substituted) sulfamoyl pyrimidine nucleosides

2 June 2018

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Rationally designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis

2 June 2018

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Promiscuous fatty acyl CoA ligases produce acyl-CoA and acyl-SNAC precursors for polyketide biosynthesis

21 January 2018

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PROCHECK: a program to check the stereochemical quality of protein structures

21 January 2018

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SETOR: hardware-lighted three-dimensional solid model representations of macromolecules

21 January 2018

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The soluble acyl-acyl carrier protein synthetase of Vibrio harveyi B392 is a member of the medium chain acyl-CoA synthetase family

21 January 2018

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12 December 2020

Acyl-Phosphates Initiate Membrane Phospholipid Synthesis in Gram-Positive Pathogens

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12 December 2020

Aminoacyl-coenzyme A synthesis catalyzed by adenylation domains

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12 December 2020

The loading module of mycosubtilin: an adenylation domain with fatty acid selectivity

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12 December 2020