Triclosan Derivatives: Towards Potent Inhibitors of Drug-Sensitive and Drug-ResistantMycobacterium tuberculosis (Q27653366)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19130456%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

title

Triclosan derivatives: towards potent inhibitors of drug-sensitive and drug-resistant Mycobacterium tuberculosis (English)

1 reference

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Mycobacterium tuberculosis

19 January 2020

main subject

organic chemistry

0 references

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2

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19 January 2020

Gulcin Gulten

4

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19 January 2020

William Jacobs

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19 January 2020

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Joel S Freundlich

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19 January 2020

author name string

Catherine Vilchèze

3

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19 January 2020

Robert Langley

5

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19 January 2020

Guy A Schiehser

6

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19 January 2020

David P Jacobus

7

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19 January 2020

James C Sacchettini

9

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19 January 2020

publication date

1 February 2009

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19 January 2020

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19 January 2020

volume

4

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19 January 2020

page(s)

241-248

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19 January 2020

issue

2

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X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy

19 January 2020

cites work

1 reference

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Mechanism of thioamide drug action against tuberculosis and leprosy

20 March 2017

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Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data

20 March 2017

1 reference

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Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase

20 March 2017

1 reference

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Crystallographic analysis of triclosan bound to enoyl reductase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541007

Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, InhA, in complex with NAD+ and a C16 fatty acyl substrate

20 March 2017

1 reference

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Molecular basis of triclosan activity

20 March 2017

1 reference

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Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis

20 March 2017

1 reference

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Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis

20 March 2017

1 reference

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The CCP4 suite: programs for protein crystallography

20 March 2017

1 reference

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XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density

20 March 2017

1 reference

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SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

20 March 2017

1 reference

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Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis

20 March 2017

1 reference

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Triclosan targets lipid synthesis

20 March 2017

1 reference

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The enoyl-[acyl-carrier-protein] reductases FabI and FabL from Bacillus subtilis

20 March 2017

1 reference

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Characterization of Pseudomonas aeruginosa enoyl-acyl carrier protein reductase (FabI): a target for the antimicrobial triclosan and its role in acylated homoserine lactone synthesis

20 March 2017

1 reference

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Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis

20 March 2017

1 reference

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inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541007

Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum

7 April 2017

1 reference

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The mechanism of isoniazid killing: clarity through the scope of genetics

24 May 2017

1 reference

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Population genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobacterium tuberculosis.

29 September 2017

1 reference

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Emergence of Mycobacterium tuberculosis with extensive resistance to second-line drugs--worldwide, 2000-2004.

29 September 2017

1 reference

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ethA, inhA, and katG loci of ethionamide-resistant clinical Mycobacterium tuberculosis isolates

29 September 2017

1 reference

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Broad spectrum antimicrobial biocides target the FabI component of fatty acid synthesis

29 September 2017

1 reference

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Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.

2 June 2018

1 reference

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Triclosan as a substrate and inhibitor of 3'-phosphoadenosine 5'-phosphosulfate-sulfotransferase and UDP-glucuronosyl transferase in human liver fractions

27 November 2018

1 reference

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High Affinity InhA Inhibitors with Activity against Drug-Resistant Strains ofMycobacterium tuberculosis

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19130456

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Processing of X-ray diffraction data collected in oscillation mode

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19130456

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/CMDC.200800261

2 references

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19 January 2020

1 reference

2 references

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19 January 2020

2 references