Structural analysis of human glutamine:fructose-6-phosphate amidotransferase, a key regulator in type 2 diabetes (Q27653066)

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Hiroshi Shimizu

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Kenji Watanabe

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Fumitaka Goto

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Hideaki Tsuge

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Kazumi Kondo

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Makoto Komatsu

The pathobiology of diabetic complications: a unifying mechanism

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language of work or name

English

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publication date

5 January 2009

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published in

FEBS Letters

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volume

583

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issue

1

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page(s)

163-7

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cites work

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Common variants in glutamine:fructose-6-phosphate amidotransferase 2 (GFPT2) gene are associated with type 2 diabetes, diabetic nephropathy, and increased GFPT2 mRNA levels

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Pre-exposure to glucosamine induces insulin resistance of glucose transport and glycogen synthesis in isolated rat skeletal muscles. Study of mechanisms in muscle and in rat-1 fibroblasts overexpressing the human insulin receptor

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In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats

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Hexosamines, insulin resistance, and the complications of diabetes: current status

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Novel approaches in the rational design of antifungal agents of low toxicity

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cDNA cloning and mapping of a novel subtype of glutamine:fructose-6-phosphate amidotransferase (GFAT2) in human and mouse

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Identification of GFAT1-L, a novel splice variant of human glutamine: fructose-6-phosphate amidotransferase (GFAT1) that is expressed abundantly in skeletal muscle

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Glucosamine-6-phosphate synthase--the multi-facets enzyme.

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Involvement of the C terminus in intramolecular nitrogen channeling in glucosamine 6-phosphate synthase: evidence from a 1.6 A crystal structure of the isomerase domain

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Channeling of ammonia in glucosamine-6-phosphate synthase

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Glutamine binding opens the ammonia channel and activates glucosamine-6P synthase

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The crystal and solution studies of glucosamine-6-phosphate synthase from Candida albicans

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Processing of X-ray diffraction data collected in oscillation mode

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Molecular therapeutic target for type-2 diabetes

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Identification of a novel serine phosphorylation site in human glutamine:fructose-6-phosphate amidotransferase isoform 1.

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Expression and purification of active human internal His(6)-tagged L-glutamine: D-Fructose-6P amidotransferase I.

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Purification and characterization of glutamine:fructose 6-phosphate amidotransferase from rat liver

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