Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization (Q27652525)

GOA release 2020-03-11

Serpin family C member 1

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identical protein binding

GOA release 2020-03-11

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GOA release 2020-03-11

author name string

Masayuki Yamasaki

1

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Wei Li

2

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Daniel J D Johnson

3

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James A Huntington

Serpinopathies and the conformational dementias

4

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language of work or name

English

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publication date

30 October 2008

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published in

Nature

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volume

455

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page(s)

1255-8

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issue

7217

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cites work

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https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Molecular mousetraps and the serpinopathies

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https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Conformational disease

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https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

The mechanism of Z alpha 1-antitrypsin accumulation in the liver

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https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Polymerisation underlies alpha1-antitrypsin deficiency, dementia and other serpinopathies

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https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Structure of a serpin-protease complex shows inhibition by deformation

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https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Serpin structure, mechanism, and function

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https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Bypassing the kinetic trap of serpin protein folding by loop extension

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https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Mutations in the shutter region of antithrombin result in formation of disulfide-linked dimers and severe venous thrombosis.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

A Kinetic Mechanism for the Polymerization of α1-Antitrypsin

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https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Folding pathway of human alpha 1-antitrypsin: characterization of an intermediate that is active but prone to aggregation

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https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Acid Denaturation of alpha1-antitrypsin: characterization of a novel mechanism of serpin polymerization.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Probing the equilibrium denaturation of the serpin alpha(1)-antitrypsin with single tryptophan mutants; evidence for structure in the urea unfolded state

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

A regulatory hydrophobic area in the flexible joint region of plasminogen activator inhibitor-1, defined with fluorescent activity-neutralizing ligands. Ligand-induced serpin polymerization

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Dimers initiate and propagate serine protease inhibitor polymerisation.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

The Z type variation of human alpha 1-antitrypsin causes a protein folding defect

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Probing the unfolding pathway of alpha1-antitrypsin.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Conformational changes of the reactive-centre loop and beta-strand 5A accompany temperature-dependent inhibitor-substrate transition of plasminogen-activator inhibitor 1

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Retarded protein folding of deficient human alpha 1-antitrypsin D256V and L41P variants

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Deposition diseases and 3D domain swapping

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

3D domain swapping: as domains continue to swap

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

The mechanism of alpha 1-antitrypsin polymerization probed by fluorescence spectroscopy.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

The loss of tryptophan 194 in antichymotrypsin lowers the kinetic barrier to misfolding

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https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Plasminogen activator inhibitor-1 polymers, induced by inactivating amphipathic organochemical ligands

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Nucleation of alpha 1-antichymotrypsin polymerization

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Kinetic characterization of heparin-catalyzed and uncatalyzed inhibition of blood coagulation proteinases by antithrombin.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Robotic nanolitre protein crystallisation at the MRC Laboratory of Molecular Biology.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Likelihood-enhanced fast translation functions

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Coot: model-building tools for molecular graphics

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Structure validation by Calpha geometry: phi,psi and Cbeta deviation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

The serpin inhibitory mechanism is critically dependent on the length of the reactive center loop

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07394

7 January 2021

Identifiers

DOI

10.1038/NATURE07394

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1353359

1015168645

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1353359

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference