Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase (Q27652490)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18849972%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase (English)

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15 January 2020

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20

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15 January 2020

21

Elizabeth D Getzoff

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Elsa D. Garcin

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Elsa D Garcin

1

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author name string

Andrew S Arvai

2

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15 January 2020

Robin J Rosenfeld

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15 January 2020

Matt D Kroeger

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Brian R Crane

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Gunilla Andersson

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15 January 2020

Glen Andrews

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Peter J Hamley

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Philip R Mallinder

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David J Nicholls

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Stephen A St-Gallay

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Alan C Tinker

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Nigel P Gensmantel

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Antonio Mete

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15 January 2020

David R Cheshire

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15 January 2020

Stephen Connolly

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Dennis J Stuehr

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15 January 2020

Anders Aberg

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15 January 2020

Alan V Wallace

19

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15 January 2020

Elizabeth D Getzoff

21

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15 January 2020

publication date

12 October 2008

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15 January 2020

published in

Nature Chemical Biology

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15 January 2020

volume

4

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15 January 2020

issue

11

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15 January 2020

page(s)

700-707

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Minimal Pharmacophoric Elements and Fragment Hopping, an Approach Directed at Molecular Diversity and Isozyme Selectivity. Design of Selective Neuronal Nitric Oxide Synthase Inhibitors

15 January 2020

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20 March 2017

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Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation

20 March 2017

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Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center

20 March 2017

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Structure of nitric oxide synthase oxygenase dimer with pterin and substrate

20 March 2017

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The structure of nitric oxide synthase oxygenase domain and inhibitor complexes

20 March 2017

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A 'specificity' pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

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Improved methods for building protein models in electron density maps and the location of errors in these models

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Characterization of the inducible nitric oxide synthase oxygenase domain identifies a 49 amino acid segment required for subunit dimerization and tetrahydrobiopterin interaction

20 March 2017

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Computational studies of competitive inhibitors of nitric oxide synthase (NOS) enzymes: towards the development of powerful and isoform-selective inhibitors

7 April 2017

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The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitric-oxide synthase

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29 September 2017

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2 June 2018

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27 November 2018

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27 November 2018

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27 November 2018

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27 November 2018

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2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution.

27 November 2018

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Structures of the neuronal and endothelial nitric oxide synthase heme domain with D-nitroarginine-containing dipeptide inhibitors bound

27 November 2018

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Computer modeling of selective regions in the active site of nitric oxide synthases: implication for the design of isoform-selective inhibitors

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PubMed

https://pubmed.ncbi.nlm.nih.gov/18849972

12 December 2020

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Processing of X-ray diffraction data collected in oscillation mode

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PubMed

https://pubmed.ncbi.nlm.nih.gov/18849972

12 December 2020

inferred from PubMed ID database lookup

AMoRe: an automated package for molecular replacement

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Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.115

7 January 2021

inferred from DOI database lookup

Improved Fourier coefficients for maps using phases from partial structures with errors

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7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCHEMBIO.115

1 reference

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Dimensions Publication ID

15 January 2020

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15 January 2020

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