Structure and function of an RNase H domain at the heart of the spliceosome (Q27652459)

4

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Markus C Wahl

object named as

Markus C Wahl

5

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author name string

Vladimir Pena

1

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Alexey Rozov

2

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Patrizia Fabrizio

Crystal structure of the -finger domain of Prp8 reveals analogy to ribosomal proteins

3

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language of work or name

English

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publication date

5 November 2008

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published in

The EMBO Journal

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volume

27

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issue

21

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page(s)

2929-40

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cites work

1 reference

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Crystal Structure of a Self-Spliced Group II Intron

20 March 2017

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20 March 2017

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Crystal structure of the C-terminal domain of splicing factor Prp8 carrying retinitis pigmentosa mutants

20 March 2017

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Structure of a multipartite protein-protein interaction domain in splicing factor prp8 and its link to retinitis pigmentosa

20 March 2017

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Prp8 protein: at the heart of the spliceosome

20 March 2017

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Metal binding and base ionization in the U6 RNA intramolecular stem-loop structure

20 March 2017

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Structure of the 30S ribosomal subunit

20 March 2017

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The complete atomic structure of the large ribosomal subunit at 2.4 A resolution

20 March 2017

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Crystal structure of ribosomal protein L4 shows RNA-binding sites for ribosome incorporation and feedback control of the S10 operon

20 March 2017

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Characterization of U6 snRNA-protein interactions

20 March 2017

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The C-terminal region of hPrp8 interacts with the conserved GU dinucleotide at the 5' splice site

20 March 2017

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Metal ion-mediated substrate-assisted catalysis in type II restriction endonucleases

20 March 2017

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The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein

20 March 2017

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The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro

20 March 2017

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The canonical GU dinucleotide at the 5' splice site is recognized by p220 of the U5 snRNP within the spliceosome

20 March 2017

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A general two-metal-ion mechanism for catalytic RNA

20 March 2017

1 reference

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Prp16p, Slu7p, and Prp8p interact with the 3' splice site in two distinct stages during the second catalytic step of pre-mRNA splicing

20 March 2017

1 reference

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Spatial organization of protein-RNA interactions in the branch site-3' splice site region during pre-mRNA splicing in yeast

20 March 2017

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RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2

20 March 2017

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Mechanical devices of the spliceosome: motors, clocks, springs, and things

20 March 2017

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5-Fluoroorotic acid as a selective agent in yeast molecular genetics

20 March 2017

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The 100-kda U5 snRNP protein (hPrp28p) contacts the 5' splice site through its ATPase site

20 March 2017

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Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis

20 March 2017

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Crystal structure of Argonaute and its implications for RISC slicer activity

7 April 2017

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Allosteric cascade of spliceosome activation

7 April 2017

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The EF-G-like GTPase Snu114p regulates spliceosome dynamics mediated by Brr2p, a DExD/H box ATPase

7 April 2017

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Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release

29 September 2017

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Comparative architecture of transposase and integrase complexes

29 September 2017

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The question remains: is the spliceosome a ribozyme?

29 September 2017

1 reference

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Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation

29 September 2017

1 reference

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Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center

29 September 2017

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Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome.

29 September 2017

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Recognition of the 5' splice site by the spliceosome

29 September 2017

1 reference

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Mutagenesis of the yeast gene PRP8 reveals domains governing the specificity and fidelity of 3' splice site selection

29 September 2017

1 reference

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Direct database searching with MALDI-PSD spectra of peptides

29 September 2017

1 reference

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Dynamic association of proteins with the pre-mRNA branch region

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2580788

Interaction of the yeast splicing factor PRP8 with substrate RNA during both steps of splicing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2580788

Extensive interactions of PRP8 protein with the 5' and 3' splice sites during splicing suggest a role in stabilization of exon alignment by U5 snRNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2580788

Structure and activities of group II introns

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2580788

Dissection of Prp8 protein defines multiple interactions with crucial RNA sequences in the catalytic core of the spliceosome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2580788

Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2580788

An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2580788

Site-specific modification of pre-mRNA: the 2'-hydroxyl groups at the splice sites

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2580788

Roles of PRP8 protein in the assembly of splicing complexes

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2580788

Isolation of an active step I spliceosome and composition of its RNP core.

2 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.209

Suppression of multiple substrate mutations by spliceosomal prp8 alleles suggests functional correlations with ribosomal ambiguity mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.209

Proximity of conserved U6 and U2 snRNA elements to the 5' splice site region in activated spliceosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.209

A novel role for a U5 snRNP protein in 3' splice site selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.209

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.209

Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.209

Metal ion catalysis during splicing of premessenger RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.209

Specific alterations of U1-C protein or U1 small nuclear RNA can eliminate the requirement of Prp28p, an essential DEAD box splicing factor

21 January 2018

1 reference

12 December 2020

alpha- and 3(10)-helix interconversion: a quantum-chemical study on polyalanine systems in the gas phase and in aqueous solvent

1 reference

12 December 2020

Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae

1 reference

12 December 2020

The 5' end of U2 snRNA is in close proximity to U1 and functional sites of the pre-mRNA in early spliceosomal complexes

1 reference

12 December 2020

Splicing factor Prp8 governs U4/U6 RNA unwinding during activation of the spliceosome

1 reference

12 December 2020

release_4hbg3yylqndabeskqn655xhrxy

Identifiers

DOI

10.1038/EMBOJ.2008.209

0 references

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/4hbg3yylqndabeskqn655xhrxy

24 November 2022