Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity (Q27649867)
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| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity |
scientific article |
Statements
Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity (English)
John Newcomb
Joseph J Nunes
Christina Boucher
Lilly Chai
Linda F Epstein
Theodore Faust
Sylvia Flores
Paul Gallant
Anu Gore
Yan Gu
Faye Hsieh
Xin Huang
Joseph L Kim
Scot Middleton
Kurt Morgenstern
Antonio Oliveira-dos-Santos
Vinod F Patel
David Powers
Paul Rose
Yanyan Tudor
Susan M Turci
Andrew A Welcher
Debra Zack
Huilin Zhao
Li Zhu
Xiaotian Zhu
Chiara Ghiron
Monika Ermann
David Johnston
Carl-Gustaf Pierre Saluste