Catalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states (Q27649494)

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English	Catalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states	scientific article

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31 December 2019

Catalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states (English)

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31 December 2019

crystal structure

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31 December 2019

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Ning Shen

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31 December 2019

Minyu Zhou

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31 December 2019

Yadong Yu

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31 December 2019

Xianchi Dong

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31 December 2019

Jianping Ding

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7 January 2008

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31 December 2019

Nucleic Acids Research

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31 December 2019

1288-1299

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31 December 2019

Human tryptophanyl-tRNA synthetase is switched to a tRNA-dependent mode for tryptophan activation by mutations at V85 and I311

1 reference

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20 March 2017

Functional and Crystal Structure Analysis of Active Site Adaptations of a Potent Anti-Angiogenic Human tRNA Synthetase

1 reference

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Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase

1 reference

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20 March 2017

Crystal Structure of Tryptophanyl-tRNA Synthetase Complexed with Adenosine-5′ Tetraphosphate: Evidence for Distributed Use of Catalytic Binding Energy in Amino Acid Activation by Class I Aminoacyl-tRNA Synthetases

1 reference

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20 March 2017

A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase

1 reference

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20 March 2017

Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275098

20 March 2017

Crystal structure of human tryptophanyl-tRNA synthetase catalytic fragment: insights into substrate recognition, tRNA binding, and angiogenesis activity

1 reference

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20 March 2017

Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion

1 reference

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20 March 2017

Interconversion of ATP binding and conformational free energies by tryptophanyl-tRNA synthetase: structures of ATP bound to open and closed, pre-transition-state conformations

1 reference

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20 March 2017

Crystal structure of a human aminoacyl-tRNA synthetase cytokine

1 reference

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20 March 2017

Class I tyrosyl-tRNA synthetase has a class II mode of cognate tRNA recognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275098

20 March 2017

A human aminoacyl-tRNA synthetase as a regulator of angiogenesis

1 reference

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A fragment of human TrpRS as a potent antagonist of ocular angiogenesis

1 reference

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20 March 2017

High-resolution experimental phases for tryptophanyl-tRNA synthetase (TrpRS) complexed with tryptophanyl-5'AMP

1 reference

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20 March 2017

A succession of substrate induced conformational changes ensures the amino acid specificity of Thermus thermophilus prolyl-tRNA synthetase: comparison with histidyl-tRNA synthetase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275098

20 March 2017

How methionyl-tRNA synthetase creates its amino acid recognition pocket upon L-methionine binding

1 reference

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20 March 2017

Structural studies of lysyl-tRNA synthetase: conformational changes induced by substrate binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275098

20 March 2017

Active site of lysyl-tRNA synthetase: structural studies of the adenylation reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275098

20 March 2017

2.9 Å crystal structure of ligand-free tryptophanyl-tRNA synthetase: Domain movements fragment the adenine nucleotide binding site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275098

20 March 2017

Aminoacyl-tRNA synthetases, the genetic code, and the evolutionary process

1 reference

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20 March 2017

Crystal structure of a deletion mutant of a tyrosyl-tRNA synthetase complexed with tyrosine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275098

20 March 2017

Structure of tyrosyl-tRNA synthetase refined at 2.3 A resolution. Interaction of the enzyme with the tyrosyl adenylate intermediate

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20 March 2017

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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20 March 2017

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

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20 March 2017

Tyrosyl-tRNA synthetase acts as an asymmetric dimer in charging tRNA. A rationale for half-of-the-sites activity

1 reference

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20 March 2017

Structure of human tryptophanyl-tRNA synthetase in complex with tRNATrp reveals the molecular basis of tRNA recognition and specificity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275098

29 September 2017

Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275098

29 September 2017

Structural snapshots of the KMSKS loop rearrangement for amino acid activation by bacterial tyrosyl-tRNA synthetase

1 reference

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29 September 2017

CASTp: Computed Atlas of Surface Topography of proteins

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29 September 2017

Species-specific differences in the operational RNA code for aminoacylation of tRNA(Trp)

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29 September 2017

Anatomy of protein pockets and cavities: measurement of binding site geometry and implications for ligand design

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29 September 2017

Reconstruction by site-directed mutagenesis of the transition state for the activation of tyrosine by the tyrosyl-tRNA synthetase: a mobile loop envelopes the transition state in an induced-fit mechanism

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275098

29 September 2017

A conformational transition state accompanies tryptophan activation by B. stearothermophilus tryptophanyl-tRNA synthetase

1 reference

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2 June 2018

Aminoacyl-tRNA synthetases

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275098

2 June 2018

Structural and functional considerations of the aminoacylation reaction

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275098

2 June 2018

Kinetic anticooperativity in pre-steady-state formation of tryptophanyl adenylate by tryptophanyl-tRNA synthetase from beef pancreas. A consequence of the tryptophan anticooperative binding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275098

2 June 2018

Dissection of the structure and activity of the tyrosyl-tRNA synthetase by site-directed mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275098

2 June 2018

Sequence similarities among the family of aminoacyl-tRNA synthetases.

1 reference

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19 June 2018

Tryptophanyl-tRNA synthetase crystal structure reveals an unexpected homology to tyrosyl-tRNA synthetase.

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27 November 2018

Kinetic evidence for half-of-the-sites reactivity in tRNATrp aminoacylation by tryptophanyl-tRNA synthetase from beef pancreas.

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27 November 2018

Tryptophanyl adenylate formation by tryptophanyl-tRNA synthetase from Escherichia coli.

1 reference

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27 November 2018

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://pubmed.ncbi.nlm.nih.gov/18180246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asymmetry of tyrosyl-tRNA synthetase in solution

1 reference

https://pubmed.ncbi.nlm.nih.gov/18180246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the mechanism of tRNATrp aminoacylation catalysed by beef tryptophanyl-tRNA synthetase using presteady-state kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/18180246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An investigation of the mechanism of activation of tryptophan by tryptophanyl-tRNA synthetase from beef pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/18180246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structural basis for seryl-adenylate and Ap4A synthesis by seryl-tRNA synthetase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18180246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative analysis of crystal growth. Tryptophanyl-tRNA synthetase crystal polymorphism and its relationship to catalysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18180246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/NAR/GKM1153

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31 December 2019

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31 December 2019

1 reference

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31 December 2019

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